What makes a protein sequence a prion?

by Raimon Sabate, Frederic Rousseau, Joost Schymkowitz, Salvador Ventura
Published 2015-01-01

Increased Aggregation Is More Frequently Associated to Human Disease-Associated Mutations Than to Neutral Polymorphisms.

by Greet De Baets, Loic Van Doorn, Frederic Rousseau, Joost Schymkowitz
Published 2015-09-01

Structure-based machine-guided mapping of amyloid sequence space reveals uncharted sequence clusters with higher solubilities

by Nikolaos Louros, Gabriele Orlando, Matthias De Vleeschouwer, Frederic Rousseau, Joost Schymkowitz
Published 2020-07-01

Bacterial Protein Homeostasis Disruption as a Therapeutic Intervention

by Laleh Khodaparast, Laleh Khodaparast, Guiqin Wu, Guiqin Wu, Ladan Khodaparast, Ladan Khodaparast, Béla Z. Schmidt, Béla Z. Schmidt, Frederic Rousseau, Frederic Rousseau, Joost Schymkowitz, Joost Schymkowitz
Published 2021-06-01

Targeting S100B with Peptides Encoding Intrinsic Aggregation-Prone Sequence Segments

by Joana S. Cristóvão, Mariana A. Romão, Rodrigo Gallardo, Joost Schymkowitz, Frederic Rousseau, Cláudio M. Gomes
Published 2021-01-01

An evolutionary trade-off between protein turnover rate and protein aggregation favors a higher aggregation propensity in fast degrading proteins.

by Greet De Baets, Joke Reumers, Javier Delgado Blanco, Joaquin Dopazo, Joost Schymkowitz, Frederic Rousseau
Published 2011-06-01

Accurate prediction of DnaK-peptide binding via homology modelling and experimental data.

by Joost Van Durme, Sebastian Maurer-Stroh, Rodrigo Gallardo, Hannah Wilkinson, Frederic Rousseau, Joost Schymkowitz
Published 2009-08-01

Reconstruction of protein backbones from the BriX collection of canonical protein fragments.

by Lies Baeten, Joke Reumers, Vicente Tur, François Stricher, Tom Lenaerts, Luis Serrano, Frederic Rousseau, Joost Schymkowitz
Published 2008-05-01

Genome-wide prediction of SH2 domain targets using structural information and the FoldX algorithm.

by Ignacio E Sánchez, Pedro Beltrao, Francois Stricher, Joost Schymkowitz, Jesper Ferkinghoff-Borg, Frederic Rousseau, Luis Serrano
Published 2008-04-01

Entropic Bristles Tune the Seeding Efficiency of Prion-Nucleating Fragments

by Emiel Michiels, Shu Liu, Rodrigo Gallardo, Nikolaos Louros, Marion Mathelié-Guinlet, Yves Dufrêne, Joost Schymkowitz, Ina Vorberg, Frederic Rousseau
Published 2020-02-01

From Binding-Induced Dynamic Effects in SH3 Structures to Evolutionary Conserved Sectors.

by Ana Zafra Ruano, Elisa Cilia, José R Couceiro, Javier Ruiz Sanz, Joost Schymkowitz, Frederic Rousseau, Irene Luque, Tom Lenaerts
Published 2016-05-01

Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling

by Antonio Luis Egea-Jimenez, Rodrigo Gallardo, Abel Garcia-Pino, Ylva Ivarsson, Anna Maria Wawrzyniak, Rudra Kashyap, Remy Loris, Joost Schymkowitz, Frederic Rousseau, Pascale Zimmermann
Published 2016-07-01

MAPRE2 mutations result in altered human cranial neural crest migration, underlying craniofacial malformations in CSC-KT syndrome

by Cedric Thues, Jorge S. Valadas, Liesbeth Deaulmerie, Ann Geens, Amit K. Chouhan, Ramon Duran-Romaña, Joost Schymkowitz, Frederic Rousseau, Michaela Bartusel, Rizwan Rehimi, Alvaro Rada-Iglesias, Patrik Verstreken, Hilde Van Esch
Published 2021-03-01

Liquid–Liquid Phase Separation Enhances TDP-43 LCD Aggregation but Delays Seeded Aggregation

by Donya Pakravan, Emiel Michiels, Anna Bratek-Skicki, Mathias De Decker, Joris Van Lindt, David Alsteens, Sylvie Derclaye, Philip Van Damme, Joost Schymkowitz, Frederic Rousseau, Peter Tompa, Ludo Van Den Bosch
Published 2021-04-01

Comprehensive subcellular topologies of polypeptides in Streptomyces

by Konstantinos C. Tsolis, Evridiki-Pandora Tsare, Georgia Orfanoudaki, Tobias Busche, Katerina Kanaki, Reshmi Ramakrishnan, Frederic Rousseau, Joost Schymkowitz, Christian Rückert, Jörn Kalinowski, Jozef Anné, Spyridoula Karamanou, Maria I. Klapa, Anastassios Economou
Published 2018-03-01

Structural hot spots for the solubility of globular proteins

by Ashok Ganesan, Aleksandra Siekierska, Jacinte Beerten, Marijke Brams, Joost Van Durme, Greet De Baets, Rob Van der Kant, Rodrigo Gallardo, Meine Ramakers, Tobias Langenberg, Hannah Wilkinson, Frederik De Smet, Chris Ulens, Frederic Rousseau, Joost Schymkowitz
Published 2016-02-01

Molecular Dissection of FUS Points at Synergistic Effect of Low-Complexity Domains in Toxicity

by Elke Bogaert, Steven Boeynaems, Masato Kato, Lin Guo, Thomas R. Caulfield, Jolien Steyaert, Wendy Scheveneels, Nathalie Wilmans, Wanda Haeck, Nicole Hersmus, Joost Schymkowitz, Frederic Rousseau, James Shorter, Patrick Callaerts, Wim Robberecht, Philip Van Damme, Ludo Van Den Bosch
Published 2018-07-01

Structural Basis of the Subcellular Topology Landscape of Escherichia coli

by Maria S. Loos, Reshmi Ramakrishnan, Reshmi Ramakrishnan, Wim Vranken, Wim Vranken, Alexandra Tsirigotaki, Evrydiki-Pandora Tsare, Valentina Zorzini, Jozefien De Geyter, Biao Yuan, Ioannis Tsamardinos, Ioannis Tsamardinos, Maria Klappa, Joost Schymkowitz, Frederic Rousseau, Spyridoula Karamanou, Anastassios Economou, Anastassios Economou
Published 2019-07-01

Aggregating sequences that occur in many proteins constitute weak spots of bacterial proteostasis

by Ladan Khodaparast, Laleh Khodaparast, Rodrigo Gallardo, Nikolaos N. Louros, Emiel Michiels, Reshmi Ramakrishnan, Meine Ramakers, Filip Claes, Lydia Young, Mohammad Shahrooei, Hannah Wilkinson, Matyas Desager, Wubishet Mengistu Tadesse, K. Peter R. Nilsson, Per Hammarström, Abram Aertsen, Sebastien Carpentier, Johan Van Eldere, Frederic Rousseau, Joost Schymkowitz
Published 2018-02-01

Reverse engineering synthetic antiviral amyloids

by Emiel Michiels, Kenny Roose, Rodrigo Gallardo, Ladan Khodaparast, Laleh Khodaparast, Rob van der Kant, Maxime Siemons, Bert Houben, Meine Ramakers, Hannah Wilkinson, Patricia Guerreiro, Nikolaos Louros, Suzanne J. F. Kaptein, Lorena Itatí Ibañez, Anouk Smet, Pieter Baatsen, Shu Liu, Ina Vorberg, Guy Bormans, Johan Neyts, Xavier Saelens, Frederic Rousseau, Joost Schymkowitz
Published 2020-06-01