Computational Docking of Antibody-Antigen Complexes, Opportunities and Pitfalls Illustrated by Influenza Hemagglutinin

by Mattia Pedotti, Luca Simonelli, Elsa Livoti, Luca Varani
Published 2011-01-01

Opening Study on the Development of a New Biosensor for Metal Toxicity Based on Pseudomonas fluorescens Pyoverdine

by Alessandro Chiadò, Luca Varani, Francesca Bosco, Luca Marmo
Published 2013-12-01

Rational engineering of the lccβ T. versicolor laccase for the mediator-less oxidation of large polycyclic aromatic hydrocarbons

by Alessandro Chiadò, Francesca Bosco, Marco Bardelli, Luca Simonelli, Mattia Pedotti, Luca Marmo, Luca Varani
Published 2021-01-01

Rational modification of estrogen receptor by combination of computational and experimental analysis.

by Valentina Elisabetta Viviana Ferrero, Mattia Pedotti, Alessandro Chiadò, Luca Simonelli, Luigi Calzolai, Luca Varani, Teresa Lettieri
Published 2014-01-01

Rationally Modified Estrogen Receptor Protein as a Bio-Recognition Element for the Detection of EDC Pollutants: Strategies and Opportunities

by Mattia Pedotti, Valentina Elisabetta Viviana Ferrero, Teresa Lettieri, Pascal Colpo, Stephane Follonier, Luigi Calzolai, Luca Varani
Published 2015-02-01

Rational engineering of a human anti-dengue antibody through experimentally validated computational docking.

by Luca Simonelli, Mattia Pedotti, Martina Beltramello, Elsa Livoti, Luigi Calzolai, Federica Sallusto, Antonio Lanzavecchia, Luca Varani
Published 2013-01-01

Label-Free Biosensor Detection of Endocrine Disrupting Compounds Using Engineered Estrogen Receptors

by Rita La Spina, Valentina E. V. Ferrero, Venera Aiello, Mattia Pedotti, Luca Varani, Teresa Lettieri, Luigi Calzolai, Willem Haasnoot, Pascal Colpo
Published 2017-12-01

Out-of-Equilibrium Collective Oscillation as Phonon Condensation in a Model Protein

by Ilaria Nardecchia, Jeremie Torres, Mathias Lechelon, Valeria Giliberti, Michele Ortolani, Philippe Nouvel, Matteo Gori, Yoann Meriguet, Irene Donato, Jordane Preto, Luca Varani, James Sturgis, Marco Pettini
Published 2018-09-01

A bispecific immunotweezer prevents soluble PrP oligomers and abolishes prion toxicity.

by Marco Bardelli, Karl Frontzek, Luca Simonelli, Simone Hornemann, Mattia Pedotti, Federica Mazzola, Manfredi Carta, Valeria Eckhardt, Rocco D'Antuono, Tommaso Virgilio, Santiago F González, Adriano Aguzzi, Luca Varani
Published 2018-10-01

Machine learning analyses of antibody somatic mutations predict immunoglobulin light chain toxicity

by Maura Garofalo, Luca Piccoli, Margherita Romeo, Maria Monica Barzago, Sara Ravasio, Mathilde Foglierini, Milos Matkovic, Jacopo Sgrignani, Raoul De Gasparo, Marco Prunotto, Luca Varani, Luisa Diomede, Olivier Michielin, Antonio Lanzavecchia, Andrea Cavalli
Published 2021-06-01

High mobility group box 1 (HMGB1) acts as an “alarmin” to promote acute myeloid leukaemia progression

by Inna M. Yasinska, Isabel Gonçalves Silva, Svetlana S. Sakhnevych, Laura Ruegg, Rohanah Hussain, Giuliano Siligardi, Walter Fiedler, Jasmin Wellbrock, Marco Bardelli, Luca Varani, Ulrike Raap, Steffen Berger, Bernhard F. Gibbs, Elizaveta Fasler-Kan, Vadim V. Sumbayev
Published 2018-06-01

The Tim-3-galectin-9 Secretory Pathway is Involved in the Immune Escape of Human Acute Myeloid Leukemia Cells

by Isabel Gonçalves Silva, Inna M. Yasinska, Svetlana S. Sakhnevych, Walter Fiedler, Jasmin Wellbrock, Marco Bardelli, Luca Varani, Rohanah Hussain, Giuliano Siligardi, Giacomo Ceccone, Steffen M. Berger, Yuri A. Ushkaryov, Bernhard F. Gibbs, Elizaveta Fasler-Kan, Vadim V. Sumbayev
Published 2017-08-01

Ligand-Receptor Interactions of Galectin-9 and VISTA Suppress Human T Lymphocyte Cytotoxic Activity

by Inna M. Yasinska, N. Helge Meyer, Stephanie Schlichtner, Rohanah Hussain, Giuliano Siligardi, Maxwell Casely-Hayford, Walter Fiedler, Jasmin Wellbrock, Cloe Desmet, Luigi Calzolai, Luca Varani, Steffen M. Berger, Ulrike Raap, Bernhard F. Gibbs, Bernhard F. Gibbs, Elizaveta Fasler-Kan, Elizaveta Fasler-Kan, Vadim V. Sumbayev
Published 2020-11-01

The Tim-3-Galectin-9 Pathway and Its Regulatory Mechanisms in Human Breast Cancer

by Inna M. Yasinska, Svetlana S. Sakhnevych, Ludmila Pavlova, Anette Teo Hansen Selnø, Ana Maria Teuscher Abeleira, Ana Maria Teuscher Abeleira, Ouafa Benlaouer, Isabel Gonçalves Silva, Marianne Mosimann, Marianne Mosimann, Luca Varani, Marco Bardelli, Rohanah Hussain, Giuliano Siligardi, Dietmar Cholewa, Steffen M. Berger, Bernhard F. Gibbs, Bernhard F. Gibbs, Yuri A. Ushkaryov, Elizaveta Fasler-Kan, Elizaveta Fasler-Kan, Elena Klenova, Vadim V. Sumbayev
Published 2019-07-01

SARS-CoV-2 neutralizing human recombinant antibodies selected from pre-pandemic healthy donors binding at RBD-ACE2 interface

by Federico Bertoglio, Doris Meier, Nora Langreder, Stephan Steinke, Ulfert Rand, Luca Simonelli, Philip Alexander Heine, Rico Ballmann, Kai-Thomas Schneider, Kristian Daniel Ralph Roth, Maximilian Ruschig, Peggy Riese, Kathrin Eschke, Yeonsu Kim, Dorina Schäckermann, Mattia Pedotti, Philipp Kuhn, Susanne Zock-Emmenthal, Johannes Wöhrle, Normann Kilb, Tobias Herz, Marlies Becker, Martina Grasshoff, Esther Veronika Wenzel, Giulio Russo, Andrea Kröger, Linda Brunotte, Stephan Ludwig, Viola Fühner, Stefan Daniel Krämer, Stefan Dübel, Luca Varani, Günter Roth, Luka Čičin-Šain, Maren Schubert, Michael Hust
Published 2021-03-01