Motor neurone disease and animal models

by Donald L. Price, Don W. Cleveland, Vassilis E. Koliatsos
Published 1994-11-01

Low Rates of Aneuploidy Promote Tumorigenesis while High Rates of Aneuploidy Cause Cell Death and Tumor Suppression

by Beth A. A. Weaver, Alain D. Silk, Don W. Cleveland
Published 2008-01-01

TRIP13 and APC15 drive mitotic exit by turnover of interphase- and unattached kinetochore-produced MCC

by Dong Hyun Kim, Joo Seok Han, Peter Ly, Qiaozhen Ye, Moira A. McMahon, Kyungjae Myung, Kevin D. Corbett, Don W. Cleveland
Published 2018-10-01

The SARS-CoV-2 nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein

by Shan Lu, Qiaozhen Ye, Digvijay Singh, Yong Cao, Jolene K. Diedrich, John R. Yates, Elizabeth Villa, Don W. Cleveland, Kevin D. Corbett
Published 2021-01-01

Chromosomal instability by inefficient Mps1 auto-activation due to a weakened mitotic checkpoint and lagging chromosomes.

by Nannette Jelluma, Arjan B Brenkman, Ian McLeod, John R Yates, Don W Cleveland, René H Medema, Geert J P L Kops
Published 2008-01-01

Human condensin function is essential for centromeric chromatin assembly and proper sister kinetochore orientation.

by Alexander Samoshkin, Alexei Arnaoutov, Lars E T Jansen, Ilia Ouspenski, Louis Dye, Tatiana Karpova, James McNally, Mary Dasso, Don W Cleveland, Alexander Strunnikov
Published 2009-08-01

Phosphorylation of CENP-A on serine 7 does not control centromere function

by Viviana Barra, Glennis A. Logsdon, Andrea Scelfo, Sebastian Hoffmann, Solène Hervé, Aaron Aslanian, Yael Nechemia-Arbely, Don W. Cleveland, Ben E. Black, Daniele Fachinetti
Published 2019-01-01

Mutations in neurofilament genes are not a significant primary cause of non-SOD1-mediated amyotrophic lateral sclerosis

by Michael L. Garcia, Andrew B. Singleton, Dena Hernandez, Christopher M. Ward, Crystal Evey, Peter A. Sapp, John Hardy, Robert H. Brown, Jr., Don W. Cleveland
Published 2006-01-01

Messenger RNA oxidation occurs early in disease pathogenesis and promotes motor neuron degeneration in ALS.

by Yueming Chang, Qiongman Kong, Xiu Shan, Guilian Tian, Hristelina Ilieva, Don W Cleveland, Jeffrey D Rothstein, David R Borchelt, Philip C Wong, Chien-Liang Glenn Lin
Published 2008-08-01

Human neural stem cell replacement therapy for amyotrophic lateral sclerosis by spinal transplantation.

by Michael P Hefferan, Jan Galik, Osamu Kakinohana, Gabriela Sekerkova, Camila Santucci, Silvia Marsala, Roman Navarro, Marian Hruska-Plochan, Karl Johe, Eva Feldman, Don W Cleveland, Martin Marsala
Published 2012-01-01

C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2α phosphorylation

by Weiwei Cheng, Shaopeng Wang, Alexander A. Mestre, Chenglai Fu, Andres Makarem, Fengfan Xian, Lindsey R. Hayes, Rodrigo Lopez-Gonzalez, Kevin Drenner, Jie Jiang, Don W. Cleveland, Shuying Sun
Published 2018-01-01

The quantitative architecture of centromeric chromatin

by Dani L Bodor, João F Mata, Mikhail Sergeev, Ana Filipa David, Kevan J Salimian, Tanya Panchenko, Don W Cleveland, Ben E Black, Jagesh V Shah, Lars ET Jansen
Published 2014-07-01

Misfolded SOD1 associated with motor neuron mitochondria alters mitochondrial shape and distribution prior to clinical onset.

by Christine Vande Velde, Karli K McDonald, Yasmin Boukhedimi, Melissa McAlonis-Downes, Christian S Lobsiger, Samar Bel Hadj, Andre Zandona, Jean-Pierre Julien, Sameer B Shah, Don W Cleveland
Published 2011-01-01

Novel STMN2 Variant Linked to Amyotrophic Lateral Sclerosis Risk and Clinical Phenotype

by Frances Theunissen, Frances Theunissen, Ryan S. Anderton, Ryan S. Anderton, Ryan S. Anderton, Frank L. Mastaglia, Frank L. Mastaglia, Loren L. Flynn, Loren L. Flynn, Loren L. Flynn, Samantha J. Winter, Samantha J. Winter, Ian James, Richard Bedlack, Stuart Hodgetts, Stuart Hodgetts, Sue Fletcher, Sue Fletcher, Steve D. Wilton, Steve D. Wilton, Steve D. Wilton, Nigel G. Laing, Mandi MacShane, Merrilee Needham, Merrilee Needham, Merrilee Needham, Ann Saunders, Alan Mackay-Sim, Alan Mackay-Sim, Ze’ev Melamed, Ze’ev Melamed, John Ravits, Don W. Cleveland, Don W. Cleveland, Don W. Cleveland, P. Anthony Akkari, P. Anthony Akkari, P. Anthony Akkari, P. Anthony Akkari
Published 2021-03-01

Centromeres are maintained by fastening CENP-A to DNA and directing an arginine anchor-dependent nucleosome transition

by Lucie Y. Guo, Praveen Kumar Allu, Levani Zandarashvili, Kara L. McKinley, Nikolina Sekulic, Jennine M. Dawicki-McKenna, Daniele Fachinetti, Glennis A. Logsdon, Ryan M. Jamiolkowski, Don W. Cleveland, Iain M. Cheeseman, Ben E. Black
Published 2017-06-01

Axonal Transport of Mutant Superoxide Dismutase 1 and Focal Axonal Abnormalities in the Proximal Axons of Transgenic Mice

by David R. Borchelt, Philip C. Wong, Mark W. Becher, Carlos A. Pardo, Michael K. Lee, Zuo-Shang Xu, Gopal Thinakaran, Nancy A. Jenkins, Neal G. Copeland, Sangram S. Sisodia, Don W. Cleveland, Donald L. Price, Paul N. Hoffman
Published 1998-07-01

Wild-type FUS corrects ALS-like disease induced by cytoplasmic mutant FUS through autoregulation

by Inmaculada Sanjuan-Ruiz, Noé Govea-Perez, Melissa McAlonis-Downes, Stéphane Dieterle, Salim Megat, Sylvie Dirrig-Grosch, Gina Picchiarelli, Diana Piol, Qiang Zhu, Brian Myers, Chao-Zong Lee, Don W Cleveland, Clotilde Lagier-Tourenne, Sandrine Da Cruz, Luc Dupuis
Published 2021-09-01

Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis

by Shuo-Chien Ling, Somasish Ghosh Dastidar, Seiya Tokunaga, Wan Yun Ho, Kenneth Lim, Hristelina Ilieva, Philippe A Parone, Sheue-Houy Tyan, Tsemay M Tse, Jer-Cherng Chang, Oleksandr Platoshyn, Ngoc B Bui, Anh Bui, Anne Vetto, Shuying Sun, Melissa McAlonis-Downes, Joo Seok Han, Debbie Swing, Katannya Kapeli, Gene W Yeo, Lino Tessarollo, Martin Marsala, Christopher E Shaw, Greg Tucker-Kellogg, Albert R La Spada, Clotilde Lagier-Tourenne, Sandrine Da Cruz, Don W Cleveland
Published 2019-02-01