The Early Activation of CD8+ T Cells Is Dependent on Type I IFN Signaling following Intramuscular Vaccination of Adenovirus Vector

by Masahisa Hemmi, Masashi Tachibana, Sayaka Tsuzuki, Masaki Shoji, Fuminori Sakurai, Kenji Kawabata, Kouji Kobiyama, Ken J. Ishii, Shizuo Akira, Hiroyuki Mizuguchi
Published 2014-01-01

Type I interferon signaling regulates Ly6C(hi) monocytes and neutrophils during acute viral pneumonia in mice.

by Sang-Uk Seo, Hyung-Joon Kwon, Hyun-Jeong Ko, Young-Ho Byun, Baik Lin Seong, Satoshi Uematsu, Shizuo Akira, Mi-Na Kweon
Published 2011-02-01

Systemic Toll-like receptor stimulation suppresses experimental allergic asthma and autoimmune diabetes in NOD mice.

by Aude Aumeunier, Françoise Grela, Abdulraouf Ramadan, Linh Pham Van, Emilie Bardel, Alejandro Gomez Alcala, Pascale Jeannin, Shizuo Akira, Jean-François Bach, Nathalie Thieblemont
Published 2010-01-01

DNA-Encoded Flagellin Activates Toll-Like Receptor 5 (TLR5), Nod-like Receptor Family CARD Domain-Containing Protein 4 (NRLC4), and Acts as an Epidermal, Systemic, and Mucosal-Adju...

by Steven E. Applequist, Shizuo Akira, Jorma Hinkula, Daniel X. Johansson, Ulf Schröder, Satoshi Uematsu, Björn Rissiek, Claudia Devito, Andreas Bråve, Tina Falkeborn, Sanna Nyström
Published 2013-09-01

NFATc1 mediates Toll-like receptor-independent innate immune responses during Trypanosoma cruzi infection.

by Hisako Kayama, Ritsuko Koga, Koji Atarashi, Megumi Okuyama, Taishi Kimura, Tak W Mak, Satoshi Uematsu, Shizuo Akira, Hiroshi Takayanagi, Kenya Honda, Masahiro Yamamoto, Kiyoshi Takeda
Published 2009-07-01

The chemotherapeutic agent DMXAA as a unique IRF3-dependent type-2 vaccine adjuvant.

by Choon Kit Tang, Taiki Aoshi, Nao Jounai, Junichi Ito, Keiichi Ohata, Kouji Kobiyama, Benoit H Dessailly, Etsushi Kuroda, Shizuo Akira, Kenji Mizuguchi, Cevayir Coban, Ken J Ishii
Published 2013-01-01

Microsomal prostaglandin E synthase-1 promotes lung metastasis via SDF-1/CXCR4-mediated recruitment of CD11b+Gr1+MDSCs from bone marrow

by Ryo Takahashi, Hideki Amano, Yoshiya Ito, Koji Eshima, Takefumi Satoh, Masatsugu Iwamura, Masaki Nakamura, Hidero Kitasato, Satoshi Uematsu, Joan Raouf, Per-Johan Jakobsson, Shizuo Akira, Masataka Majima
Published 2020-01-01

Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis

by Hiroyasu Kidoya, Fumitaka Muramatsu, Teppei Shimamura, Weizhen Jia, Takashi Satoh, Yumiko Hayashi, Hisamichi Naito, Yuya Kunisaki, Fumio Arai, Masahide Seki, Yutaka Suzuki, Tsuyoshi Osawa, Shizuo Akira, Nobuyuki Takakura
Published 2019-03-01

Rapid host defense against Aspergillus fumigatus involves alveolar macrophages with a predominance of alternatively activated phenotype.

by Shikha Bhatia, Mingjian Fei, Manohar Yarlagadda, Zengbiao Qi, Shizuo Akira, Shinobu Saijo, Yoichiro Iwakura, Nico van Rooijen, Gregory A Gibson, Claudette M St Croix, Anuradha Ray, Prabir Ray
Published 2011-01-01

In situ microscopy analysis reveals local innate immune response developed around Brucella infected cells in resistant and susceptible mice.

by Richard Copin, Marie-Alice Vitry, Delphine Hanot Mambres, Arnaud Machelart, Carl De Trez, Jean-Marie Vanderwinden, Stefan Magez, Shizuo Akira, Bernhard Ryffel, Yves Carlier, Jean-Jacques Letesson, Eric Muraille
Published 2012-01-01

Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis

by Jiefei Geng, Yasushi Ito, Linyu Shi, Palak Amin, Jiachen Chu, Amanda Tomie Ouchida, Adnan Kasim Mookhtiar, Heng Zhao, Daichao Xu, Bing Shan, Ayaz Najafov, Guangping Gao, Shizuo Akira, Junying Yuan
Published 2017-08-01

TRAF6 is required for generation of the B-1a B cell compartment as well as T cell-dependent and -independent humoral immune responses.

by Takashi Kobayashi, Tae Soo Kim, Anand Jacob, Matthew C Walsh, Yuho Kadono, Ezequiel Fuentes-Pananá, Tomoko Yoshioka, Akihiko Yoshimura, Masahiro Yamamoto, Tsuneyasu Kaisho, Shizuo Akira, John G Monroe, Yongwon Choi
Published 2009-01-01

Loss of IL-33 enhances elastase-induced and cigarette smoke extract-induced emphysema in mice

by Daisuke Morichika, Akihiko Taniguchi, Naohiro Oda, Utako Fujii, Satoru Senoo, Junko Itano, Arihiko Kanehiro, Yoshiaki Kitaguchi, Masanori Yasuo, Masayuki Hanaoka, Takashi Satoh, Shizuo Akira, Katsuyuki Kiura, Yoshinobu Maeda, Nobuaki Miyahara
Published 2021-05-01

Innate immune sensing of modified vaccinia virus Ankara (MVA) is mediated by TLR2-TLR6, MDA-5 and the NALP3 inflammasome.

by Julie Delaloye, Thierry Roger, Quynh-Giao Steiner-Tardivel, Didier Le Roy, Marlies Knaup Reymond, Shizuo Akira, Virginie Petrilli, Carmen E Gomez, Beatriz Perdiguero, Jürg Tschopp, Giuseppe Pantaleo, Mariano Esteban, Thierry Calandra
Published 2009-06-01

Zinc Finger Protein St18 Protects against Septic Death by Inhibiting VEGF-A from Macrophages

by Kenta Maruyama, Hiroyasu Kidoya, Naoki Takemura, Erika Sugisawa, Osamu Takeuchi, Takeshi Kondo, Mohammed Mansour Abbas Eid, Hiroki Tanaka, Mikaël M. Martino, Nobuyuki Takakura, Yasunori Takayama, Shizuo Akira, Alexis Vandenbon, Yutaro Kumagai
Published 2020-07-01

Inflammatory mediator TAK1 regulates hair follicle morphogenesis and anagen induction shown by using keratinocyte-specific TAK1-deficient mice.

by Koji Sayama, Kentaro Kajiya, Koji Sugawara, Shintaro Sato, Satoshi Hirakawa, Yuji Shirakata, Yasushi Hanakawa, Xiuju Dai, Yumiko Ishimatsu-Tsuji, Daniel Metzger, Pierre Chambon, Shizuo Akira, Ralf Paus, Jiro Kishimoto, Koji Hashimoto
Published 2010-01-01

Nociceptors Boost the Resolution of Fungal Osteoinflammation via the TRP Channel-CGRP-Jdp2 Axis

by Kenta Maruyama, Yasunori Takayama, Takeshi Kondo, Ken-ichi Ishibashi, Bikash Ranjan Sahoo, Hisashi Kanemaru, Yutaro Kumagai, Mikaël M. Martino, Hiroki Tanaka, Naohito Ohno, Yoichiro Iwakura, Naoki Takemura, Makoto Tominaga, Shizuo Akira
Published 2017-06-01

An Integrative Framework Reveals Signaling-to-Transcription Events in Toll-like Receptor Signaling

by Philipp Mertins, Dariusz Przybylski, Nir Yosef, Jana Qiao, Karl Clauser, Raktima Raychowdhury, Thomas M. Eisenhaure, Tanja Maritzen, Volker Haucke, Takashi Satoh, Shizuo Akira, Steven A. Carr, Aviv Regev, Nir Hacohen, Nicolas Chevrier
Published 2017-06-01

Prevention of intestinal allergy in mice by rflaA:Ova is associated with enforced antigen processing and TLR5-dependent IL-10 secretion by mDC.

by Stefan Schülke, Sonja Wolfheimer, Gabriele Gadermaier, Andrea Wangorsch, Susanne Siebeneicher, Peter Briza, Ingo Spreitzer, Dirk Schiller, Bettina Loeschner, Satoshi Uematsu, Bernard Ryffel, Shizuo Akira, Zoe Waibler, Stefan Vieths, Masako Toda, Stephan Scheurer
Published 2014-01-01

TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA.

by Hiroyasu Konno, Takuya Yamamoto, Kohsuke Yamazaki, Jin Gohda, Taishin Akiyama, Kentaro Semba, Hideo Goto, Atsushi Kato, Toshiaki Yujiri, Takahiko Imai, Yasushi Kawaguchi, Bing Su, Osamu Takeuchi, Shizuo Akira, Yasuko Tsunetsugu-Yokota, Jun-ichiro Inoue
Published 2009-05-01