Stochastic Model of the Adaptive Immune Response Predicts Disease Severity and Captures Enhanced Cross-Reactivity in Natural Dengue Infections

by Hung D. Nguyen, Hung D. Nguyen, Sidhartha Chaudhury, Adam T. Waickman, Heather Friberg, Jeffrey R. Currier, Anders Wallqvist
Published 2021-08-01

Persistent COVID-19 Symptoms Minimally Impact the Development of SARS-CoV-2-Specific T Cell Immunity

by Hengsheng Fang, Adam D. Wegman, Kianna Ripich, Heather Friberg, Jeffrey R. Currier, Stephen J. Thomas, Timothy P. Endy, Adam T. Waickman
Published 2021-05-01

Assessing the Diversity and Stability of Cellular Immunity Generated in Response to the Candidate Live-Attenuated Dengue Virus Vaccine TAK-003

by Adam T. Waickman, Heather Friberg, Morgan Gargulak, Amanda Kong, Mark Polhemus, Timothy Endy, Stephen J. Thomas, Richard G. Jarman, Jeffrey R. Currier
Published 2019-07-01

Dissecting the heterogeneity of DENV vaccine-elicited cellular immunity using single-cell RNA sequencing and metabolic profiling

by Adam T. Waickman, Kaitlin Victor, Tao Li, Kristin Hatch, Wiriya Rutvisuttinunt, Carey Medin, Benjamin Gabriel, Richard G. Jarman, Heather Friberg, Jeffrey R. Currier
Published 2019-08-01

HIV-1 envelope resistance to proteasomal cleavage: implications for vaccine induced immune responses.

by Nicholas J Steers, Silvia Ratto-Kim, Mark S de Souza, Jeffrey R Currier, Jerome H Kim, Nelson L Michael, Carl R Alving, Mangala Rao
Published 2012-01-01

Longitudinal Analysis of Dengue Virus–Specific Memory T Cell Responses and Their Association With Clinical Outcome in Subsequent DENV Infection

by Luis Alberto Sanchez-Vargas, Kathryn B. Anderson, Anon Srikiatkhachorn, Anon Srikiatkhachorn, Jeffrey R. Currier, Heather Friberg, Timothy P. Endy, Stefan Fernandez, Anuja Mathew, Alan L. Rothman
Published 2021-07-01

Longitudinal Analysis of Memory B and T Cell Responses to Dengue Virus in a 5-Year Prospective Cohort Study in Thailand

by Luis A. Sánchez-Vargas, Sonia Kounlavouth, Madison L. Smith, Kathryn B. Anderson, Anon Srikiatkhachorn, Damon W. Ellison, Jeffrey R. Currier, Timothy P. Endy, Anuja Mathew, Alan L. Rothman
Published 2019-06-01

Protective versus pathologic pre-exposure cytokine profiles in dengue virus infection.

by Heather Friberg, Coreen M Beaumier, Sangshin Park, Pamela Pazoles, Timothy P Endy, Anuja Mathew, Jeffrey R Currier, Richard G Jarman, Kathryn B Anderson, Steven Hatch, Stephen J Thomas, Alan L Rothman
Published 2018-12-01

Transcriptomic signatures of NK cells suggest impaired responsiveness in HIV-1 infection and increased activity post-vaccination

by Margaret C. Costanzo, Dohoon Kim, Matthew Creegan, Kerri G. Lal, Julie A. Ake, Jeffrey R. Currier, Hendrik Streeck, Merlin L. Robb, Nelson L. Michael, Diane L. Bolton, Nicholas J. Steers, Michael A. Eller
Published 2018-03-01

Cell-Mediated Immunity Generated in Response to a Purified Inactivated Vaccine for Dengue Virus Type 1

by Heather Friberg, Luis J. Martinez, Leyi Lin, Jason M. Blaylock, Rafael A. De La Barrera, Alan L. Rothman, J. Robert Putnak, Kenneth H. Eckels, Stephen J. Thomas, Richard G. Jarman, Jeffrey R. Currier
Published 2020-01-01

A double-blind randomized phase I clinical trial targeting ALVAC-HIV vaccine to human dendritic cells.

by Michael A Eller, Bonnie M Slike, Josephine H Cox, Emil Lesho, Zhining Wang, Jeffrey R Currier, Janice M Darden, Victoria R Polonis, Maryanne T Vahey, Sheila Peel, Merlin L Robb, Nelson L Michael, Mary A Marovich
Published 2011-01-01

Temporally integrated single cell RNA sequencing analysis of PBMC from experimental and natural primary human DENV-1 infections.

by Adam T Waickman, Heather Friberg, Gregory D Gromowski, Wiriya Rutvisuttinunt, Tao Li, Hayden Siegfried, Kaitlin Victor, Michael K McCracken, Stefan Fernandez, Anon Srikiatkhachorn, Damon Ellison, Richard G Jarman, Stephen J Thomas, Alan L Rothman, Timothy Endy, Jeffrey R Currier
Published 2021-01-01

Heterologous prime-boost regimens using rAd35 and rMVA vectors elicit stronger cellular immune responses to HIV proteins than homologous regimens.

by Silvia Ratto-Kim, Jeffrey R Currier, Josephine H Cox, Jean-Louis Excler, Anais Valencia-Micolta, Doris Thelian, Vicky Lo, Eddy Sayeed, Victoria R Polonis, Patricia L Earl, Bernard Moss, Merlin L Robb, Nelson L Michael, Jerome H Kim, Mary A Marovich
Published 2012-01-01

Phase I safety and immunogenicity evaluation of MVA-CMDR, a multigenic, recombinant modified vaccinia Ankara-HIV-1 vaccine candidate.

by Jeffrey R Currier, Viseth Ngauy, Mark S de Souza, Silvia Ratto-Kim, Josephine H Cox, Victoria R Polonis, Patricia Earl, Bernard Moss, Sheila Peel, Bonnie Slike, Somchai Sriplienchan, Prasert Thongcharoen, Robert M Paris, Merlin L Robb, Jerome Kim, Nelson L Michael, Mary A Marovich
Published 2010-11-01

High-throughput high-resolution class I HLA genotyping in East Africa.

by Rebecca N Koehler, Anne M Walsh, Eric E Sanders-Buell, Leigh Anne Eller, Michael Eller, Jeffrey R Currier, Christian T Bautista, Fred Wabwire-Mangen, Michael Hoelscher, Leonard Maboko, Jerome Kim, Nelson L Michael, Merlin L Robb, Francine E McCutchan, Gustavo H Kijak
Published 2010-01-01

Identification of immunodominant CD4-restricted epitopes co-located with antibody binding sites in individuals vaccinated with ALVAC-HIV and AIDSVAX B/E.

by Silvia Ratto-Kim, Mark S de Souza, Jeffrey R Currier, Nicos Karasavvas, John Sidney, Morgane Rolland, Anais Valencia-Micolta, Sirinan Madnote, Alessandro Sette, Sorachai Nitayaphan, Punnee Pitisuttuthum, Jaranit Kaewkungwal, Supachai Rerks-Ngarm, Robert O'Connell, Nelson Michael, Merlin L Robb, Mary Marovich, Jerome H Kim
Published 2015-01-01

Enhanced dengue vaccine virus replication and neutralizing antibody responses in immune primed rhesus macaques

by Michael K. McCracken, Caitlin H. Kuklis, Chandrika B. Kannadka, David A. Barvir, Mark A. Sanborn, Adam T. Waickman, Hayden C. Siegfried, Kaitlin A. Victor, Kristin L. Hatch, Rafael De La Barrera, Shannon D. Walls, Wiriya Rutvisuttinunt, Jeffrey R. Currier, Heather Friberg, Richard G. Jarman, Gregory D. Gromowski
Published 2021-05-01

Route of inoculation and mosquito vector exposure modulate dengue virus replication kinetics and immune responses in rhesus macaques.

by Michael K McCracken, Gregory D Gromowski, Lindsey S Garver, Brad A Goupil, Kathryne D Walker, Heather Friberg, Jeffrey R Currier, Wiriya Rutvisuttinunt, Kevin L Hinton, Rebecca C Christofferson, Christopher N Mores, Yannick Vanloubbeeck, Clarisse Lorin, Marie-Pierre Malice, Stephen J Thomas, Richard G Jarman, David W Vaughn, J Robert Putnak, Lucile Warter
Published 2020-04-01

Innate and adaptive immune responses both contribute to pathological CD4 T cell activation in HIV-1 infected Ugandans.

by Michael A Eller, Kim G Blom, Veronica D Gonzalez, Leigh Anne Eller, Prossy Naluyima, Oliver Laeyendecker, Thomas C Quinn, Noah Kiwanuka, David Serwadda, Nelson K Sewankambo, Boonrat Tasseneetrithep, Maria J Wawer, Ronald H Gray, Mary A Marovich, Nelson L Michael, Mark S de Souza, Fred Wabwire-Mangen, Merlin L Robb, Jeffrey R Currier, Johan K Sandberg
Published 2011-04-01

Impact of prior flavivirus immunity on Zika virus infection in rhesus macaques.

by Michael K McCracken, Gregory D Gromowski, Heather L Friberg, Xiaoxu Lin, Peter Abbink, Rafael De La Barrera, Kenneth H Eckles, Lindsey S Garver, Michael Boyd, David Jetton, Dan H Barouch, Matthew C Wise, Bridget S Lewis, Jeffrey R Currier, Kayvon Modjarrad, Mark Milazzo, Michelle Liu, Anna B Mullins, J Robert Putnak, Nelson L Michael, Richard G Jarman, Stephen J Thomas
Published 2017-08-01