Metabolic variation during development in culture of Leishmania donovani promastigotes.

by Ana Marta Silva, Anabela Cordeiro-da-Silva, Graham H Coombs
Published 2011-12-01

ATG5 is essential for ATG8-dependent autophagy and mitochondrial homeostasis in Leishmania major.

by Roderick A M Williams, Terry K Smith, Benjamin Cull, Jeremy C Mottram, Graham H Coombs
Published 2012-01-01

Identification of semicarbazones, thiosemicarbazones and triazine nitriles as inhibitors of Leishmania mexicana cysteine protease CPB.

by Jörg Schröder, Sandra Noack, Richard J Marhöfer, Jeremy C Mottram, Graham H Coombs, Paul M Selzer
Published 2013-01-01

Metabolomic profiling and stable isotope labelling of Trichomonas vaginalis and Tritrichomonas foetus reveal major differences in amino acid metabolism including the production of...

by Gareth D Westrop, Lijie Wang, Gavin J Blackburn, Tong Zhang, Liang Zheng, David G Watson, Graham H Coombs
Published 2017-01-01

Phosphoenolpyruvate carboxylase identified as a key enzyme in erythrocytic Plasmodium falciparum carbon metabolism.

by Janet Storm, Sonal Sethia, Gavin J Blackburn, Achuthanunni Chokkathukalam, David G Watson, Rainer Breitling, Graham H Coombs, Sylke Müller
Published 2014-01-01

Molecular mechanisms of drug resistance in natural Leishmania populations vary with genetic background.

by Saskia Decuypere, Manu Vanaerschot, Kirstyn Brunker, Hideo Imamura, Sylke Müller, Basudha Khanal, Suman Rijal, Jean-Claude Dujardin, Graham H Coombs
Published 2012-01-01

Metabolomic Analyses of Leishmania Reveal Multiple Species Differences and Large Differences in Amino Acid Metabolism.

by Gareth D Westrop, Roderick A M Williams, Lijie Wang, Tong Zhang, David G Watson, Ana Marta Silva, Graham H Coombs
Published 2015-01-01

Metabolomics to unveil and understand phenotypic diversity between pathogen populations.

by Ruben t'Kindt, Richard A Scheltema, Andris Jankevics, Kirstyn Brunker, Suman Rijal, Jean-Claude Dujardin, Rainer Breitling, David G Watson, Graham H Coombs, Saskia Decuypere
Published 2010-01-01

Heparin modulates the endopeptidase activity of Leishmania mexicana cysteine protease cathepsin L-Like rCPB2.8.

by Wagner A S Judice, Marcella A Manfredi, Gerson P Souza, Thiago M Sansevero, Paulo C Almeida, Cláudio S Shida, Tarsis F Gesteira, Luiz Juliano, Gareth D Westrop, Sanya J Sanderson, Graham H Coombs, Ivarne L S Tersariol
Published 2013-01-01