Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases.

by Igor F Tsigelny, Leslie Crews, Paula Desplats, Gideon M Shaked, Yuriy Sharikov, Hideya Mizuno, Brian Spencer, Edward Rockenstein, Margarita Trejo, Oleksandr Platoshyn, Jason X-J Yuan, Eliezer Masliah
Published 2008-09-01

Synuclein impairs trafficking and signaling of BDNF in a mouse model of Parkinson’s disease

by Fang Fang, Wanlin Yang, Jazmin B. Florio, Edward Rockenstein, Brian Spencer, Xavier M. Orain, Stephanie X. Dong, Huayan Li, Xuqiao Chen, Kijung Sung, Robert A. Rissman, Eliezer Masliah, Jianqing Ding, Chengbiao Wu
Published 2017-06-01

TOM40 mediates mitochondrial dysfunction induced by α-synuclein accumulation in Parkinson's disease.

by Andreas Bender, Paula Desplats, Brian Spencer, Edward Rockenstein, Anthony Adame, Matthias Elstner, Christoph Laub, Sarina Mueller, Andrew O Koob, Michael Mante, Emily Pham, Thomas Klopstock, Eliezer Masliah
Published 2013-01-01

Tau reduction does not prevent motor deficits in two mouse models of Parkinson's disease.

by Meaghan Morris, Akihiko Koyama, Eliezer Masliah, Lennart Mucke
Published 2011-01-01

Non-toxic HSC Transplantation-Based Macrophage/Microglia-Mediated GDNF Delivery for Parkinson’s Disease

by Cang Chen, Michael J. Guderyon, Yang Li, Guo Ge, Anindita Bhattacharjee, Cori Ballard, Zhixu He, Eliezer Masliah, Robert A. Clark, Jason C. O’Connor, Senlin Li
Published 2020-06-01

Motor and Nonmotor Symptoms of Parkinson’s Disease: Antagonistic Pleiotropy Phenomena Derived from α-Synuclein Evolvability?

by Yoshiki Takamatsu, Masayo Fujita, Gilbert J. Ho, Ryoko Wada, Shuei Sugama, Takato Takenouchi, Masaaki Waragai, Eliezer Masliah, Makoto Hashimoto
Published 2018-01-01

Neuropeptide Treatment with Cerebrolysin Enhances the Survival of Grafted Neural Stem Cell in an α-Synuclein Transgenic Model of Parkinson’s Disease

by Edward Rockenstein, Paula Desplats, Kiren Ubhi, Michael Mante, Jazmin Florio, Anthony Adame, Stefan Winter, Hemma Brandstaetter, Dieter Meier, Herbert Moessler, Eliezer Masliah
Published 2016-07-01

Neuropeptide Treatment with Cerebrolysin Enhances the Survival of Grafted Neural Stem Cell in an α-Synuclein Transgenic Model of Parkinson's Disease

by Edward Rockenstein, Paula Desplats, Kiren Ubhi, Michael Mante, Jazmin Florio, Anthony Adame, Stefan Winter, Hemma Brandstaetter, Dieter Meier, Herbert Moessler, Eliezer Masliah
Published 2015-01-01

The small molecule alpha-synuclein misfolding inhibitor, NPT200-11, produces multiple benefits in an animal model of Parkinson’s disease

by Diana L. Price, Maya A. Koike, Asma Khan, Wolfgang Wrasidlo, Edward Rockenstein, Eliezer Masliah, Douglas Bonhaus
Published 2018-11-01

Severely impaired hippocampal neurogenesis associates with an early serotonergic deficit in a BAC α-synuclein transgenic rat model of Parkinson's disease

by Zacharias Kohl, Nada Ben Abdallah, Jonathan Vogelgsang, Lucas Tischer, Janina Deusser, Davide Amato, Scott Anderson, Christian P. Müller, Olaf Riess, Eliezer Masliah, Silke Nuber, Jürgen Winkler
Published 2016-01-01

Assessment of APOE in atypical parkinsonism syndromes

by Marya S. Sabir, Cornelis Blauwendraat, Sarah Ahmed, Geidy E. Serrano, Thomas G. Beach, Matthew Perkins, Ann C. Rice, Eliezer Masliah, Christopher M. Morris, Lasse Pihlstrom, Alexander Pantelyat, Susan M. Resnick, Mark R. Cookson, Dena G. Hernandez, Marilyn Albert, Ted M. Dawson, Liana S. Rosenthal, Henry Houlden, Olga Pletnikova, Juan Troncoso, Sonja W. Scholz
Published 2019-07-01

Alpha-synuclein pathology, microgliosis, and parvalbumin neuron loss in the amygdala associated with enhanced fear in the Thy1-aSyn model of Parkinson's disease

by Eileen Ruth S. Torres, Milos Stanojlovic, Moriel Zelikowsky, Jana Bonsberger, Sindalana Hean, Caitlin Mulligan, Leonie Baldauf, Sheila Fleming, Eliezer Masliah, Marie-Francoise Chesselet, Michael S. Fanselow, Franziska Richter
Published 2021-10-01

Therapeutic Potential of αS Evolvability for NeuropathicGaucher Disease

by Jianshe Wei, Yoshiki Takamatsu, Ryoko Wada, Masayo Fujita, Gilbert Ho, Eliezer Masliah, Makoto Hashimoto
Published 2021-02-01

Neuroinflammation is associated with infiltration of T cells in Lewy body disease and α-synuclein transgenic models

by Michiyo Iba, Changyoun Kim, Michelle Sallin, Somin Kwon, Anjali Verma, Cassia Overk, Robert A. Rissman, Ranjan Sen, Jyoti Misra Sen, Eliezer Masliah
Published 2020-07-01

Differential effects of immunotherapy with antibodies targeting α-synuclein oligomers and fibrils in a transgenic model of synucleinopathy

by Omar El-Agnaf, Cassia Overk, Edward Rockenstein, Michael Mante, Jazmin Florio, Anthony Adame, Nishant Vaikath, Nour Majbour, Seung-Jae Lee, Changyoun Kim, Eliezer Masliah, Robert A. Rissman
Published 2017-08-01

Glial A30P alpha-synuclein pathology segregates neurogenesis from anxiety-related behavior in conditional transgenic mice

by Franz Marxreiter, Benjamin Ettle, Verena E.L. May, Hakan Esmer, Christina Patrick, Christine Lund Kragh, Jochen Klucken, Beate Winner, Olaf Riess, Jürgen Winkler, Eliezer Masliah, Silke Nuber
Published 2013-11-01

Systemic peptide mediated delivery of an siRNA targeting α-syn in the CNS ameliorates the neurodegenerative process in a transgenic model of Lewy body disease

by Brian Spencer, Ivy Trinh, Edward Rockenstein, Michael Mante, Jazmin Florio, Anthony Adame, Omar M.A. El-Agnaf, Changyoun Kim, Eliezer Masliah, Robert A. Rissman
Published 2019-07-01

Preclinical development of a high affinity α-synuclein antibody, MEDI1341, that can enter the brain, sequester extracellular α-synuclein and attenuate α-synuclein spreading in vivo...

by Darren J. Schofield, Lorraine Irving, Laura Calo, Anna Bogstedt, Gareth Rees, Annalisa Nuccitelli, Rajesh Narwal, Marcella Petrone, Jennifer Roberts, Lee Brown, Fiona Cusdin, Bhupinder Dosanjh, Christopher Lloyd, Claire Dobson, Ian Gurrell, Graham Fraser, Mary McFarlane, Edward Rockenstein, Brian Spencer, Eliezer Masliah, Maria Grazia Spillantini, Keith Tan, Andrew Billinton, Tris Vaughan, Iain Chessell, Michael S. Perkinton
Published 2019-12-01

Adiponectin Paradox in Alzheimer's Disease; Relevance to Amyloidogenic Evolvability?

by Masaaki Waragai, Gilbert Ho, Yoshiki Takamatsu, Ryoko Wada, Shuei Sugama, Takato Takenouchi, Eliezer Masliah, Makoto Hashimoto
Published 2020-03-01

Analysis of neurodegenerative disease-causing genes in dementia with Lewy bodies

by Tatiana Orme, Dena Hernandez, Owen A. Ross, Celia Kun-Rodrigues, Lee Darwent, Claire E. Shepherd, Laura Parkkinen, Olaf Ansorge, Lorraine Clark, Lawrence S. Honig, Karen Marder, Afina Lemstra, Ekaterina Rogaeva, Peter St. George-Hyslop, Elisabet Londos, Henrik Zetterberg, Kevin Morgan, Claire Troakes, Safa Al-Sarraj, Tammaryn Lashley, Janice Holton, Yaroslau Compta, Vivianna Van Deerlin, John Q. Trojanowski, Geidy E. Serrano, Thomas G. Beach, Suzanne Lesage, Douglas Galasko, Eliezer Masliah, Isabel Santana, Pau Pastor, Pentti J. Tienari, Liisa Myllykangas, Minna Oinas, Tamas Revesz, Andrew Lees, Brad F. Boeve, Ronald C. Petersen, Tanis J. Ferman, Valentina Escott-Price, Neill Graff-Radford, Nigel J. Cairns, John C. Morris, Stuart Pickering-Brown, David Mann, Glenda Halliday, David J. Stone, Dennis W. Dickson, John Hardy, Andrew Singleton, Rita Guerreiro, Jose Bras
Published 2020-01-01