Evidence of a Mild Mutator Phenotype in Cambodian Plasmodium falciparum Malaria Parasites.

by Andrew H Lee, David A Fidock
Published 2016-01-01

Malaria's missing number: calculating the human component of R0 by a within-host mechanistic model of Plasmodium falciparum infection and transmission.

by Geoffrey L Johnston, David L Smith, David A Fidock
Published 2013-04-01

Modeling within-host effects of drugs on Plasmodium falciparum transmission and prospects for malaria elimination.

by Geoffrey L Johnston, Peter W Gething, Simon I Hay, David L Smith, David A Fidock
Published 2014-01-01

Structure-Based Screening of Plasmodium berghei Glutathione S-Transferase Identifies CB-27 as a Novel Antiplasmodial Compound

by Emilee E. Colón-Lorenzo, Daisy D. Colón-López, Joel Vega-Rodríguez, Alice Dupin, David A. Fidock, David A. Fidock, Abel Baerga-Ortiz, José G. Ortiz, Jürgen Bosch, Jürgen Bosch, Jürgen Bosch, Adelfa E. Serrano
Published 2020-03-01

Identification of a mutant PfCRT-mediated chloroquine tolerance phenotype in Plasmodium falciparum.

by Stephanie G Valderramos, Juan-Carlos Valderramos, Lise Musset, Lisa A Purcell, Odile Mercereau-Puijalon, Eric Legrand, David A Fidock
Published 2010-05-01

Plasmodium falciparum K13 Mutations Differentially Impact Ozonide Susceptibility and Parasite Fitness In Vitro

by Judith Straimer, Nina F. Gnadig, Barbara H. Stokes, Michelle Ehrenberger, Audrey A. Crane, David A. Fidock, Louis H. Miller
Published 2017-04-01

Global Spread of Mutant PfCRT and Its Pleiotropic Impact on Plasmodium falciparum Multidrug Resistance and Fitness

by Satish K. Dhingra, Stanislaw J. Gabryszewski, Jennifer L. Small-Saunders, Tomas Yeo, Philipp P. Henrich, Sachel Mok, David A. Fidock
Published 2019-04-01

Oleic acid biosynthesis in Plasmodium falciparum: characterization of the stearoyl-CoA desaturase and investigation as a potential therapeutic target.

by Paul Gratraud, Enlli Huws, Brie Falkard, Sophie Adjalley, David A Fidock, Laurence Berry, William R Jacobs, Mark S Baird, Henri Vial, Laurent Kremer
Published 2009-09-01

Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies

by M. Isabel Veiga, Satish K. Dhingra, Philipp P. Henrich, Judith Straimer, Nina Gnädig, Anne-Catrin Uhlemann, Rowena E. Martin, Adele M. Lehane, David A. Fidock
Published 2016-05-01

Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine

by Leila S. Ross, Satish K. Dhingra, Sachel Mok, Tomas Yeo, Kathryn J. Wicht, Krittikorn Kümpornsin, Shannon Takala-Harrison, Benoit Witkowski, Rick M. Fairhurst, Frederic Ariey, Didier Menard, David A. Fidock
Published 2018-08-01

Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents.

by Barbara H Stokes, Euna Yoo, James M Murithi, Madeline R Luth, Pavel Afanasyev, Paula C A da Fonseca, Elizabeth A Winzeler, Caroline L Ng, Matthew Bogyo, David A Fidock
Published 2019-06-01

Genetic screens reveal a central role for heme metabolism in artemisinin susceptibility

by Clare R. Harding, Saima M. Sidik, Boryana Petrova, Nina F. Gnädig, John Okombo, Alice L. Herneisen, Kurt E. Ward, Benedikt M. Markus, Elizabeth A. Boydston, David A. Fidock, Sebastian Lourido
Published 2020-09-01

Artemisinin-resistant K13 mutations rewire Plasmodium falciparum’s intra-erythrocytic metabolic program to enhance survival

by Sachel Mok, Barbara H. Stokes, Nina F. Gnädig, Leila S. Ross, Tomas Yeo, Chanaki Amaratunga, Erik Allman, Lev Solyakov, Andrew R. Bottrill, Jaishree Tripathi, Rick M. Fairhurst, Manuel Llinás, Zbynek Bozdech, Andrew B. Tobin, David A. Fidock
Published 2021-01-01

Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13.

by Nina F Gnädig, Barbara H Stokes, Rachel L Edwards, Gavreel F Kalantarov, Kim C Heimsch, Michal Kuderjavy, Audrey Crane, Marcus C S Lee, Judith Straimer, Katja Becker, Ilya N Trakht, Audrey R Odom John, Sachel Mok, David A Fidock
Published 2020-04-01

Targeting the cell stress response of Plasmodium falciparum to overcome artemisinin resistance.

by Con Dogovski, Stanley C Xie, Gaetan Burgio, Jess Bridgford, Sachel Mok, James M McCaw, Kesinee Chotivanich, Shannon Kenny, Nina Gnädig, Judith Straimer, Zbynek Bozdech, David A Fidock, Julie A Simpson, Arjen M Dondorp, Simon Foote, Nectarios Klonis, Leann Tilley
Published 2015-04-01

Local emergence in Amazonia of Plasmodium falciparum k13 C580Y mutants associated with in vitro artemisinin resistance

by Luana C Mathieu, Horace Cox, Angela M Early, Sachel Mok, Yassamine Lazrek, Jeanne-Celeste Paquet, Maria-Paz Ade, Naomi W Lucchi, Quacy Grant, Venkatachalam Udhayakumar, Jean SF Alexandre, Magalie Demar, Pascal Ringwald, Daniel E Neafsey, David A Fidock, Lise Musset
Published 2020-05-01

Mitotic evolution of Plasmodium falciparum shows a stable core genome but recombination in antigen families.

by Selina E R Bopp, Micah J Manary, A Taylor Bright, Geoffrey L Johnston, Neekesh V Dharia, Fabio L Luna, Susan McCormack, David Plouffe, Case W McNamara, John R Walker, David A Fidock, Eros Lazzerini Denchi, Elizabeth A Winzeler
Published 2013-01-01

Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiol...

by Stanislaw J Gabryszewski, Satish K Dhingra, Jill M Combrinck, Ian A Lewis, Paul S Callaghan, Matthew R Hassett, Amila Siriwardana, Philipp P Henrich, Andrew H Lee, Nina F Gnädig, Lise Musset, Manuel Llinás, Timothy J Egan, Paul D Roepe, David A Fidock
Published 2016-11-01

Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages

by Evelien M. Bunnik, Kate B. Cook, Nelle Varoquaux, Gayani Batugedara, Jacques Prudhomme, Anthony Cort, Lirong Shi, Chiara Andolina, Leila S. Ross, Declan Brady, David A. Fidock, Francois Nosten, Rita Tewari, Photini Sinnis, Ferhat Ay, Jean-Philippe Vert, William Stafford Noble, Karine G. Le Roch
Published 2018-05-01

Generation of Transmission-Competent Human Malaria Parasites with Chromosomally-Integrated Fluorescent Reporters

by Kyle Jarrod McLean, Judith Straimer, Christine S. Hopp, Joel Vega-Rodriguez, Jennifer L. Small-Saunders, Sachie Kanatani, Abhai Tripathi, Godfree Mlambo, Peter C. Dumoulin, Chantal T. Harris, Xinran Tong, Melanie J. Shears, Johan Ankarklev, Björn F. C. Kafsack, David A. Fidock, Photini Sinnis
Published 2019-09-01