The Paralogue of the Intrinsically Disordered Nuclear Protein 1 Has a Nuclear Localization Sequence that Binds to Human Importin α3

by José L. Neira, Bruno Rizzuti, Ana Jiménez-Alesanco, Olga Abián, Adrián Velázquez-Campoy, Juan L. Iovanna
Published 2020-10-01

A Phosphorylation-Induced Switch in the Nuclear Localization Sequence of the Intrinsically Disordered NUPR1 Hampers Binding to Importin

by José L. Neira, Bruno Rizzuti, Ana Jiménez-Alesanco, Martina Palomino-Schätzlein, Olga Abián, Adrián Velázquez-Campoy, Juan L. Iovanna
Published 2020-09-01

Biosourced All-Acrylic ABA Block Copolymers with Lactic Acid-Based Soft Phase

by Nabil Bensabeh, Ana Jiménez-Alesanco, Ilme Liblikas, Juan C. Ronda, Virginia Cádiz, Marina Galià, Lauri Vares, Olga Abián, Gerard Lligadas
Published 2020-12-01

Sub-Micromolar Inhibition of SARS-CoV-2 3CLpro by Natural Compounds

by Bruno Rizzuti, Laura Ceballos-Laita, David Ortega-Alarcon, Ana Jimenez-Alesanco, Sonia Vega, Fedora Grande, Filomena Conforti, Olga Abian, Adrian Velazquez-Campoy
Published 2021-09-01

Rutin Is a Low Micromolar Inhibitor of SARS-CoV-2 Main Protease 3CLpro: Implications for Drug Design of Quercetin Analogs

by Bruno Rizzuti, Fedora Grande, Filomena Conforti, Ana Jimenez-Alesanco, Laura Ceballos-Laita, David Ortega-Alarcon, Sonia Vega, Hugh T. Reyburn, Olga Abian, Adrian Velazquez-Campoy
Published 2021-04-01

ZZW-115–dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents

by Wenjun Lan, Patricia Santofimia-Castaño, Mirna Swayden, Yi Xia, Zhengwei Zhou, Stephane Audebert, Luc Camoin, Can Huang, Ling Peng, Ana Jiménez-Alesanco, Adrián Velázquez-Campoy, Olga Abián, Gwen Lomberk, Raul Urrutia, Bruno Rizzuti, Vincent Geli, Philippe Soubeyran, José L. Neira, Juan Iovanna
Published 2020-09-01

Seleno-Functionalization of Quercetin Improves the Non-Covalent Inhibition of M^pro and Its Antiviral Activity in Cells against SARS-CoV-2

by Francesca Mangiavacchi, Pawel Botwina, Elena Menichetti, Luana Bagnoli, Ornelio Rosati, Francesca Marini, Sérgio F. Fonseca, Laura Abenante, Diego Alves, Agnieszka Dabrowska, Anna Kula-Pacurar, David Ortega-Alarcon, Ana Jimenez-Alesanco, Laura Ceballos-Laita, Sonia Vega, Bruno Rizzuti, Olga Abian, Eder J. Lenardão, Adrian Velazquez-Campoy, Krzysztof Pyrc, Luca Sancineto, Claudio Santi
Published 2021-06-01