Dmitry Gabrilovich
Dmitry Gabrilovich is currently a Chief Scientist, Cancer Immunology at AstraZeneca in Gaithersburg, MD, USA. His research is focused on methods by which
tumors are able to suppress the immune system and how to develop new immune therapies to combat this ability. Gabrilovich described the defective ability of dendritic cells in induce immune responses in cancer, and was one of the discoverers of
myeloid-derived suppressor cells (MDSC). The Gabrilovich lab focuses on immature
myeloid cell biology and its relation to cancer. MDSC have been linked to a number of signaling pathways associated with cancer, including NF-κB, Jak-STAT, Notch, Wnt, and Rb, among others. His research has found that tumor cells can go through a mechanism that produces a free radical peroxynitrite, causing them to become resistant to certain types of cancer immunotherapy. His research has also focused on monocytic-myeloid derived suppressor cells and polymorphonuclear-myeloid derived suppressor cells and what impact they might have on cancer therapy, since myeloid derived suppressor cells negatively regulate anti-tumor activity. His group described methods of targeting suppressive myeloid cell.
In 2019 he was awarded title of Research Professor by American Cancer Society.
Prior to joining AstraZeneca, Gabrilovich was a researcher and Christopher M. Davis professor at
The Wistar Institute in
Philadelphia.
Prior to joining The Wistar Institute, Gabrilovich was a senior member at the
Moffitt Cancer Center in
Tampa.
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