The C-type lectin receptor Mincle binds to Streptococcus pneumoniae but plays a limited role in the anti-pneumococcal innate immune response.

by Anne Rabes, Stephanie Zimmermann, Katrin Reppe, Roland Lang, Peter H Seeberger, Norbert Suttorp, Martin Witzenrath, Bernd Lepenies, Bastian Opitz
Published 2015-01-01

Rac1 regulates the NLRP3 inflammasome which mediates IL-1beta production in Chlamydophila pneumoniae infected human mononuclear cells.

by Julia Eitel, Karolin Meixenberger, Claudia van Laak, Christine Orlovski, Andreas Hocke, Bernd Schmeck, Stefan Hippenstiel, Philippe Dje N'Guessan, Norbert Suttorp, Bastian Opitz
Published 2012-01-01

Ventilator-induced lung injury is aggravated by antibiotic mediated microbiota depletion in mice

by Sandra-Maria Wienhold, Mario Macrì, Geraldine Nouailles, Kristina Dietert, Corinne Gurtner, Achim D Gruber, Markus M Heimesaat, Jasmin Lienau, Fabian Schumacher, Burkhard Kleuser, Bastian Opitz, Norbert Suttorp, Martin Witzenrath, Holger C Müller-Redetzky
Published 2018-10-01

The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires' disease in humans.

by Juan S Ruiz-Moreno, Lutz Hamann, Javeed A Shah, Annelies Verbon, Frank P Mockenhaupt, Monika Puzianowska-Kuznicka, Jan Naujoks, Leif E Sander, Martin Witzenrath, John C Cambier, Norbert Suttorp, Ralf R Schumann, Lei Jin, Thomas R Hawn, Bastian Opitz, CAPNETZ Study Group
Published 2018-01-01

Serotype 1 and 8 Pneumococci Evade Sensing by Inflammasomes in Human Lung Tissue.

by Diana Fatykhova, Anne Rabes, Christoph Machnik, Kunchur Guruprasad, Florence Pache, Johanna Berg, Mario Toennies, Torsten T Bauer, Paul Schneider, Maria Schimek, Stephan Eggeling, Timothy J Mitchell, Andrea M Mitchell, Rolf Hilker, Torsten Hain, Norbert Suttorp, Stefan Hippenstiel, Andreas C Hocke, Bastian Opitz
Published 2015-01-01

Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia.

by Kristina Dietert, Birgitt Gutbier, Sandra M Wienhold, Katrin Reppe, Xiaohui Jiang, Ling Yao, Catherine Chaput, Jan Naujoks, Markus Brack, Alexandra Kupke, Christin Peteranderl, Stephan Becker, Carolin von Lachner, Nelli Baal, Hortense Slevogt, Andreas C Hocke, Martin Witzenrath, Bastian Opitz, Susanne Herold, Holger Hackstein, Leif E Sander, Norbert Suttorp, Achim D Gruber
Published 2017-01-01

IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid.

by Jan Naujoks, Christoph Tabeling, Brian D Dill, Christine Hoffmann, Andrew S Brown, Mareike Kunze, Stefan Kempa, Andrea Peter, Hans-Joachim Mollenkopf, Anca Dorhoi, Olivia Kershaw, Achim D Gruber, Leif E Sander, Martin Witzenrath, Susanne Herold, Andreas Nerlich, Andreas C Hocke, Ian van Driel, Norbert Suttorp, Sammy Bedoui, Hubert Hilbi, Matthias Trost, Bastian Opitz
Published 2016-02-01