Natural Products as Targeted Modulators of the Immune System

by Kai Wang, Michael Conlon, Wenkai Ren, Bill B. Chen, Tomasz Bączek
Published 2018-01-01

Novel PDE4 inhibitors derived from Chinese medicine forsythia.

by Tiffany A Coon, Alison C McKelvey, Nate M Weathington, Rahel L Birru, Travis Lear, George D Leikauf, Bill B Chen
Published 2014-01-01

A small molecule NRF2 activator BC-1901S ameliorates inflammation through DCAF1/NRF2 axis

by Yanwen Chen, John W. Evankovich, Travis B. Lear, Ferhan Tuncer, Jason R. Kennerdell, Daniel P. Camarco, Morgan S. Shishido, Yuan Liu, Bill B. Chen
Published 2020-05-01

Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity

by Joseph S. Bednash, Nathaniel Weathington, James Londino, Mauricio Rojas, Dexter L. Gulick, Robert Fort, SeungHye Han, Alison C. McKelvey, Bill B. Chen, Rama K. Mallampalli
Published 2017-05-01

RING finger E3 ligase PPP1R11 regulates TLR2 signaling and innate immunity

by Alison C McKelvey, Travis B Lear, Sarah R Dunn, John Evankovich, James D Londino, Joseph S Bednash, Yingze Zhang, Bryan J McVerry, Yuan Liu, Bill B Chen
Published 2016-11-01

The mito-DAMP cardiolipin blocks IL-10 production causing persistent inflammation during bacterial pneumonia

by Krishnendu Chakraborty, Mahesh Raundhal, Bill B. Chen, Christina Morse, Yulia Y. Tyurina, Anupriya Khare, Timothy B. Oriss, Rachael Huff, Janet S. Lee, Claudette M. St. Croix, Simon Watkins, Rama K. Mallampalli, Valerian E. Kagan, Anuradha Ray, Prabir Ray
Published 2017-01-01

A high-throughput screen for TMPRSS2 expression identifies FDA-approved compounds that can limit SARS-CoV-2 entry

by Yanwen Chen, Travis B. Lear, John W. Evankovich, Mads B. Larsen, Bo Lin, Irene Alfaras, Jason R. Kennerdell, Laura Salminen, Daniel P. Camarco, Karina C. Lockwood, Ferhan Tuncer, Jie Liu, Michael M. Myerburg, John F. McDyer, Yuan Liu, Toren Finkel, Bill B. Chen
Published 2021-06-01

E3 Ligase Subunit Fbxo15 and PINK1 Kinase Regulate Cardiolipin Synthase 1 Stability and Mitochondrial Function in Pneumonia

by Bill B. Chen, Tiffany A. Coon, Jennifer R. Glasser, Chunbin Zou, Bryon Ellis, Tuhin Das, Alison C. McKelvey, Shristi Rajbhandari, Travis Lear, Christelle Kamga, Sruti Shiva, Chenjian Li, Joseph M. Pilewski, Jason Callio, Charleen T. Chu, Anuradha Ray, Prabir Ray, Yulia Y. Tyurina, Valerian E. Kagan, Rama K. Mallampalli
Published 2014-04-01