Decreased microbiome diversity in the HIV small airway epithelium

by Stella Xu, Amy Tsai, Marc A. Sze, Emily A. Vucic, Tawimas Shaipanich, Marianne Harris, Silvia Guillemi, Julia Yang, Sunita Sinha, Corey Nislow, Julio Montaner, Wan Lam, Stephen Lam, Don D. Sin, S. F. Paul Man, Janice M. Leung
Published 2018-07-01

Bronchodilator responsiveness and reported respiratory symptoms in an adult population.

by Wan C Tan, Jean Bourbeau, Paul Hernandez, Kenneth R Chapman, Robert Cowie, J Mark FitzGerald, Shawn Aaron, Darcy D Marciniuk, Francois Maltais, A Sonia Buist, Denis E O'Donnell, Don D Sin, CanCOLD Collaborative Research Group
Published 2013-01-01

Responsiveness to Ipratropium Bromide in Male and Female Patients with Mild to Moderate Chronic Obstructive Pulmonary Disease

by Xuan Li, Ma'en Obeidat, Guohai Zhou, Janice M. Leung, Donald Tashkin, Robert Wise, John Connett, Philippe Joubert, Yohan Bossé, Maarten van den Berge, Corry-Anke Brandsma, David C. Nickle, Ke Hao, Peter D. Paré, Don D. Sin
Published 2017-05-01

Network-based analysis reveals novel gene signatures in peripheral blood of patients with chronic obstructive pulmonary disease

by Ma’en Obeidat, Yunlong Nie, Virginia Chen, Casey P. Shannon, Anand Kumar Andiappan, Bernett Lee, Olaf Rotzschke, Peter J. Castaldi, Craig P. Hersh, Nick Fishbane, Raymond T. Ng, Bruce McManus, Bruce E. Miller, Stephen Rennard, Peter D. Paré, Don D. Sin
Published 2017-04-01

Dyspnoea and symptom burden in mild–moderate COPD: the Canadian Cohort Obstructive Lung Disease Study

by Mathew Cherian, Dennis Jensen, Wan C. Tan, Sara Mursleen, Emma C. Goodall, Gilbert A. Nadeau, Amnah M. Awan, Darcy D. Marciniuk, Brandie L. Walker, Shawn D. Aaron, Denis E. O'Donnell, Kenneth R. Chapman, François Maltais, Paul Hernandez, Don D. Sin, Andrea Benedetti, Jean Bourbeau
Published 2021-04-01

IL-4Rα blockade reduces influenza-associated morbidity in a murine model of allergic asthma

by Kimia Shahangian, David A. Ngan, H. H. Rachel Chen, Yeni Oh, Anthony Tam, Jing Wen, Chung Cheung, Darryl A. Knight, Delbert R. Dorscheid, Tillie L. Hackett, Michael R. Hughes, Kelly M. McNagny, Jeremy A. Hirota, Masahiro Niikura, S. F. Paul Man, Don D. Sin
Published 2021-03-01

Radiofrequency therapy improves exercise capacity of mice with emphysema

by Mai Tsutsui, Chung Yan Cheung, Takeyuki Wada, Jen-erh Jaw, Cheng Wei Tony Yang, Pascal Bernatchez, Zoe White, Chen Xi Yang, Eun Jeong Annie Bae, Lauren H. Choi, Dan Gelbart, Samuel Lichtenstein, Lindsay Machan, Eran Elizur, Kim Wolff, Evan Goodacre, Marek Lipnicki, Denny Wong, Don D. Sin
Published 2021-10-01

COPD Exacerbation Biomarkers Validated Using Multiple Reaction Monitoring Mass Spectrometry.

by Janice M Leung, Virginia Chen, Zsuzsanna Hollander, Darlene Dai, Scott J Tebbutt, Shawn D Aaron, Kathy L Vandemheen, Stephen I Rennard, J Mark FitzGerald, Prescott G Woodruff, Stephen C Lazarus, John E Connett, Harvey O Coxson, Bruce Miller, Christoph Borchers, Bruce M McManus, Raymond T Ng, Don D Sin
Published 2016-01-01

Serum IgG subclass levels and risk of exacerbations and hospitalizations in patients with COPD

by Fernando Sergio Leitao Filho, Seung Won Ra, Andre Mattman, Robert S. Schellenberg, Gerard J. Criner, Prescott G. Woodruff, Stephen C. Lazarus, Richard Albert, John E. Connett, Meilan K. Han, Fernando J. Martinez, Janice M. Leung, S. F. Paul Man, Shawn D. Aaron, Robert M. Reed, Don D. Sin, for the Canadian Respiratory Research Network (CRRN)
Published 2018-02-01

Absolute leukocyte telomere length in HIV-infected and uninfected individuals: evidence of accelerated cell senescence in HIV-associated chronic obstructive pulmonary disease.

by Joseph C Y Liu, Janice M Leung, David A Ngan, Negar F Nashta, Silvia Guillemi, Marianne Harris, Viviane D Lima, Soo-Jung Um, Yuexin Li, Sheena Tam, Tawimas Shaipanich, Rekha Raju, Cameron Hague, Jonathon A Leipsic, Jean Bourbeau, Wan C Tan, P Richard Harrigan, Don D Sin, Julio Montaner, S F Paul Man
Published 2015-01-01

Azithromycin and risk of COPD exacerbations in patients with and without Helicobacter pylori

by Seung Won Ra, Marc A. Sze, Eun Chong Lee, Sheena Tam, Yeni Oh, Nick Fishbane, Gerard J. Criner, Prescott G. Woodruff, Stephen C. Lazarus, Richard Albert, John E. Connett, Meilan K. Han, Fernando J. Martinez, Shawn D. Aaron, Robert M. Reed, S. F. Paul Man, Don D. Sin, on behalf of the Canadian Respiratory Research Network
Published 2017-05-01

Macrophages with reduced expressions of classical M1 and M2 surface markers in human bronchoalveolar lavage fluid exhibit pro-inflammatory gene signatures

by Hiroto Takiguchi, Chen X. Yang, Cheng Wei Tony Yang, Basak Sahin, Beth A. Whalen, Stephen Milne, Kentaro Akata, Kei Yamasaki, Julia Shun Wei Yang, Chung Yan Cheung, Ryan Vander Werff, Kelly M. McNagny, Fernando Sergio Leitao Filho, Tawimas Shaipanich, Stephan F. van Eeden, Ma’en Obeidat, Janice M. Leung, Don D. Sin
Published 2021-04-01

Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank

by Kim Valette, Zhonglin Li, Valentin Bon-Baret, Arnaud Chignon, Jean-Christophe Bérubé, Aida Eslami, Jennifer Lamothe, Nathalie Gaudreault, Philippe Joubert, Ma’en Obeidat, Maarten van den Berge, Wim Timens, Don D. Sin, David C. Nickle, Ke Hao, Catherine Labbé, Krystelle Godbout, Andréanne Côté, Michel Laviolette, Louis-Philippe Boulet, Patrick Mathieu, Sébastien Thériault, Yohan Bossé
Published 2021-06-01

Whole exome re-sequencing implicates CCDC38 and cilia structure and function in resistance to smoking related airflow obstruction.

by Louise V Wain, Ian Sayers, María Soler Artigas, Michael A Portelli, Eleftheria Zeggini, Ma'en Obeidat, Don D Sin, Yohan Bossé, David Nickle, Corry-Anke Brandsma, Anders Malarstig, Ciara Vangjeli, Scott A Jelinsky, Sally John, Iain Kilty, Tricia McKeever, Nick R G Shrine, James P Cook, Shrina Patel, Tim D Spector, Edward J Hollox, Ian P Hall, Martin D Tobin
Published 2014-05-01

Findings on Thoracic Computed Tomography Scans and Respiratory Outcomes in Persons with and without Chronic Obstructive Pulmonary Disease: A Population-Based Cohort Study.

by Wan C Tan, Cameron J Hague, Jonathon Leipsic, Jean Bourbeau, Liyun Zheng, Pei Z Li, Don D Sin, Harvey O Coxson, Miranda Kirby, James C Hogg, Rekha Raju, Jeremy Road, Denis E O'Donnell, Francois Maltais, Paul Hernandez, Robert Cowie, Kenneth R Chapman, Darcy D Marciniuk, J Mark FitzGerald, Shawn D Aaron, Canadian Respiratory Research Network and the CanCOLD Collaborative Research group
Published 2016-01-01

Correction: Lung eQTLs to Help Reveal the Molecular Underpinnings of Asthma

by Ke Hao, Yohan Bossé, David C. Nickle, Peter D. Paré, Dirkje S. Postma, Michel Laviolette, Andrew Sandford, Tillie L. Hackett, Denise Daley, James C. Hogg, W. Mark Elliott, Christian Couture, Maxime Lamontagne, Corry-Anke Brandsma, Maarten van den Berge, Gerard Koppelman, Alise S. Reicin, Donald W. Nicholson, Vladislav Malkov, Jonathan M. Derry, Christine Suver, Jeffrey A. Tsou, Amit Kulkarni, Chunsheng Zhang, Rupert Vessey, Greg J. Opiteck, Sean P. Curtis, Wim Timens, Don D. Sin
Published 2012-12-01

Correction: Lung eQTLs to Help Reveal the Molecular Underpinnings of Asthma.

by Ke Hao, Yohan Bossé, David C. Nickle, Peter D. Paré, Dirkje S. Postma, Michel Laviolette, Andrew Sandford, Tillie L. Hackett, Denise Daley, James C. Hogg, W. Mark Elliott, Christian Couture, Maxime Lamontagne, Corry-Anke Brandsma, Maarten van den Berge, Gerard Koppelman, Alise S. Reicin, Donald W. Nicholson, Vladislav Malkov, Jonathan M. Derry, Christine Suver, Jeffrey A. Tsou, Amit Kulkarni, Chunsheng Zhang, Rupert Vessey, Greg J. Opiteck, Sean P. Curtis, Wim Timens, Don D. Sin
Published 2012-12-01

Lung eQTLs to help reveal the molecular underpinnings of asthma.

by Ke Hao, Yohan Bossé, David C Nickle, Peter D Paré, Dirkje S Postma, Michel Laviolette, Andrew Sandford, Tillie L Hackett, Denise Daley, James C Hogg, W Mark Elliott, Christian Couture, Maxime Lamontagne, Corry-Anke Brandsma, Maarten van den Berge, Gerard Koppelman, Alise S Reicin, Donald W Nicholson, Vladislav Malkov, Jonathan M Derry, Christine Suver, Jeffrey A Tsou, Amit Kulkarni, Chunsheng Zhang, Rupert Vessey, Greg J Opiteck, Sean P Curtis, Wim Timens, Don D Sin
Published 2012-01-01

ACE inhibition and cardiometabolic risk factors, lung ACE2 and TMPRSS2 gene expression, and plasma ACE2 levels: a Mendelian randomization study

by Dipender Gill, Marios Arvanitis, Paul Carter, Ana I. Hernández Cordero, Brian Jo, Ville Karhunen, Susanna C. Larsson, Xuan Li, Sam M. Lockhart, Amy Mason, Evanthia Pashos, Ashis Saha, Vanessa Y. Tan, Verena Zuber, Yohan Bossé, Sarah Fahle, Ke Hao, Tao Jiang, Philippe Joubert, Alan C. Lunt, Willem Hendrik Ouwehand, David J. Roberts, Wim Timens, Maarten van den Berge, Nicholas A. Watkins, Alexis Battle, Adam S. Butterworth, John Danesh, Emanuele Di Angelantonio, Barbara E. Engelhardt, James E. Peters, Don D. Sin, Stephen Burgess
Published 2020-11-01

Large-scale external validation and comparison of prognostic models: an application to chronic obstructive pulmonary disease

by Beniamino Guerra, Sarah R. Haile, Bernd Lamprecht, Ana S. Ramírez, Pablo Martinez-Camblor, Bernhard Kaiser, Inmaculada Alfageme, Pere Almagro, Ciro Casanova, Cristóbal Esteban-González, Juan J. Soler-Cataluña, Juan P. de-Torres, Marc Miravitlles, Bartolome R. Celli, Jose M. Marin, Gerben ter Riet, Patricia Sobradillo, Peter Lange, Judith Garcia-Aymerich, Josep M. Antó, Alice M. Turner, Meilan K. Han, Arnulf Langhammer, Linda Leivseth, Per Bakke, Ane Johannessen, Toru Oga, Borja Cosio, Julio Ancochea-Bermúdez, Andres Echazarreta, Nicolas Roche, Pierre-Régis Burgel, Don D. Sin, Joan B. Soriano, Milo A. Puhan, for the 3CIA collaboration
Published 2018-03-01