OTULIN deficiency in ORAS causes cell type‐specific LUBAC degradation, dysregulated TNF signalling and cell death

by Rune Busk Damgaard, Paul R Elliott, Kirby N Swatek, Eamonn R Maher, Polina Stepensky, Orly Elpeleg, David Komander, Yackov Berkun
Published 2019-03-01

Dissecting distinct proteolytic activities of FMDV Lpro implicates cleavage and degradation of RLR signaling proteins, not its deISGylase/DUB activity, in type I interferon suppres...

by Linda J Visser, Chiara Aloise, Kirby N Swatek, Gisselle N Medina, Karin M Olek, Huib H Rabouw, Raoul J de Groot, Martijn A Langereis, Teresa de Los Santos, David Komander, Tim Skern, Frank J M van Kuppeveld
Published 2020-07-01