Granulin knock out zebrafish lack frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis pathology.

by Barbara Solchenberger, Claire Russell, Elisabeth Kremmer, Christian Haass, Bettina Schmid
Published 2015-01-01

Endoproteolysis of the ER Stress Transducer ATF6 in the Presence of Functionally Inactive Presenilins

by Harald Steiner, Edith Winkler, Mark S. Shearman, Ron Prywes, Christian Haass
Published 2001-08-01

Pathological activity of familial Alzheimer’s disease-associated mutant presenilin can be executed by six different γ-secretase complexes

by Keiro Shirotani, Masanori Tomioka, Elisabeth Kremmer, Christian Haass, Harald Steiner
Published 2007-07-01

Glial Activation Markers in CSF and Serum From Patients With Primary Progressive Multiple Sclerosis: Potential of Serum GFAP as Disease Severity Marker?

by Ahmed Abdelhak, Ahmed Abdelhak, Tilman Hottenrott, Estrella Morenas-Rodríguez, Estrella Morenas-Rodríguez, Marc Suárez-Calvet, Uwe K. Zettl, Christian Haass, Christian Haass, Christian Haass, Sven G. Meuth, Sebastian Rauer, Markus Otto, Hayrettin Tumani, Hayrettin Tumani, André Huss
Published 2019-03-01

Methylene blue fails to inhibit Tau and polyglutamine protein dependent toxicity in zebrafish

by Frauke van Bebber, Dominik Paquet, Alexander Hruscha, Bettina Schmid, Christian Haass
Published 2010-09-01

Comparison of 18F-T807 and 18F-THK5117 PET in a Mouse Model of Tau Pathology

by Matthias Brendel, Behrooz H. Yousefi, Behrooz H. Yousefi, Tanja Blume, Michael Herz, Carola Focke, Maximilian Deussing, Finn Peters, Simon Lindner, Barbara von Ungern-Sternberg, Alexander Drzezga, Peter Bartenstein, Peter Bartenstein, Christian Haass, Christian Haass, Christian Haass, Nobuyuki Okamura, Jochen Herms, Jochen Herms, Igor Yakushev, Igor Yakushev, Axel Rominger, Axel Rominger
Published 2018-06-01

Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice

by Julia K. Götzl, Alessio-Vittorio Colombo, Katrin Fellerer, Anika Reifschneider, Georg Werner, Sabina Tahirovic, Christian Haass, Anja Capell
Published 2018-09-01

Parkin is protective against proteotoxic stress in a transgenic zebrafish model.

by Mareike E Fett, Anna Pilsl, Dominik Paquet, Frauke van Bebber, Christian Haass, Jörg Tatzelt, Bettina Schmid, Konstanze F Winklhofer
Published 2010-07-01

Dual-Phase β-Amyloid PET Captures Neuronal Injury and Amyloidosis in Corticobasal Syndrome

by Julia Schmitt, Carla Palleis, Julia Sauerbeck, Marcus Unterrainer, Stefanie Harris, Catharina Prix, Endy Weidinger, Sabrina Katzdobler, Olivia Wagemann, Adrian Danek, Leonie Beyer, Boris-Stephan Rauchmann, Boris-Stephan Rauchmann, Axel Rominger, Axel Rominger, Axel Rominger, Mikael Simons, Mikael Simons, Mikael Simons, Peter Bartenstein, Peter Bartenstein, Robert Perneczky, Robert Perneczky, Robert Perneczky, Robert Perneczky, Christian Haass, Christian Haass, Christian Haass, Johannes Levin, Johannes Levin, Johannes Levin, Günter U. Höglinger, Günter U. Höglinger, Günter U. Höglinger, Matthias Brendel, Matthias Brendel, the German Imaging Initiative for Tauopathies (GII4T)
Published 2021-05-01

Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein

by Saoussen Ben Halima, Sabyashachi Mishra, K. Muruga Poopathi Raja, Michael Willem, Antonio Baici, Kai Simons, Oliver Brüstle, Philipp Koch, Christian Haass, Amedeo Caflisch, Lawrence Rajendran
Published 2016-03-01

Nuclear import factor transportin and arginine methyltransferase 1 modify FUS neurotoxicity in Drosophila

by Sandra Jäckel, Anna K. Summerer, Catherine M. Thömmes, Xia Pan, Aaron Voigt, Jörg B. Schulz, Tobias M. Rasse, Dorothee Dormann, Christian Haass, Philipp J. Kahle
Published 2015-02-01

CSF glial biomarkers YKL40 and sTREM2 are associated with longitudinal volume and diffusivity changes in cognitively unimpaired individuals

by Carles Falcon, Gemma C. Monté-Rubio, Oriol Grau-Rivera, Marc Suárez-Calvet, Raquel Sánchez-Valle, Lorena Rami, Beatriz Bosch, Christian Haass, Juan Domingo Gispert, José Luis Molinuevo
Published 2019-01-01

The Trem2 R47H Alzheimer’s risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans

by Xianyuan Xiang, Thomas M. Piers, Benedikt Wefers, Kaichuan Zhu, Anna Mallach, Bettina Brunner, Gernot Kleinberger, Wilbur Song, Marco Colonna, Jochen Herms, Wolfgang Wurst, Jennifer M. Pocock, Christian Haass
Published 2018-09-01

Cross-sectional comparison of small animal [18F]-florbetaben amyloid-PET between transgenic AD mouse models.

by Matthias Brendel, Anna Jaworska, Eric Grießinger, Christina Rötzer, Steffen Burgold, Franz-Josef Gildehaus, Janette Carlsen, Paul Cumming, Karlheinz Baumann, Christian Haass, Harald Steiner, Peter Bartenstein, Jochen Herms, Axel Rominger
Published 2015-01-01

The Alzheimer’s disease-associated protective Plcγ2-P522R variant promotes immune functions

by Mari Takalo, Rebekka Wittrahm, Benedikt Wefers, Samira Parhizkar, Kimmo Jokivarsi, Teemu Kuulasmaa, Petra Mäkinen, Henna Martiskainen, Wolfgang Wurst, Xianyuan Xiang, Mikael Marttinen, Pekka Poutiainen, Annakaisa Haapasalo, Mikko Hiltunen, Christian Haass
Published 2020-09-01

FAS-dependent cell death in α-synuclein transgenic oligodendrocyte models of multiple system atrophy.

by Christine L Kragh, Gwenaëlle Fillon, Amanda Gysbers, Hanne D Hansen, Manuela Neumann, Christiane Richter-Landsberg, Christian Haass, Bernard Zalc, Catherine Lubetzki, Wei-Ping Gai, Glenda M Halliday, Philipp J Kahle, Poul H Jensen
Published 2013-01-01

Heterogeneous ribonuclear protein A3 (hnRNP A3) is present in dipeptide repeat protein containing inclusions in Frontotemporal Lobar Degeneration and Motor Neurone disease associat...

by Yvonne S. Davidson, Louis Flood, Andrew C. Robinson, Yoshihiro Nihei, Kohji Mori, Sara Rollinson, Anna Richardson, Bridget C. Benson, Matthew Jones, Julie S. Snowden, Stuart Pickering-Brown, Christian Haass, Tammaryn Lashley, David M. A. Mann
Published 2017-04-01

Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration

by Nicolai Franzmeier, M. Suárez-Calvet, Lukas Frontzkowski, Annah Moore, Timothy J. Hohman, Estrella Morenas-Rodriguez, Brigitte Nuscher, Leslie Shaw, John Q. Trojanowski, Martin Dichgans, Gernot Kleinberger, Christian Haass, Michael Ewers, for the Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Published 2020-10-01

Active poly‐GA vaccination prevents microglia activation and motor deficits in a C9orf72 mouse model

by Qihui Zhou, Nikola Mareljic, Meike Michaelsen, Samira Parhizkar, Steffanie Heindl, Brigitte Nuscher, Daniel Farny, Mareike Czuppa, Carina Schludi, Alexander Graf, Stefan Krebs, Helmut Blum, Regina Feederle, Stefan Roth, Christian Haass, Thomas Arzberger, Arthur Liesz, Dieter Edbauer
Published 2020-02-01

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

by Marcia B. Podlisny, Martin Citron, Patricia Amarante, Robin Sherrington, Weiming Xia, Jimin Zhang, Thekla Diehl, George Levesque, Paul Fraser, Christian Haass, Edward H.M. Koo, Peter Seubert, Peter St. George-Hyslop, David B. Teplow, Dennis J. Selkoe
Published 1997-01-01