Response to mepolizumab treatment is sustained across 4-weekly dosing periods

by Ian D. Pavord, Eugene R. Bleecker, Roland Buhl, Pascal Chanez, Elisabeth H. Bel, Peter Howarth, Daniel J. Bratton, Frank C. Albers, Steven Yancey
Published 2020-09-01

Drug Repurposing to Treat Glucocorticoid Resistance in Asthma

by Alberta L. Wang, Ronald Panganiban, Weiliang Qiu, Alvin T. Kho, Geoffrey Chupp, Deborah A. Meyers, Eugene R. Bleecker, Scott T. Weiss, Quan Lu, Kelan G. Tantisira
Published 2021-03-01

Clinical Implications of Having Reduced Mid Forced Expiratory Flow Rates (FEF25-75), Independently of FEV1, in Adult Patients with Asthma.

by Craig M Riley, Sally E Wenzel, Mario Castro, Serpil C Erzurum, Kian Fan Chung, Anne M Fitzpatrick, Benjamin Gaston, Elliot Israel, Wendy C Moore, Eugene R Bleecker, William J Calhoun, Nizar N Jarjour, William W Busse, Stephen P Peters, W Gerald Teague, Ronald Sorkness, Fernando Holguin
Published 2015-01-01

Impact of Age and Sex on Outcomes and Hospital Cost of Acute Asthma in the United States, 2011-2012.

by Joe G Zein, Belinda L Udeh, W Gerald Teague, Siran M Koroukian, Nicholas K Schlitz, Eugene R Bleecker, William B Busse, William J Calhoun, Mario Castro, Suzy A Comhair, Anne M Fitzpatrick, Elliot Israel, Sally E Wenzel, Fernando Holguin, Benjamin M Gaston, Serpil C Erzurum, Severe Asthma Research Program
Published 2016-01-01

Asthma Is More Severe in Older Adults.

by Joe G Zein, Raed A Dweik, Suzy A Comhair, Eugene R Bleecker, Wendy C Moore, Stephen P Peters, William W Busse, Nizar N Jarjour, William J Calhoun, Mario Castro, K Fan Chung, Anne Fitzpatrick, Elliot Israel, W Gerald Teague, Sally E Wenzel, Thomas E Love, Benjamin M Gaston, Serpil C Erzurum, Severe Asthma Research Program
Published 2015-01-01

Genome-wide association study of lung function and clinical implication in heavy smokers

by Xingnan Li, Victor E. Ortega, Elizabeth J. Ampleford, R. Graham Barr, Stephanie A. Christenson, Christopher B. Cooper, David Couper, Mark T. Dransfield, Mei Lan K. Han, Nadia N. Hansel, Eric A. Hoffman, Richard E. Kanner, Eric C. Kleerup, Fernando J. Martinez, Robert Paine, Prescott G. Woodruff, Gregory A. Hawkins, Eugene R. Bleecker, Deborah A. Meyers, for the SPIROMICS Research Group
Published 2018-08-01

The influence of social support on COPD outcomes mediated by depression.

by Leonard Turnier, Michelle Eakin, Han Woo, Mark Dransfield, Trisha Parekh, Jerry A Krishnan, Richard Kanner, Christopher B Cooper, Prescott G Woodruff, Robert Wise, MeiLan K Han, Karina Romero, Laura M Paulin, Stephen Peters, Brad Drummond, Eugene R Bleecker, Russell Bowler, Alejandro P Comellas, David Couper, Robert Paine, Fernando Martinez, Graham Barr, Nirupama Putcha, Nadia N Hansel
Published 2021-01-01

Latent traits of lung tissue patterns in former smokers derived by dual channel deep learning in computed tomography images

by Frank Li, Jiwoong Choi, Chunrui Zou, John D. Newell, Alejandro P. Comellas, Chang Hyun Lee, Hongseok Ko, R. Graham Barr, Eugene R. Bleecker, Christopher B. Cooper, Fereidoun Abtin, Igor Barjaktarevic, David Couper, MeiLan Han, Nadia N. Hansel, Richard E. Kanner, Robert Paine, Ella A. Kazerooni, Fernando J. Martinez, Wanda O’Neal, Stephen I. Rennard, Benjamin M. Smith, Prescott G. Woodruff, Eric A. Hoffman, Ching-Long Lin
Published 2021-03-01

Detrimental effects of environmental tobacco smoke in relation to asthma severity.

by Suzy A A Comhair, Benjamin M Gaston, Kristin S Ricci, Jeffrey Hammel, Raed A Dweik, W Gerald Teague, Deborah Meyers, Elizabeth J Ampleford, Eugene R Bleecker, William W Busse, William J Calhoun, Mario Castro, Kian Fan Chung, Douglas Curran-Everett, Elliot Israel, W Nizar Jarjour, Wendy Moore, Stephen P Peters, Sally Wenzel, Stanley L Hazen, Serpil C Erzurum, National Heart Lung Blood Institute Severe Asthma Research Program
Published 2011-05-01

Heterogeneous burden of lung disease in smokers with borderline airflow obstruction

by Cheryl S. Pirozzi, Tian Gu, Pedro M. Quibrera, Elizabeth E. Carretta, MeiLan K. Han, Susan Murray, Christopher B. Cooper, Donald P. Tashkin, Eric C. Kleerup, Igor Barjaktarevic, Eric A. Hoffman, Carlos H. Martinez, Stephanie A. Christenson, Nadia N. Hansel, R. Graham Barr, Eugene R. Bleecker, Victor E. Ortega, Fernando J. Martinez, Richard E. Kanner, Robert Paine, for the NHLBI SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS)
Published 2018-11-01

Variability in objective and subjective measures affects baseline values in studies of patients with COPD.

by Wayne H Anderson, Jae Wook Ha, David J Couper, Wanda K O'Neal, R Graham Barr, Eugene R Bleecker, Elizabeth E Carretta, Christopher B Cooper, Claire M Doerschuk, M Bradley Drummond, MeiLan K Han, Nadia N Hansel, Victor Kim, Eric C Kleerup, Fernando J Martinez, Stephen I Rennard, Donald Tashkin, Prescott G Woodruff, Robert Paine, Jeffrey L Curtis, Richard E Kanner, SPIROMICS Research Group
Published 2017-01-01

Lung microbiota associations with clinical features of COPD in the SPIROMICS cohort

by Kristopher Opron, Lesa A. Begley, John R. Erb-Downward, Christine Freeman, Siddharth Madapoosi, Neil E. Alexis, Igor Barjaktarevic, R. Graham Barr, Eugene R. Bleecker, Russell P. Bowler, Stephanie A. Christenson, Alejandro P. Comellas, Christopher B. Cooper, David J. Couper, Claire M. Doerschuk, Mark T. Dransfield, MeiLan K. Han, Nadia N. Hansel, Annette T. Hastie, Eric A. Hoffman, Robert J. Kaner, Jerry Krishnan, Wanda K. O’Neal, Victor E. Ortega, Robert Paine, Stephen P. Peters, J. Michael Wells, Prescott G. Woodruff, Fernando J. Martinez, Jeffrey L. Curtis, Gary B. Huffnagle, Yvonne J. Huang
Published 2021-02-01

Genome-wide association analysis in asthma subjects identifies SPATS2L as a novel bronchodilator response gene.

by Blanca E Himes, Xiaofeng Jiang, Ruoxi Hu, Ann C Wu, Jessica A Lasky-Su, Barbara J Klanderman, John Ziniti, Jody Senter-Sylvia, John J Lima, Charles G Irvin, Stephen P Peters, Deborah A Meyers, Eugene R Bleecker, Michiaki Kubo, Mayumi Tamari, Yusuke Nakamura, Stanley J Szefler, Robert F Lemanske, Robert S Zeiger, Robert C Strunk, Fernando D Martinez, John P Hanrahan, Gerard H Koppelman, Dirkje S Postma, Maartje A E Nieuwenhuis, Judith M Vonk, Reynold A Panettieri, Amy Markezich, Elliot Israel, Vincent J Carey, Kelan G Tantisira, Augusto A Litonjua, Quan Lu, Scott T Weiss
Published 2012-07-01

Effects of endogenous sex hormones on lung function and symptom control in adolescents with asthma

by Mark D. DeBoer, Brenda R. Phillips, David T. Mauger, Joe Zein, Serpil C. Erzurum, Anne M. Fitzpatrick, Benjamin M. Gaston, Ross Myers, Kristie R. Ross, James Chmiel, Min Jie Lee, John V. Fahy, Michael Peters, Ngoc P. Ly, Sally E. Wenzel, Merritt L. Fajt, Fernando Holguin, Wendy C. Moore, Stephen P. Peters, Deborah Meyers, Eugene R. Bleecker, Mario Castro, Andrea M. Coverstone, Leonard B. Bacharier, Nizar N. Jarjour, Ronald L. Sorkness, Sima Ramratnam, Anne-Marie Irani, Elliot Israel, Bruce Levy, Wanda Phipatanakul, Jonathan M. Gaffin, W. Gerald Teague
Published 2018-04-01

Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD.

by Wei Sun, Katerina Kechris, Sean Jacobson, M Bradley Drummond, Gregory A Hawkins, Jenny Yang, Ting-Huei Chen, Pedro Miguel Quibrera, Wayne Anderson, R Graham Barr, Patricia V Basta, Eugene R Bleecker, Terri Beaty, Richard Casaburi, Peter Castaldi, Michael H Cho, Alejandro Comellas, James D Crapo, Gerard Criner, Dawn Demeo, Stephanie A Christenson, David J Couper, Jeffrey L Curtis, Claire M Doerschuk, Christine M Freeman, Natalia A Gouskova, MeiLan K Han, Nicola A Hanania, Nadia N Hansel, Craig P Hersh, Eric A Hoffman, Robert J Kaner, Richard E Kanner, Eric C Kleerup, Sharon Lutz, Fernando J Martinez, Deborah A Meyers, Stephen P Peters, Elizabeth A Regan, Stephen I Rennard, Mary Beth Scholand, Edwin K Silverman, Prescott G Woodruff, Wanda K O'Neal, Russell P Bowler, SPIROMICS Research Group, COPDGene Investigators
Published 2016-08-01

Genetic and non-genetic factors affecting the expression of COVID-19-relevant genes in the large airway epithelium

by Silva Kasela, Victor E. Ortega, Molly Martorella, Suresh Garudadri, Jenna Nguyen, Elizabeth Ampleford, Anu Pasanen, Srilaxmi Nerella, Kristina L. Buschur, Igor Z. Barjaktarevic, R. Graham Barr, Eugene R. Bleecker, Russell P. Bowler, Alejandro P. Comellas, Christopher B. Cooper, David J. Couper, Gerard J. Criner, Jeffrey L. Curtis, MeiLan K. Han, Nadia N. Hansel, Eric A. Hoffman, Robert J. Kaner, Jerry A. Krishnan, Fernando J. Martinez, Merry-Lynn N. McDonald, Deborah A. Meyers, Robert Paine, Stephen P. Peters, Mario Castro, Loren C. Denlinger, Serpil C. Erzurum, John V. Fahy, Elliot Israel, Nizar N. Jarjour, Bruce D. Levy, Xingnan Li, Wendy C. Moore, Sally E. Wenzel, Joe Zein, NHLBI SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS), NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Charles Langelier, Prescott G. Woodruff, Tuuli Lappalainen, Stephanie A. Christenson
Published 2021-04-01

Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene.

by Blanca E Himes, Keith Sheppard, Annerose Berndt, Adriana S Leme, Rachel A Myers, Christopher R Gignoux, Albert M Levin, W James Gauderman, James J Yang, Rasika A Mathias, Isabelle Romieu, Dara G Torgerson, Lindsey A Roth, Scott Huntsman, Celeste Eng, Barbara Klanderman, John Ziniti, Jody Senter-Sylvia, Stanley J Szefler, Robert F Lemanske, Robert S Zeiger, Robert C Strunk, Fernando D Martinez, Homer Boushey, Vernon M Chinchilli, Elliot Israel, David Mauger, Gerard H Koppelman, Dirkje S Postma, Maartje A E Nieuwenhuis, Judith M Vonk, John J Lima, Charles G Irvin, Stephen P Peters, Michiaki Kubo, Mayumi Tamari, Yusuke Nakamura, Augusto A Litonjua, Kelan G Tantisira, Benjamin A Raby, Eugene R Bleecker, Deborah A Meyers, Stephanie J London, Kathleen C Barnes, Frank D Gilliland, L Keoki Williams, Esteban G Burchard, Dan L Nicolae, Carole Ober, Dawn L DeMeo, Edwin K Silverman, Beverly Paigen, Gary Churchill, Steve D Shapiro, Scott T Weiss
Published 2013-01-01

Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease

by Jonas B. Nielsen, Oren Rom, Ida Surakka, Sarah E. Graham, Wei Zhou, Tanmoy Roychowdhury, Lars G. Fritsche, Sarah A. Gagliano Taliun, Carlo Sidore, Yuhao Liu, Maiken E. Gabrielsen, Anne Heidi Skogholt, Brooke Wolford, William Overton, Ying Zhao, Jin Chen, He Zhang, Whitney E. Hornsby, Akua Acheampong, Austen Grooms, Amanda Schaefer, Gregory J. M. Zajac, Luis Villacorta, Jifeng Zhang, Ben Brumpton, Mari Løset, Vivek Rai, Pia R. Lundegaard, Morten S. Olesen, Kent D. Taylor, Nicholette D. Palmer, Yii-Der Chen, Seung H. Choi, Steven A. Lubitz, Patrick T. Ellinor, Kathleen C. Barnes, Michelle Daya, Nicholas Rafaels, Scott T. Weiss, Jessica Lasky-Su, Russell P. Tracy, Ramachandran S. Vasan, L. Adrienne Cupples, Rasika A. Mathias, Lisa R. Yanek, Lewis C. Becker, Patricia A. Peyser, Lawrence F. Bielak, Jennifer A. Smith, Stella Aslibekyan, Bertha A. Hidalgo, Donna K. Arnett, Marguerite R. Irvin, James G. Wilson, Solomon K. Musani, Adolfo Correa, Stephen S. Rich, Xiuqing Guo, Jerome I. Rotter, Barbara A. Konkle, Jill M. Johnsen, Allison E. Ashley-Koch, Marilyn J. Telen, Vivien A. Sheehan, John Blangero, Joanne E. Curran, Juan M. Peralta, Courtney Montgomery, Wayne H-H Sheu, Ren-Hua Chung, Karen Schwander, Seyed M. Nouraie, Victor R. Gordeuk, Yingze Zhang, Charles Kooperberg, Alexander P. Reiner, Rebecca D. Jackson, Eugene R. Bleecker, Deborah A. Meyers, Xingnan Li, Sayantan Das, Ketian Yu, Jonathon LeFaive, Albert Smith, Tom Blackwell, Daniel Taliun, Sebastian Zollner, Lukas Forer, Sebastian Schoenherr, Christian Fuchsberger, Anita Pandit, Matthew Zawistowski, Sachin Kheterpal, Chad M. Brummett, Pradeep Natarajan, David Schlessinger, Seunggeun Lee, Hyun Min Kang, Francesco Cucca, Oddgeir L. Holmen, Bjørn O. Åsvold, Michael Boehnke, Sekar Kathiresan, Goncalo R. Abecasis, Y. Eugene Chen, Cristen J. Willer, Kristian Hveem
Published 2020-12-01