Horizontal Combination of MEK and PI3K/mTOR Inhibition in BRAF Mutant Tumor Cells with or without Concomitant PI3K Pathway Mutations

by Dominika Rittler, Eszter Molnár, Marcell Baranyi, Tamás Garay, Luca Hegedűs, Clemens Aigner, József Tóvári, József Tímár, Balázs Hegedűs
Published 2020-10-01

Expression of calcium pumps is differentially regulated by histone deacetylase inhibitors and estrogen receptor alpha in breast cancer cells

by Karolina Varga, Anna Hollósi, Katalin Pászty, Luca Hegedűs, Gergely Szakács, József Tímár, Béla Papp, Ágnes Enyedi, Rita Padányi
Published 2018-10-01

Histone Deacetylase Inhibitor Treatment Increases the Expression of the Plasma Membrane Ca2+ Pump PMCA4b and Inhibits the Migration of Melanoma Cells Independent of ERK

by Luca Hegedüs, Luca Hegedüs, Rita Padányi, Judit Molnár, Katalin Pászty, Karolina Varga, Karolina Varga, István Kenessey, Eszter Sárközy, Matthias Wolf, Michael Grusch, Zoltán Hegyi, László Homolya, Clemens Aigner, Tamás Garay, Balázs Hegedüs, Balázs Hegedüs, József Tímár, József Tímár, Enikö Kállay, Ágnes Enyedi, Ágnes Enyedi
Published 2017-05-01

Allosteric and ATP-Competitive MEK-Inhibition in a Novel Spitzoid Melanoma Model with a RAF- and Phosphorylation-Independent Mutation

by Luca Hegedüs, Özlem Okumus, Elisabeth Livingstone, Marcell Baranyi, Ildikó Kovács, Balázs Döme, József Tóvári, Ágnes Bánkfalvi, Dirk Schadendorf, Clemens Aigner, Balázs Hegedüs
Published 2021-02-01

The Plasma Membrane Ca²⁺ Pump PMCA4b Regulates Melanoma Cell Migration Through Remodeling of the Actin Cytoskeleton

by Randa Naffa, Rita Padányi, Attila Ignácz, Zoltán Hegyi, Bálint Jezsó, Sarolta Tóth, Karolina Varga, László Homolya, Luca Hegedűs, Katalin Schlett, Agnes Enyedi
Published 2021-03-01

The Antitumor Effect of Lipophilic Bisphosphonate BPH1222 in Melanoma Models: The Role of the PI3K/Akt Pathway and the Small G Protein Rheb

by Dominika Rittler, Marcell Baranyi, Eszter Molnár, Tamás Garay, István Jalsovszky, Imre Károly Varga, Luca Hegedűs, Clemens Aigner, József Tóvári, József Tímár, Balázs Hegedűs
Published 2019-10-01

P38 MAPK Promotes Migration and Metastatic Activity of BRAF Mutant Melanoma Cells by Inducing Degradation of PMCA4b

by Randa Naffa, Lisa Vogel, Luca Hegedűs, Katalin Pászty, Sarolta Tóth, Kornélia Kelemen, Neha Singh, Attila Reményi, Enikő Kállay, Mihály Cserepes, József Tóvári, Michael Grusch, Ágnes Enyedi
Published 2020-05-01