Differential Cytokine Responses in Hospitalized COVID-19 Patients Limit Efficacy of Remdesivir

by Yi-Hao Chan, Yi-Hao Chan, Barnaby E. Young, Barnaby E. Young, Barnaby E. Young, Siew-Wai Fong, Siew-Wai Fong, Ying Ding, Yun Shan Goh, Yun Shan Goh, Rhonda Sin-Ling Chee, Rhonda Sin-Ling Chee, Seow-Yen Tan, Shirin Kalimuddin, Shirin Kalimuddin, Paul A. Tambyah, Yee-Sin Leo, Yee-Sin Leo, Yee-Sin Leo, Yee-Sin Leo, Yee-Sin Leo, Lisa F. P. Ng, Lisa F. P. Ng, Lisa F. P. Ng, Lisa F. P. Ng, David Chien Lye, David Chien Lye, David Chien Lye, David Chien Lye, Laurent Renia, Laurent Renia
Published 2021-06-01

Associations of viral ribonucleic acid (RNA) shedding patterns with clinical illness and immune responses in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) infection...

by Pei Hua Lee, Woo Chiao Tay, Stephanie Sutjipto, Siew‐Wai Fong, Sean Wei Xiang Ong, Wycliff Enli Wei, Yi‐Hao Chan, Li Min Ling, Barnaby E Young, Matthias Paul HS Toh, Laurent Renia, Lisa FP Ng, Yee‐Sin Leo, David C Lye, Tau Hong Lee
Published 2020-01-01

Convalescent COVID-19 patients are susceptible to endothelial dysfunction due to persistent immune activation

by Florence WJ Chioh, Siew-Wai Fong, Barnaby E Young, Kan-Xing Wu, Anthony Siau, Shuba Krishnan, Yi-Hao Chan, Guillaume Carissimo, Louis LY Teo, Fei Gao, Ru San Tan, Liang Zhong, Angela S Koh, Seow-Yen Tan, Paul A Tambyah, Laurent Renia, Lisa FP Ng, David C Lye, Christine Cheung
Published 2021-03-01

A Virus-Specific Immune Rheostat in the Immunome of Patients Recovering From Mild COVID-19

by Joo Guan Yeo, Joo Guan Yeo, Joo Guan Yeo, Jing Yao Leong, Shi Huan Tay, Shi Huan Tay, Karen Donceras Nadua, Karen Donceras Nadua, Karen Donceras Nadua, Danielle E. Anderson, Amanda Jin Mei Lim, Xiang Wen Ng, Su Li Poh, Dianyan Guo, Katherine Nay Yaung, Katherine Nay Yaung, Pavanish Kumar, Martin Wasser, Sharifah Nur Hazirah, Nursyuhadah Sutamam, Camillus Jian Hui Chua, Martin Qui, Randy Foo, Akshamal Mihiranga Gamage, Kee Thai Yeo, Kee Thai Yeo, Kee Thai Yeo, Lakshmi Ramakrishna, Thaschawee Arkachaisri, Thaschawee Arkachaisri, Thaschawee Arkachaisri, Barnaby E. Young, Barnaby E. Young, Barnaby E. Young, David Chien Lye, David Chien Lye, David Chien Lye, David Chien Lye, Lin-Fa Wang, Chia Yin Chong, Chia Yin Chong, Chia Yin Chong, Chia Yin Chong, Natalie Woon Hui Tan, Natalie Woon Hui Tan, Natalie Woon Hui Tan, Natalie Woon Hui Tan, Jiahui Li, Jiahui Li, Jiahui Li, Kai-Qian Kam, Kai-Qian Kam, Kai-Qian Kam, Florent Ginhoux, Florent Ginhoux, Florent Ginhoux, Koh Cheng Thoon, Koh Cheng Thoon, Koh Cheng Thoon, Koh Cheng Thoon, Jerry Kok Yen Chan, Jerry Kok Yen Chan, Chee Fu Yung, Chee Fu Yung, Chee Fu Yung, Salvatore Albani, Salvatore Albani, Salvatore Albani
Published 2021-05-01

Discovery and Genomic Characterization of a 382-Nucleotide Deletion in ORF7b and ORF8 during the Early Evolution of SARS-CoV-2

by Yvonne C. F. Su, Danielle E. Anderson, Barnaby E. Young, Martin Linster, Feng Zhu, Jayanthi Jayakumar, Yan Zhuang, Shirin Kalimuddin, Jenny G. H. Low, Chee Wah Tan, Wan Ni Chia, Tze Minn Mak, Sophie Octavia, Jean-Marc Chavatte, Raphael T. C. Lee, Surinder Pada, Seow Yen Tan, Louisa Sun, Gabriel Z. Yan, Sebastian Maurer-Stroh, Ian H. Mendenhall, Yee-Sin Leo, David Chien Lye, Lin-Fa Wang, Gavin J. D. Smith
Published 2020-07-01

Association of SARS-CoV-2 clades with clinical, inflammatory and virologic outcomes: An observational study

by Barnaby E Young, Wycliffe E Wei, Siew-Wai Fong, Tze-Minn Mak, Danielle E Anderson, Yi-Hao Chan, Rachael Pung, Cheryl SY Heng, Li Wei Ang, Adrian Kang Eng Zheng, Bernett Lee, Shirin Kalimuddin, Surinder Pada, Paul A Tambyah, Purnima Parthasarathy, Seow Yen Tan, Louisa Sun, Gavin JD Smith, Raymond Tzer Pin Lin, Yee-Sin Leo, Laurent Renia, Lin-Fa Wang, Lisa FP Ng, Sebastian Maurer-Stroh, David Chien Lye, Vernon J Lee
Published 2021-04-01

The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the optimal therapeut...

by Conrad E Z Chan, Shirley G K Seah, De Hoe Chye, Shane Massey, Maricela Torres, Angeline P C Lim, Steven K K Wong, Jacklyn J Y Neo, Pui San Wong, Jie Hui Lim, Gary S L Loh, Dongling Wang, Jerome D Boyd-Kirkup, Siyu Guan, Dipti Thakkar, Guo Hui Teo, Kiren Purushotorman, Paul E Hutchinson, Barnaby E Young, Jenny G Low, Paul A MacAry, Hannes Hentze, Venkateshan S Prativadibhayankara, Kantharaj Ethirajulu, Jason E Comer, Chien-Te K Tseng, Alan D T Barrett, Piers J Ingram, Trevor Brasel, Brendon John Hanson
Published 2021-01-01