Orthogonal gene knockout and activation with a catalytically active Cas9 nuclease

by Joung, Julia, Zhang, Feng, Konermann, Silvana, Dahlman, James E., Abudayyeh, Omar Osama, Gootenberg, Jonathan S.
Published 2016

Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA

by Nishimasu, Hiroshi, Dohmae, Naoshi, Ishitani, Ryuichiro, Nureki, Osamu, Ran, Fei, Hsu, Patrick, Konermann, Silvana M, Shehata, Soraya I., Zhang, Feng
Published 2017

Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA

by Nishimasu, Hiroshi, Dohmae, Naoshi, Ishitani, Ryuichiro, Nureki, Osamu, Ran, Fei, Hsu, Patrick, Konermann, Silvana M, Shehata, Soraya I., Zhang, Feng
Published 2017

Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening

by Joung, Julia, Konermann, Silvana M, Gootenberg, Jonathan S, Abudayyeh, Omar Osama, Platt, Randall Jeffrey, Brigham, Mark D, Sanjana, Neville E, Zhang, Feng
Published 2017

Optical control of mammalian endogenous transcription and epigenetic states

by Church, George M., Konermann, Silvana M, Brigham, Mark D, Trevino, Alexandro E., Hsu, Patrick, Heidenreich, Matthias, Cong, Le, Platt, Randall Jeffrey, Scott, David Arthur, Zhang, Feng
Published 2017

Optical control of mammalian endogenous transcription and epigenetic states

by Konermann, Silvana M., Brigham, Mark D., Trevino, Alexandro E., Hsu, Patrick, Heidenreich, Matthias, Cong, Le, Platt, Randall Jeffrey, Scott, David Arthur, Church, George M., Zhang, Feng
Published 2016

Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems

by Shmakov, Sergey, Makarova, Kira S, Wolf, Yuri I, Semenova, Ekaterina, Minakhin, Leonid, Severinov, Konstantin, Koonin, Eugene V, Abudayyeh, Omar Osama, Gootenberg, Jonathan S, Joung, Julia, Konermann, Silvana M, Zhang, Feng
Published 2017

Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

by Konermann, Silvana, Brigham, Mark D., Trevino, Alexandro E., Joung, Julia, Barcena, Clea, Hsu, Patrick D., Habib, Naomi, Gootenberg, Jonathan S., Nishimasu, Hiroshi, Nureki, Osamu, Zhang, Feng, Abudayyeh, Omar Osama
Published 2016

CloneSifter: enrichment of rare clones from heterogeneous cell populations

by Feldman, David, Tsai, FuNien, Garrity, Anthony J, O'Rourke, Ryan, Brenan, Lisa, Ho, Patricia, Gonzalez, Elizabeth, Konermann, Silvana, Johannessen, Cory M, Beroukhim, Rameen, Bandopadhayay, Pratiti, Blainey, Paul C
Published 2021

DNA targeting specificity of RNA-guided Cas9 nucleases

by Hsu, Patrick, Scott, David Arthur, Weinstein, Joshua, Ran, F. Ann, Konermann, Silvana M., Agarwala, Vineeta, Li, Yinqing, Fine, Eli J., Wu, Xavier, Shalem, Ophir, Cradick, Thomas J., Marraffini, Luciano A., Bao, Gang, Zhang, Feng
Published 2016

Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells

by Wu, Xuebing, Cheng, Albert W., Chen, Sidi, Jaenisch, Rudolf, Zhang, Feng, Chiu, Anthony Chun-yin, Sharp, Phillip A., Scott, David Arthur, Hsu, Patrick, Trevino, Alexandro E., Kriz, Andrea J., Dadon, Daniel Benjamin, Konermann, Silvana M
Published 2015

C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector

by Shmakov, S., Makarova, K. S., Semenova, E., Minakhin, L., Severinov, K., Koonin, E. V., Regev, Aviv, Gootenberg, Jonathan S, Konermann, Silvana M, Joung, Julia, Slaymaker, Ian, Cox, David Benjamin Turitz, Lander, Eric Steven, Zhang, Feng, Abudayyeh, Omar O.
Published 2016

Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity

by Ran, F. Ann, Hsu, Patrick D, Lin, Chie Yu, Gootenberg, Jonathan S., Konermann, Silvana M., Trevino, Alexandro E., Scott, David A., Inoue, Azusa, Matoba, Shogo, Zhang, Yi, Zhang, Feng, Ran, F. Ann, Scott, David Arthur, Hsu, Patrick D.
Published 2016

Genome-scale activation screen identifies a lncRNA locus regulating a gene neighbourhood

by Verdine, Vanessa K., Aguet, Francois, Fulco, Charles P., Tseng, Yuen-Yi, Boehm, Jesse S., Joung, Julia, Engreitz, Jesse Michael, Konermann, Silvana M, Gootenberg, Jonathan S, Sanjana, Neville E, Wright, Jason, Yoon, Charles, Lander, Eric Steven, Zhang, Feng, Abudayyeh, Omar O.
Published 2018