Disruption of Transcriptional Coactivator Sub1 Leads to Genome-Wide Re-distribution of Clustered Mutations Induced by APOBEC in Active Yeast Genes.

by Artem G Lada, Sergei F Kliver, Alok Dhar, Dmitrii E Polev, Alexey E Masharsky, Igor B Rogozin, Youri I Pavlov
Published 2015-05-01

Recombination Is Responsible for the Increased Recovery of Drug-Resistant Mutants with Hypermutated Genomes in Resting Yeast Diploids Expressing APOBEC Deaminases

by Artem G. Lada, Artem G. Lada, Elena I. Stepchenkova, Elena I. Stepchenkova, Elena I. Stepchenkova, Anna S. Zhuk, Anna S. Zhuk, Sergei F. Kliver, Igor B. Rogozin, Igor B. Rogozin, Dmitrii E. Polev, Alok Dhar, Youri I. Pavlov, Youri I. Pavlov, Youri I. Pavlov, Youri I. Pavlov
Published 2017-12-01

Replication protein A (RPA) hampers the processive action of APOBEC3G cytosine deaminase on single-stranded DNA.

by Artem G Lada, Irina S-R Waisertreiger, Corinn E Grabow, Aishwarya Prakash, Gloria E O Borgstahl, Igor B Rogozin, Youri I Pavlov
Published 2011-01-01

Nucleotide Weight Matrices Reveal Ubiquitous Mutational Footprints of AID/APOBEC Deaminases in Human Cancer Genomes

by Igor B. Rogozin, Abiel Roche-Lima, Artem G. Lada, Frida Belinky, Ivan A. Sidorenko, Galina V. Glazko, Vladimir N. Babenko, David N. Cooper, Youri I. Pavlov
Published 2019-02-01

Genome-wide mutation avalanches induced in diploid yeast cells by a base analog or an APOBEC deaminase.

by Artem G Lada, Elena I Stepchenkova, Irina S R Waisertreiger, Vladimir N Noskov, Alok Dhar, James D Eudy, Robert J Boissy, Masayuki Hirano, Igor B Rogozin, Youri I Pavlov
Published 2013-01-01

DNA Methylation, Deamination, and Translesion Synthesis Combine to Generate Footprint Mutations in Cancer Driver Genes in B-Cell Derived Lymphomas and Other Cancers

by Igor B. Rogozin, Abiel Roche-Lima, Kathrin Tyryshkin, Kelvin Carrasquillo-Carrión, Artem G. Lada, Lennard Y. Poliakov, Elena Schwartz, Andreu Saura, Vyacheslav Yurchenko, Vyacheslav Yurchenko, David N. Cooper, Anna R. Panchenko, Youri I. Pavlov, Youri I. Pavlov, Youri I. Pavlov
Published 2021-05-01