FGF19 and FGF21: In NASH we trust

by Saswata Talukdar, Alexei Kharitonenkov
Published 2021-04-01

FGF21 requires βklotho to act in vivo.

by Andrew C Adams, Christine C Cheng, Tamer Coskun, Alexei Kharitonenkov
Published 2012-01-01

Fibroblast growth factor 21 is not required for the reductions in circulating insulin-like growth factor-1 or global cell proliferation rates in response to moderate calorie restri...

by Airlia C S Thompson, Matthew D Bruss, Nitish Nag, Alexei Kharitonenkov, Andrew C Adams, Marc K Hellerstein
Published 2014-01-01

Genetic disruption of uncoupling protein 1 in mice renders brown adipose tissue a significant source of FGF21 secretion

by Susanne Keipert, Maria Kutschke, Daniel Lamp, Laura Brachthäuser, Frauke Neff, Carola W. Meyer, Rebecca Oelkrug, Alexei Kharitonenkov, Martin Jastroch
Published 2015-07-01

Epigenetic reprogramming in Mist1(-/-) mice predicts the molecular response to cerulein-induced pancreatitis.

by Rashid Mehmood, Gabor Varga, Sonali Q Mohanty, Scott W Laing, Yuefeng Lu, Charis L Johnson, Alexei Kharitonenkov, Christopher L Pin
Published 2014-01-01

Discrete Aspects of FGF21 In Vivo Pharmacology Do Not Require UCP1

by Ricardo J. Samms, Dennis P. Smith, Christine C. Cheng, Patrick P. Antonellis, James W. Perfield 2nd, Alexei Kharitonenkov, Ruth E. Gimeno, Andrew C. Adams
Published 2015-05-01

Fundamentals of FGF19 & FGF21 action in vitro and in vivo.

by Andrew C Adams, Tamer Coskun, Armando R Irizarry Rovira, Michael A Schneider, David W Raches, Radmila Micanovic, Holly A Bina, James D Dunbar, Alexei Kharitonenkov
Published 2012-01-01

Molecular elements in FGF19 and FGF21 defining KLB/FGFR activity and specificity

by Archita Agrawal, Sebastian Parlee, Diego Perez-Tilve, Pengyun Li, Jia Pan, Piotr A. Mroz, Ann Maria Kruse Hansen, Birgitte Andersen, Brian Finan, Alexei Kharitonenkov, Richard D. DiMarchi
Published 2018-07-01

LY2405319, an Engineered FGF21 Variant, Improves the Metabolic Status of Diabetic Monkeys.

by Andrew C Adams, Carolyn A Halstead, Barbara C Hansen, Armando R Irizarry, Jennifer A Martin, Sharon R Myers, Vincent L Reynolds, Holly W Smith, Victor J Wroblewski, Alexei Kharitonenkov
Published 2013-01-01

Fibroblast activation protein (FAP) as a novel metabolic target

by Miguel Angel Sánchez-Garrido, Kirk M. Habegger, Christoffer Clemmensen, Cassie Holleman, Timo D. Müller, Diego Perez-Tilve, Pengyun Li, Archita S. Agrawal, Brian Finan, Daniel J. Drucker, Matthias H. Tschöp, Richard D. DiMarchi, Alexei Kharitonenkov
Published 2016-10-01

Glucagon receptor signaling regulates weight loss via central KLB receptor complexes

by Shelly R. Nason, Jessica Antipenko, Natalie Presedo, Stephen E. Cunningham, Tanya H. Pierre, Teayoun Kim, Jodi R. Paul, Cassie Holleman, Martin E. Young, Karen L. Gamble, Brian Finan, Richard DiMarchi, Chad S. Hunter, Alexei Kharitonenkov, Kirk M. Habegger
Published 2021-02-01

Rational design of a fibroblast growth factor 21-based clinical candidate, LY2405319.

by Alexei Kharitonenkov, John M Beals, Radmila Micanovic, Beth A Strifler, Radhakrishnan Rathnachalam, Victor J Wroblewski, Shun Li, Anja Koester, Amy M Ford, Tamer Coskun, James D Dunbar, Christine C Cheng, Christopher C Frye, Thomas F Bumol, David E Moller
Published 2013-01-01