The IL‐6 signaling complex is a critical driver, negative prognostic factor, and therapeutic target in diffuse large B‐cell lymphoma

by Hind Hashwah, Katrin Bertram, Kristin Stirm, Anna Stelling, Cheuk‐Ting Wu, Sabrina Kasser, Markus G Manz, Alexandre P Theocharides, Alexandar Tzankov, Anne Müller
Published 2019-10-01

Characterisation of cardiac pathology in 23 autopsies of lethal COVID‐19

by Jasmin D Haslbauer, Alexandar Tzankov, Kirsten D Mertz, Nathalie Schwab, Ronny Nienhold, Raphael Twerenbold, Gregor Leibundgut, Anna K Stalder, Matthias Matter, Katharina Glatz
Published 2021-07-01

Outpatient and inpatient anticoagulation therapy and the risk for hospital admission and death among COVID-19 patients

by Sameh M. Hozayen, Diana Zychowski, Sydney Benson, Pamela L. Lutsey, Jasmin Haslbauer, Alexandar Tzankov, Zachary Kaltenborn, Michael Usher, Surbhi Shah, Christopher J. Tignanelli, Ryan T. Demmer
Published 2021-11-01

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and coronavirus disease 19 (COVID-19) – anatomic pathology perspective on current knowledge

by Sambit K. Mohanty, Abhishek Satapathy, Machita M. Naidu, Sanjay Mukhopadhyay, Shivani Sharma, Lisa M. Barton, Edana Stroberg, Eric J. Duval, Dinesh Pradhan, Alexandar Tzankov, Anil V. Parwani
Published 2020-08-01

The Role of Innate Immunity and Bioactive Lipid Mediators in COVID-19 and Influenza

by Sabina Sahanic, Judith Löffler-Ragg, Piotr Tymoszuk, Richard Hilbe, Egon Demetz, Rebecca K Masanetz, Markus Theurl, Johannes Holfeld, Can Gollmann-Tepeköylü, Alexandar Tzankov, Guenter Weiss, Martin Giera, Ivan Tancevski
Published 2021-07-01

Nuclear receptor NR2F6 inhibition potentiates responses to PD-L1/PD-1 cancer immune checkpoint blockade

by Victoria Klepsch, Natascha Hermann-Kleiter, Patricia Do-Dinh, Bojana Jakic, Anne Offermann, Mirjana Efremova, Sieghart Sopper, Dietmar Rieder, Anne Krogsdam, Gabriele Gamerith, Sven Perner, Alexandar Tzankov, Zlatko Trajanoski, Dominik Wolf, Gottfried Baier
Published 2018-04-01

A Novel Inducible Mouse Model of MLL-ENL-driven Mixed-lineage Acute Leukemia

by Vaia Stavropoulou, Marwa Almosailleakh, Hélène Royo, Jean-François Spetz, Sabine Juge, Laurent Brault, Patrick Kopp, Michelina Iacovino, Michael Kyba, Alexandar Tzankov, Michael B. Stadler, Gianni Cazzaniga, Antoine H.F.M. Peters, Juerg Schwaller
Published 2018-08-01

Nuclear interacting SET domain protein 1 inactivation impairs GATA1-regulated erythroid differentiation and causes erythroleukemia

by Katharina Leonards, Marwa Almosailleakh, Samantha Tauchmann, Frederik Otzen Bagger, Cécile Thirant, Sabine Juge, Thomas Bock, Hélène Méreau, Matheus F. Bezerra, Alexandar Tzankov, Robert Ivanek, Régine Losson, Antoine H. F. M. Peters, Thomas Mercher, Juerg Schwaller
Published 2020-06-01

Two distinct immunopathological profiles in autopsy lungs of COVID-19

by Ronny Nienhold, Yari Ciani, Viktor H. Koelzer, Alexandar Tzankov, Jasmin D. Haslbauer, Thomas Menter, Nathalie Schwab, Maurice Henkel, Angela Frank, Veronika Zsikla, Niels Willi, Werner Kempf, Thomas Hoyler, Mattia Barbareschi, Holger Moch, Markus Tolnay, Gieri Cathomas, Francesca Demichelis, Tobias Junt, Kirsten D. Mertz
Published 2020-10-01

XPO1 expression worsens the prognosis of unfavorable DLBCL that can be effectively targeted by selinexor in the absence of mutant p53

by Manman Deng, Mingzhi Zhang, Zijun Y. Xu-Monette, Lan V. Pham, Alexandar Tzankov, Carlo Visco, Xiaosheng Fang, Govind Bhagat, Feng Zhu, Karen Dybkaer, April Chiu, Wayne Tam, Youli Zu, Eric D. Hsi, William W. L. Choi, Jooryung Huh, Maurilio Ponzoni, Andrés J. M. Ferreri, Michael B. Møller, Benjamin M. Parsons, J. Han van Krieken, Miguel A. Piris, Jane N. Winter, Fredrick Hagemeister, Lapo Alinari, Yong Li, Michael Andreeff, Bing Xu, Ken H. Young
Published 2020-11-01

Immunoglobulin somatic hypermutation has clinical impact in DLBCL and potential implications for immune checkpoint blockade and neoantigen-based immunotherapies

by Zijun Y. Xu-Monette, Jianyong Li, Yi Xia, Beryl Crossley, Robert D. Bremel, Yi Miao, Min Xiao, Thomas Snyder, Ganiraju C. Manyam, Xiaohong Tan, Hongwei Zhang, Carlo Visco, Alexandar Tzankov, Karen Dybkaer, Govind Bhagat, Wayne Tam, Hua You, Eric D. Hsi, J. Han van Krieken, Jooryung Huh, Maurilio Ponzoni, Andrés J. M. Ferreri, Michael B. Møller, Miguel A. Piris, Jane N. Winter, Jeffrey T. Medeiros, Bing Xu, Yong Li, Ilan Kirsch, Ken H. Young
Published 2019-10-01

Genomic complexity is associated with epigenetic regulator mutations and poor prognosis in diffuse large B-cell lymphoma

by Hua You, Zijun Y. Xu-Monette, Li Wei, Harry Nunns, Máté L. Nagy, Govind Bhagat, Xiaosheng Fang, Feng Zhu, Carlo Visco, Alexandar Tzankov, Karen Dybkaer, April Chiu, Wayne Tam, Youli Zu, Eric D. Hsi, Fredrick B. Hagemeister, Jooryung Huh, Maurilio Ponzoni, Andrés J.M. Ferreri, Michael B. Møller, Benjamin M. Parsons, J. Han Van Krieken, Miguel A. Piris, Jane N. Winter, Yong Li, Qingyan Au, Bing Xu, Maher Albitar, Ken H. Young
Published 2021-01-01

Clinical Significance of PTEN Deletion, Mutation, and Loss of PTEN Expression in De Novo Diffuse Large B-Cell Lymphoma

by Xiaoxiao Wang, Xin Cao, Ruifang Sun, Charlene Tang, Alexandar Tzankov, Jun Zhang, Ganiraju C. Manyam, Min Xiao, Yi Miao, Kausar Jabbar, Xiaohong Tan, Yuyang Pang, Carlo Visco, Yan Xie, Karen Dybkaer, April Chiu, Attilio Orazi, Youli Zu, Govind Bhagat, Kristy L. Richards, Eric D. Hsi, William W.L. Choi, J. Han van Krieken, Jooryung Huh, Maurilio Ponzoni, Andrés J.M. Ferreri, Michael B. Møller, Ben M. Parsons, Jane N. Winter, Miguel A. Piris, Shaoying Li, Roberto N. Miranda, L. Jeffrey Medeiros, Yong Li, Zijun Y. Xu-Monette, Ken H. Young
Published 2018-06-01

ACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBs

by Ivan T. Lee, Tsuguhisa Nakayama, Chien-Ting Wu, Yury Goltsev, Sizun Jiang, Phillip A. Gall, Chun-Kang Liao, Liang-Chun Shih, Christian M. Schürch, David R. McIlwain, Pauline Chu, Nicole A. Borchard, David Zarabanda, Sachi S. Dholakia, Angela Yang, Dayoung Kim, Han Chen, Tomoharu Kanie, Chia-Der Lin, Ming-Hsui Tsai, Katie M. Phillips, Raymond Kim, Jonathan B. Overdevest, Matthew A. Tyler, Carol H. Yan, Chih-Feng Lin, Yi-Tsen Lin, Da-Tian Bau, Gregory J. Tsay, Zara M. Patel, Yung-An Tsou, Alexandar Tzankov, Matthias S. Matter, Chih-Jaan Tai, Te-Huei Yeh, Peter H. Hwang, Garry P. Nolan, Jayakar V. Nayak, Peter K. Jackson
Published 2020-10-01

Molecular and functional profiling identifies therapeutically targetable vulnerabilities in plasmablastic lymphoma

by Fabian Frontzek, Annette M. Staiger, Myroslav Zapukhlyak, Wendan Xu, Irina Bonzheim, Vanessa Borgmann, Philip Sander, Maria Joao Baptista, Jan-Niklas Heming, Philipp Berning, Ramona Wullenkord, Tabea Erdmann, Mathias Lutz, Pia Veratti, Sophia Ehrenfeld, Kirsty Wienand, Heike Horn, John R. Goodlad, Matthew R. Wilson, Ioannis Anagnostopoulos, Mario Lamping, Eva Gonzalez-Barca, Fina Climent, Antonio Salar, Josep Castellvi, Pau Abrisqueta, Javier Menarguez, Teresa Aldamiz, Julia Richter, Wolfram Klapper, Alexandar Tzankov, Stefan Dirnhofer, Andreas Rosenwald, José Luis Mate, Gustavo Tapia, Peter Lenz, Cornelius Miething, Wolfgang Hartmann, Björn Chapuy, Falko Fend, German Ott, José-Tomas Navarro, Michael Grau, Georg Lenz
Published 2021-08-01