Super-enhancers: critical roles and therapeutic targets in hematologic malignancies

by Yunlu Jia, Wee-Joo Chng, Jianbiao Zhou
Published 2019-07-01

X‐linked inhibitor of apoptosis inhibition sensitizes acute myeloid leukemia cell response to TRAIL and chemotherapy through potentiated induction of proapoptotic machinery

by Jianbiao Zhou, Xiao Lu, Tuan Zea Tan, Wee‐Joo Chng
Published 2018-01-01

BET Bromodomain inhibition promotes De-repression of TXNIP and activation of ASK1-MAPK pathway in acute myeloid leukemia

by Yafeng Zhou, Jianbiao Zhou, Xiao Lu, Tuan-Zea Tan, Wee-Joo Chng
Published 2018-07-01

The slow-releasing hydrogen sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivo.

by Zheng Wei Lee, Jianbiao Zhou, Chien-Shing Chen, Yujun Zhao, Choon-Hong Tan, Ling Li, Philip Keith Moore, Lih-Wen Deng
Published 2011-01-01

Determinants of sensitivity to DZNep induced apoptosis in multiple myeloma cells.

by Zhigang Xie, Chonglei Bi, Lip Lee Cheong, Shaw Cheng Liu, Gaofeng Huang, Jianbiao Zhou, Qiang Yu, Chien-Shing Chen, Wee Joo Chng
Published 2011-01-01

A loss-of-function genetic screening reveals synergistic targeting of AKT/mTOR and WTN/β-catenin pathways for treatment of AML with high PRL-3 phosphatase

by Jianbiao Zhou, Sabrina Hui-Min Toh, Zit-Liang Chan, Jessie Yiying Quah, Jing-Yuan Chooi, Tuan Zea Tan, Phyllis S. Y. Chong, Qi Zeng, Wee-Joo Chng
Published 2018-03-01

Inhibition of LIN28B impairs leukemia cell growth and metabolism in acute myeloid leukemia

by Jianbiao Zhou, Chonglei Bi, Ying Qing Ching, Jing-Yuan Chooi, Xiao Lu, Jessie Yiying Quah, Sabrina Hui-Min Toh, Zit-Liang Chan, Tuan Zea Tan, Phyllis SY Chong, Wee-Joo Chng
Published 2017-07-01

Functional Characterization of D9, a Novel Deazaneplanocin A (DZNep) Analog, in Targeting Acute Myeloid Leukemia (AML).

by Xia Jiang, Cheryl Zi Hui Lim, Zhimei Li, Puay Leng Lee, Siti Maryam J M Yatim, Peiyong Guan, Juntao Li, Jianbiao Zhou, Jingxuan Pan, Wee-Joo Chng, Christina L L Chai, Qiang Yu
Published 2015-01-01

PRL-3, a metastasis associated tyrosine phosphatase, is involved in FLT3-ITD signaling and implicated in anti-AML therapy.

by Jianbiao Zhou, Chonglei Bi, Wee-Joo Chng, Lip-Lee Cheong, Shaw-Cheng Liu, Sylvia Mahara, Kian-Ghee Tay, Qi Zeng, Jie Li, Ke Guo, Cheng Peow Bobby Tan, Hanry Yu, Daniel H Albert, Chien-Shing Chen
Published 2011-01-01

Myeloma-specific superenhancers affect genes of biological and clinical relevance in myeloma

by Yunlu Jia, Jianbiao Zhou, Tze King Tan, Tae-Hoon Chung, Regina Wan Ju Wong, Jing-Yuan Chooi, Julia Sze Lynn Lim, Takaomi Sanda, Melissa Ooi, Sanjay De Mel, Cinnie Soekojo, Yongxia Chen, Enfan Zhang, Zhen Cai, Peng Shen, Jian Ruan, Wee-Joo Chng
Published 2021-02-01

PRL3-zumab as an immunotherapy to inhibit tumors expressing PRL3 oncoprotein

by Min Thura, Abdul Qader Al-Aidaroos, Abhishek Gupta, Cheng Ean Chee, Soo Chin Lee, Kam Man Hui, Jie Li, Yeoh Khay Guan, Wei Peng Yong, Jimmy So, Wee Joo Chng, Chin Hin Ng, Jianbiao Zhou, Ling Zhi Wang, John Shyi Peng Yuen, Henry Sun Sien Ho, Sim Mei Yi, Edmund Chiong, Su Pin Choo, Joanne Ngeow, Matthew Chau Hsien Ng, Clarinda Chua, Eugene Shen Ann Yeo, Iain Bee Huat Tan, Joel Xuan En Sng, Nicholas Yan Zhi Tan, Jean Paul Thiery, Boon Cher Goh, Qi Zeng
Published 2019-06-01