Harnessing the Anti-Nociceptive Potential of NK2 and NK3 Ligands in the Design of New Multifunctional μ/δ-Opioid Agonist–Neurokinin Antagonist Peptidomimetics

by Charlène Gadais, Justyna Piekielna-Ciesielska, Jolien De Neve, Charlotte Martin, Anna Janecka, Steven Ballet
Published 2021-09-01

Design, Synthesis and Functional Analysis of Cyclic Opioid Peptides with Dmt-Tic Pharmacophore

by Arijit Sarkar, Anna Adamska-Bartlomiejczyk, Justyna Piekielna-Ciesielska, Karol Wtorek, Alicja Kluczyk, Attila Borics, Anna Janecka
Published 2020-09-01

Antinociceptive potency of a fluorinated cyclopeptide Dmt-c[D-Lys-Phe-p-CF3-Phe-Asp]NH2

by Justyna Piekielna-Ciesielska, Adriano Mollica, Stefano Pieretti, Jakub Fichna, Agata Szymaszkiewicz, Marta Zielińska, Radzisław Kordek, Anna Janecka
Published 2018-01-01

Pharmacological Characterization of µ-Opioid Receptor Agonists with Biased G Protein or β-Arrestin Signaling, and Computational Study of Conformational Changes during Receptor Acti...

by Justyna Piekielna-Ciesielska, Roberto Artali, Ammar A.H. Azzam, David G. Lambert, Alicja Kluczyk, Luca Gentilucci, Anna Janecka
Published 2021-12-01