The role of tumour heterogeneity and clonal cooperativity in metastasis, immune evasion and clinical outcome

by Deborah R. Caswell, Charles Swanton
Published 2017-07-01

Review: Systemic therapy for advanced renal cell carcinoma

by James M.G. Larkin, Emma L.S. Kipps, Ceri J. Powell, Charles Swanton
Published 2009-07-01

Progress towards non-small-cell lung cancer models that represent clinical evolutionary trajectories

by Robert E. Hynds, Kristopher K. Frese, David R. Pearce, Eva Grönroos, Caroline Dive, Charles Swanton
Published 2021-01-01

Quantification of tumour evolution and heterogeneity via Bayesian epiallele detection

by James E. Barrett, Andrew Feber, Javier Herrero, Miljana Tanic, Gareth A. Wilson, Charles Swanton, Stephan Beck
Published 2017-07-01

Minimising immunohistochemical false negative ER classification using a complementary 23 gene expression signature of ER status.

by Qiyuan Li, Aron C Eklund, Nicolai Juul, Benjamin Haibe-Kains, Christopher T Workman, Andrea L Richardson, Zoltan Szallasi, Charles Swanton
Published 2010-12-01

The CIN4 chromosomal instability qPCR classifier defines tumor aneuploidy and stratifies outcome in grade 2 breast cancer.

by Attila Marcell Szász, Qiyuan Li, Aron C Eklund, Zsófia Sztupinszki, Andrew Rowan, Anna-Mária Tőkés, Borbála Székely, András Kiss, Miklós Szendrői, Balázs Győrffy, Zoltán Szállási, Charles Swanton, Janina Kulka
Published 2013-01-01

Genomic instability in mutant p53 cancer cells upon entotic engulfment

by Hannah L. Mackay, David Moore, Callum Hall, Nicolai J. Birkbak, Mariam Jamal-Hanjani, Saadia A. Karim, Vinaya M. Phatak, Lucia Piñon, Jennifer P. Morton, Charles Swanton, John Le Quesne, Patricia A. J. Muller
Published 2018-08-01

Publisher Correction: Genomic instability in mutant p53 cancer cells upon entotic engulfment

by Hannah L. Mackay, David Moore, Callum Hall, Nicolai J. Birkbak, Mariam Jamal-Hanjani, Saadia A. Karim, Vinaya M. Phatak, Lucia Piñon, Jennifer P. Morton, Charles Swanton, John Le Quesne, Patricia A. J. Muller
Published 2018-08-01

Prospective analysis of 895 patients on a UK Genomics Review Board

by David Allan Moore, Marina Kushnir, Gabriel Mak, Helen Winter, Teresa Curiel, Mark Voskoboynik, Michele Moschetta, Nataliya Rozumna-Martynyuk, Kevin Balbi, Philip Bennett, Martin Forster, Anjana Kulkarni, Debra Haynes, Charles Swanton, Hendrik-Tobias Arkenau
Published 2019-04-01

Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses

by Julianna Blagih, Fabio Zani, Probir Chakravarty, Marc Hennequart, Steven Pilley, Sebastijan Hobor, Andreas K. Hock, Josephine B. Walton, Jennifer P. Morton, Eva Gronroos, Susan Mason, Ming Yang, Iain McNeish, Charles Swanton, Karen Blyth, Karen H. Vousden
Published 2020-01-01

Circulating tumour DNA in metastatic breast cancer to guide clinical trial enrolment and precision oncology: A cohort study

by Andjelija Zivanovic Bujak, Chen-Fang Weng, Maria João Silva, Miriam Yeung, Louisa Lo, Sarah Ftouni, Cassandra Litchfield, Yi-An Ko, Keilly Kuykhoven, Courtney Van Geelen, Sushma Chandrashekar, Mark A. Dawson, Sherene Loi, Stephen Q. Wong, Sarah-Jane Dawson, Charles Swanton
Published 2020-10-01

Selective inhibition of cancer cell self-renewal through a Quisinostat-histone H1.0 axis

by Cristina Morales Torres, Mary Y. Wu, Sebastijan Hobor, Elanor N. Wainwright, Matthew J. Martin, Harshil Patel, William Grey, Eva Grönroos, Steven Howell, Joana Carvalho, Ambrosius P. Snijders, Michael Bustin, Dominique Bonnet, Paul D. Smith, Charles Swanton, Michael Howell, Paola Scaffidi
Published 2020-04-01

Characterisation of tumour microenvironment remodelling following oncogene inhibition in preclinical studies with imaging mass cytometry

by Febe van Maldegem, Karishma Valand, Megan Cole, Harshil Patel, Mihaela Angelova, Sareena Rana, Emma Colliver, Katey Enfield, Nourdine Bah, Gavin Kelly, Victoria Siu Kwan Tsang, Edurne Mugarza, Christopher Moore, Philip Hobson, Dina Levi, Miriam Molina-Arcas, Charles Swanton, Julian Downward
Published 2021-10-01

Clonal Evolutionary Analysis during HER2 Blockade in HER2-Positive Inflammatory Breast Cancer: A Phase II Open-Label Clinical Trial of Afatinib +/- Vinorelbine.

by Gerald Goh, Ramona Schmid, Kelly Guiver, Wichit Arpornwirat, Imjai Chitapanarux, Vinod Ganju, Seock-Ah Im, Sung-Bae Kim, Arunee Dechaphunkul, Jedzada Maneechavakajorn, Neil Spector, Thomas Yau, Mehdi Afrit, Slim Ben Ahmed, Stephen R Johnston, Neil Gibson, Martina Uttenreuther-Fischer, Javier Herrero, Charles Swanton
Published 2016-12-01

The Subclonal Architecture of Metastatic Breast Cancer: Results from a Prospective Community-Based Rapid Autopsy Program "CASCADE".

by Peter Savas, Zhi Ling Teo, Christophe Lefevre, Christoffer Flensburg, Franco Caramia, Kathryn Alsop, Mariam Mansour, Prudence A Francis, Heather A Thorne, Maria Joao Silva, Nnennaya Kanu, Michelle Dietzen, Andrew Rowan, Maik Kschischo, Stephen Fox, David D Bowtell, Sarah-Jane Dawson, Terence P Speed, Charles Swanton, Sherene Loi
Published 2016-12-01

Correction: The Subclonal Architecture of Metastatic Breast Cancer: Results from a Prospective Community-Based Rapid Autopsy Program "CASCADE".

by Peter Savas, Zhi Ling Teo, Christophe Lefevre, Christoffer Flensburg, Franco Caramia, Kathryn Alsop, Mariam Mansour, Prudence A Francis, Heather A Thorne, Maria Joao Silva, Nnennaya Kanu, Michelle Dietzen, Andrew Rowan, Maik Kschischo, Stephen Fox, David D Bowtell, Sarah-Jane Dawson, Terence P Speed, Charles Swanton, Sherene Loi
Published 2017-04-01

Escape from nonsense-mediated decay associates with anti-tumor immunogenicity

by Kevin Litchfield, James L. Reading, Emilia L. Lim, Hang Xu, Po Liu, Maise Al-Bakir, Yien Ning Sophia Wong, Andrew Rowan, Samuel A. Funt, Taha Merghoub, David Perkins, Martin Lauss, Inge Marie Svane, Göran Jönsson, Javier Herrero, James Larkin, Sergio A. Quezada, Matthew D. Hellmann, Samra Turajlic, Charles Swanton
Published 2020-07-01

Genomic landscape of platinum resistant and sensitive testicular cancers

by Chey Loveday, Kevin Litchfield, Paula Z. Proszek, Alex J. Cornish, Flavia Santo, Max Levy, Geoff Macintyre, Amy Holryod, Peter Broderick, Darshna Dudakia, Barbara Benton, Maise Al Bakir, Crispin Hiley, Emily Grist, Charles Swanton, Robert Huddart, Tom Powles, Simon Chowdhury, Janet Shipley, Simon O’Connor, James D. Brenton, Alison Reid, David Gonzalez de Castro, Richard S. Houlston, Clare Turnbull
Published 2020-05-01

Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling

by Inma M. Berenjeno, Roberto Piñeiro, Sandra D. Castillo, Wayne Pearce, Nicholas McGranahan, Sally M. Dewhurst, Valerie Meniel, Nicolai J. Birkbak, Evelyn Lau, Laurent Sansregret, Daniele Morelli, Nnennaya Kanu, Shankar Srinivas, Mariona Graupera, Victoria E. R. Parker, Karen G. Montgomery, Larissa S. Moniz, Cheryl L. Scudamore, Wayne A. Phillips, Robert K. Semple, Alan Clarke, Charles Swanton, Bart Vanhaesebroeck
Published 2017-11-01

The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis

by Hannah V. Woodcock, Jessica D. Eley, Delphine Guillotin, Manuela Platé, Carmel B. Nanthakumar, Matteo Martufi, Simon Peace, Gerard Joberty, Daniel Poeckel, Robert B. Good, Adam R. Taylor, Nico Zinn, Matthew Redding, Ellen J. Forty, Robert E. Hynds, Charles Swanton, Morten Karsdal, Toby M. Maher, Andrew Fisher, Giovanna Bergamini, Richard P. Marshall, Andy D. Blanchard, Paul F. Mercer, Rachel C. Chambers
Published 2019-01-01