Understanding HCMV Latency Using Unbiased Proteomic Analyses

by Emma Poole, John Sinclair
Published 2020-07-01

Depletion of cellular pre-replication complex factors results in increased human cytomegalovirus DNA replication.

by Tamara Evans Braun, Emma Poole, John Sinclair
Published 2012-01-01

The cellular protein MCM3AP is required for inhibition of cellular DNA synthesis by the IE86 protein of human cytomegalovirus.

by Emma Poole, Mark Bain, Linda Teague, Yoshinori Takei, Ron Laskey, John Sinclair
Published 2012-01-01

Human Cytomegalovirus Interleukin 10 Homologs: Facing the Immune System

by Emma Poole, Tainan Cerqueira Neves, Martha Trindade Oliveira, John Sinclair, Maria Cristina Carlan da Silva
Published 2020-06-01

Human cytomegalovirus latency-associated proteins elicit immune-suppressive IL-10 producing CD4⁺ T cells.

by Gavin M Mason, Sarah Jackson, Georgina Okecha, Emma Poole, J G Patrick Sissons, John Sinclair, Mark R Wills
Published 2013-01-01

Human Cytomegalovirus Upregulates Expression of HCLS1 Resulting in Increased Cell Motility and Transendothelial Migration during Latency

by Yusuf Aslam, James Williamson, Veronika Romashova, Elizabeth Elder, Benjamin Krishna, Mark Wills, Paul Lehner, John Sinclair, Emma Poole
Published 2019-10-01

Defining the Transcriptional Landscape during Cytomegalovirus Latency with Single-Cell RNA Sequencing

by Miri Shnayder, Aharon Nachshon, Benjamin Krishna, Emma Poole, Alina Boshkov, Amit Binyamin, Itay Maza, John Sinclair, Michal Schwartz, Noam Stern-Ginossar, Rozanne M. Sandri-Goldin
Published 2018-03-01

Interferon-Responsive Genes Are Targeted during the Establishment of Human Cytomegalovirus Latency

by Elizabeth G. Elder, Benjamin A. Krishna, James Williamson, Eleanor Y. Lim, Emma Poole, George X. Sedikides, Mark Wills, Christine M. O’Connor, Paul J. Lehner, John Sinclair
Published 2019-12-01

Monocytes Latently Infected with Human Cytomegalovirus Evade Neutrophil Killing

by Elizabeth Elder, Benjamin Krishna, James Williamson, Yusuf Aslam, Neda Farahi, Alexander Wood, Veronika Romashova, Kate Roche, Eain Murphy, Edwin Chilvers, Paul J. Lehner, John Sinclair, Emma Poole
Published 2019-02-01

Single cell analysis reveals human cytomegalovirus drives latently infected cells towards an anergic-like monocyte state

by Miri Shnayder, Aharon Nachshon, Batsheva Rozman, Biana Bernshtein, Michael Lavi, Noam Fein, Emma Poole, Selmir Avdic, Emily Blyth, David Gottlieb, Allison Abendroth, Barry Slobedman, John Sinclair, Noam Stern-Ginossar, Michal Schwartz
Published 2020-01-01

An iPSC-Derived Myeloid Lineage Model of Herpes Virus Latency and Reactivation

by Emma Poole, Christopher J. Z. Huang, Jessica Forbester, Miri Shnayder, Aharon Nachshon, Baraa Kweider, Anna Basaj, Daniel Smith, Sarah Elizabeth Jackson, Bin Liu, Joy Shih, Fedir N. Kiskin, K. Roche, E. Murphy, Mark R. Wills, Nicholas W. Morrell, Gordon Dougan, Gordon Dougan, Noam Stern-Ginossar, Amer A. Rana, John Sinclair
Published 2019-10-01