Structural characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei bound to the antifungal drugs posaconazole and fluconazole.

by Chiung-Kuang Chen, Siegfried S F Leung, Christophe Guilbert, Matthew P Jacobson, James H McKerrow, Larissa M Podust
Published 2010-04-01

Trypanosoma cruzi CYP51 inhibitor derived from a Mycobacterium tuberculosis screen hit.

by Chiung-Kuang Chen, Patricia S Doyle, Liudmila V Yermalitskaya, Zachary B Mackey, Kenny K H Ang, James H McKerrow, Larissa M Podust
Published 2009-01-01

Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51.

by Shamila S Gunatilleke, Claudia M Calvet, Jonathan B Johnston, Chiung-Kuang Chen, Grigori Erenburg, Jiri Gut, Juan C Engel, Kenny K H Ang, Joseph Mulvaney, Steven Chen, Michelle R Arkin, James H McKerrow, Larissa M Podust
Published 2012-01-01