Genetic dissection of endothelial transcriptional activity of zebrafish aryl hydrocarbon receptors (AHRs).

by Wade W Sugden, Roberto C Leonardo-Mendonça, Darío Acuña-Castroviejo, Arndt F Siekmann
Published 2017-01-01

Melatonin Mitigates Mitochondrial Meltdown: Interactions with SIRT3

by Russel J. Reiter, Dun Xian Tan, Sergio Rosales-Corral, Annia Galano, Mei-Jie Jou, Dario Acuna-Castroviejo
Published 2018-08-01

A phase II, single-center, double-blind, randomized placebo-controlled trial to explore the efficacy and safety of intravenous melatonin in patients with COVID-19 admitted to the i...

by Miguel Rodríguez-Rubio, Juan Carlos Figueira, Darío Acuña-Castroviejo, Alberto M. Borobia, Germaine Escames, Pedro de la Oliva
Published 2020-08-01

Protective Effects of Melatonin on the Skin: Future Perspectives

by Iryna Rusanova, Laura Martínez-Ruiz, Javier Florido, César Rodríguez-Santana, Ana Guerra-Librero, Darío Acuña-Castroviejo, Germaine Escames
Published 2019-10-01

Rapamycin administration is not a valid therapeutic strategy for every case of mitochondrial diseaseResearch in context

by Eliana Barriocanal-Casado, Agustín Hidalgo-Gutiérrez, Nuno Raimundo, Pilar González-García, Darío Acuña-Castroviejo, Germaine Escames, Luis C. López
Published 2019-04-01

Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis

by Russel J. Reiter, Sergio A. Rosales-Corral, Dun-Xian Tan, Dario Acuna-Castroviejo, Lilan Qin, Shun-Fa Yang, Kexin Xu
Published 2017-04-01

Melatonin/Nrf2/NLRP3 Connection in Mouse Heart Mitochondria during Aging

by Marisol Fernández-Ortiz, Ramy K. A. Sayed, José Fernández-Martínez, Antonia Cionfrini, Paula Aranda-Martínez, Germaine Escames, Tomás de Haro, Darío Acuña-Castroviejo
Published 2020-11-01

The Melatonin Analog IQM316 May Induce Adult Hippocampal Neurogenesis and Preserve Recognition Memories in Mice

by Joana Figueiro-Silva, Desireé Antequera, Consuelo Pascual, Mario de la Fuente Revenga, Huayqui Volt, Darío Acuña-Castroviejo, María Isabel Rodríguez-Franco, Eva Carro
Published 2018-03-01

Melatonin Treatment Reduces Oxidative Damage and Normalizes Plasma Pro-Inflammatory Cytokines in Patients Suffering from Charcot-Marie-Tooth Neuropathy: A Pilot Study in Three Chil...

by Mariam Chahbouni, María del Señor López, Antonio Molina-Carballo, Tomás de Haro, Antonio Muñoz-Hoyos, Marisol Fernández-Ortiz, Ana Guerra-Librero, Darío Acuña-Castroviejo
Published 2017-10-01

Analysis of Plasma MicroRNAs as Predictors and Biomarkers of Aging and Frailty in Humans

by Iryna Rusanova, María E. Diaz-Casado, Marisol Fernández-Ortiz, Paula Aranda-Martínez, Ana Guerra-Librero, Francisco J. García-García, Germaine Escames, Leocadio Mañas, Darío Acuña-Castroviejo
Published 2018-01-01

Accumulation of Exogenous Amyloid-Beta Peptide in Hippocampal Mitochondria Causes Their Dysfunction: A Protective Role for Melatonin

by Sergio Rosales-Corral, Dario Acuna-Castroviejo, Dun Xian Tan, Gabriela López-Armas, José Cruz-Ramos, Rubén Munoz, Valery G. Melnikov, Lucien C. Manchester, Russel J. Reiter
Published 2012-01-01

The Impact of Melatonin Supplementation and NLRP3 Inflammasome Deletion on Age-Accompanied Cardiac Damage

by Ramy K. A. Sayed, Marisol Fernández-Ortiz, Ibtissem Rahim, José Fernández-Martínez, Paula Aranda-Martínez, Iryna Rusanova, Laura Martínez-Ruiz, Reem M. Alsaadawy, Germaine Escames, Darío Acuña-Castroviejo
Published 2021-08-01

The Impact of Melatonin and NLRP3 Inflammasome on the Expression of microRNAs in Aged Muscle

by Ramy KA Sayed, Marisol Fernández-Ortiz, José Fernández-Martínez, Paula Aranda Martínez, Ana Guerra-Librero, César Rodríguez-Santana, Tomás de Haro, Germaine Escames, Darío Acuña-Castroviejo, Iryna Rusanova
Published 2021-03-01

Prophylactic Role of Oral Melatonin Administration on Neurogenesis in Adult Balb/C Mice during REM Sleep Deprivation

by Gabriela López-Armas, Mario Eduardo Flores-Soto, Verónica Chaparro-Huerta, Luis Felipe Jave-Suarez, Sofía Soto-Rodríguez, Iryna Rusanova, Dario Acuña-Castroviejo, Oscar González-Perez, Rocío Elizabeth González-Castañeda
Published 2016-01-01

Fluorination Effects on NOS Inhibitory Activity of Pyrazoles Related to Curcumin

by Carla I. Nieto, María Pilar Cabildo, María Pilar Cornago, Dionisia Sanz, Rosa M. Claramunt, María Carmen Torralba, María Rosario Torres, José Elguero, José A. García, Ana López, Darío Acuña-Castroviejo
Published 2015-08-01

Mitochondrial impairment and melatonin protection in parkinsonian mice do not depend of inducible or neuronal nitric oxide synthases.

by Ana López, Francisco Ortiz, Carolina Doerrier, Carmen Venegas, Marisol Fernández-Ortiz, Paula Aranda, María E Díaz-Casado, Beatriz Fernández-Gil, Eliana Barriocanal-Casado, Germaine Escames, Luis C López, Darío Acuña-Castroviejo
Published 2017-01-01

β‐RA reduces DMQ/CoQ ratio and rescues the encephalopathic phenotype in Coq9R239X mice

by Agustín Hidalgo‐Gutiérrez, Eliana Barriocanal‐Casado, Mohammed Bakkali, M Elena Díaz‐Casado, Laura Sánchez‐Maldonado, Miguel Romero, Ramy K Sayed, Cornelia Prehn, Germaine Escames, Juan Duarte, Darío Acuña‐Castroviejo, Luis C López
Published 2019-01-01

Melatonin Targets Metabolism in Head and Neck Cancer Cells by Regulating Mitochondrial Structure and Function

by Ana Guerra-Librero, Beatriz I. Fernandez-Gil, Javier Florido, Laura Martinez-Ruiz, César Rodríguez-Santana, Ying-Qiang Shen, José M. García-Verdugo, Alba López-Rodríguez, Iryna Rusanova, Alfredo Quiñones-Hinojosa, Darío Acuña-Castroviejo, Jordi Marruecos, Tomás De Haro, Germaine Escames
Published 2021-04-01

Melatonin Enhances Cisplatin and Radiation Cytotoxicity in Head and Neck Squamous Cell Carcinoma by Stimulating Mitochondrial ROS Generation, Apoptosis, and Autophagy

by Beatriz I. Fernandez-Gil, Ana Guerra-Librero, Ying-Qiang Shen, Javier Florido, Laura Martínez-Ruiz, Sergio García-López, Christian Adan, César Rodríguez-Santana, Darío Acuña-Castroviejo, Alfredo Quiñones-Hinojosa, José Fernández-Martínez, Ahmed E. Abdel Moneim, Luis C. López, José M. Rodríguez Ferrer, Germaine Escames
Published 2019-01-01

Melatonin protects rats from radiotherapy-induced small intestine toxicity.

by Beatriz Fernández-Gil, Ahmed E Abdel Moneim, Francisco Ortiz, Ying-Qiang Shen, Viviana Soto-Mercado, Miguel Mendivil-Perez, Ana Guerra-Librero, Darío Acuña-Castroviejo, María M Molina-Navarro, José M García-Verdugo, Ramy K A Sayed, Javier Florido, Juan D Luna, Luis Carlos López, Germaine Escames
Published 2017-01-01