Exploiting DNA Damage Repair in Precision Cancer Therapy: BRCA1 as a Prime Therapeutic Target

by Liliana Raimundo, Juliana Calheiros, Lucília Saraiva
Published 2021-07-01

Boronic Acids and Their Derivatives in Medicinal Chemistry: Synthesis and Biological Applications

by Mariana Pereira Silva, Lucília Saraiva, Madalena Pinto, Maria Emília Sousa
Published 2020-09-01

Contribution of Yeast Models to Neurodegeneration Research

by Clara Pereira, Cláudia Bessa, Joana Soares, Mariana Leão, Lucília Saraiva
Published 2012-01-01

Chalcones as Promising Antitumor Agents by Targeting the p53 Pathway: An Overview and New Insights in Drug-Likeness

by Joana Moreira, Joana Almeida, Lucília Saraiva, Honorina Cidade, Madalena Pinto
Published 2021-06-01

Structural and Drug Targeting Insights on Mutant p53

by Ana Sara Gomes, Helena Ramos, Alberto Inga, Emília Sousa, Lucília Saraiva
Published 2021-07-01

Cytotoxicity of Frutalin on Distinct Cancer Cells Is Independent of Its Glycosylation

by Carla Oliveira, Ana Isabel Freitas, Nair Campos, Lucília Saraiva, Lucília Domingues
Published 2021-08-01

Contribution of Yeast and Plant Research for Improving Human Health

by Diego F. Gomez-Casati, Marina Clemente, Alberto Inga, Lucilia Saraiva, Claudia P. Spampinato
Published 2012-01-01

SNaPaer: a practical single nucleotide polymorphism multiplex assay for genotyping of Pseudomonas aeruginosa.

by Nadia Eusebio, Tiago Pinheiro, Adelina A Amorim, Fernanda Gamboa, Lucília Saraiva, Leonor Gusmão, António Amorim, Ricardo Araujo
Published 2013-01-01

SLMP53-1 Inhibits Tumor Cell Growth through Regulation of Glucose Metabolism and Angiogenesis in a P53-Dependent Manner

by Helena Ramos, Juliana Calheiros, Joana Almeida, Valentina Barcherini, Sónia Santos, Alexandra T. P. Carvalho, Maria M.M. Santos, Lucília Saraiva
Published 2020-01-01

Semi-Synthesis of Small Molecules of Aminocarbazoles: Tumor Growth Inhibition and Potential Impact on p53

by Solida Long, Joana B. Loureiro, Carla Carvalho, Luís Gales, Lucília Saraiva, Madalena M. M. Pinto, Ploenthip Puthongking, Emília Sousa
Published 2021-03-01

Synthesis, Biological Evaluation, and In Silico Studies of Novel Aminated Xanthones as Potential p53-Activating Agents

by Agostinho Lemos, Ana Sara Gomes, Joana B. Loureiro, Pedro Brandão, Andreia Palmeira, Madalena M. M. Pinto, Lucília Saraiva, Maria Emília Sousa
Published 2019-05-01

New Alkoxy Flavone Derivatives Targeting Caspases: Synthesis and Antitumor Activity Evaluation

by Joana Moreira, Diana Ribeiro, Patrícia M. A. Silva, Nair Nazareth, Madalena Monteiro, Andreia Palmeira, Lucília Saraiva, Madalena Pinto, Hassan Bousbaa, Honorina Cidade
Published 2018-12-01

Mechanism of Antifungal Activity by 5-Aminoimidazole-4-Carbohydrazonamide Derivatives against <i>Candida albicans</i> and <i>Candida krusei</i>

by Fátima Cerqueira, Marta Maia, Carla Gabriel, Rui Medeiros, Sara Cravo, Ana Isabel Ribeiro, Daniela Dantas, Alice Maria Dias, Lucília Saraiva, Liliana Raimundo, Eugénia Pinto
Published 2021-02-01

Norhierridin B, a New Hierridin B-Based Hydroquinone with Improved Antiproliferative Activity

by Pedro Brandão, Joana Moreira, Joana Almeida, Nair Nazareth, Ivo E. Sampaio-Dias, Vitor Vasconcelos, Rosário Martins, Pedro Leão, Madalena Pinto, Lucília Saraíva, Honorina Cidade
Published 2020-03-01

Cytotoxic Activity of Royleanone Diterpenes from Plectranthus madagascariensis Benth

by Diogo Matias, Marisa Nicolai, Lucília Saraiva, Rute Pinheiro, Célia Faustino, Ana Diaz Lanza, Catarina Pinto Reis, Tijana Stankovic, Jelena Dinic, Milica Pesic, Patrícia Rijo
Published 2019-05-01

Comparison Study of Different Extracts of <i>Plectranthus madagascariensis</i>, <i>P. neochilus</i> and the Rare <i>P. porcatus</i> (Lamiaceae): Chemical Characterization, Antioxid...

by Diogo Matias, Marisa Nicolai, Ana Sofia Fernandes, Nuno Saraiva, Joana Almeida, Lucília Saraiva, Célia Faustino, Ana María Díaz-Lanza, Catarina P. Reis, Patrícia Rijo
Published 2019-05-01

The Crystal Structure of the R280K Mutant of Human p53 Explains the Loss of DNA Binding

by Ana Sara Gomes, Filipa Trovão, Benedita Andrade Pinheiro, Filipe Freire, Sara Gomes, Carla Oliveira, Lucília Domingues, Maria João Romão, Lucília Saraiva, Ana Luísa Carvalho
Published 2018-04-01

Preliminary Biological Activity Screening of <i>Plectranthus</i> spp. Extracts for the Search of Anticancer Lead Molecules

by Epole Ntungwe, Eva María Domínguez-Martín, Catarina Teodósio, Silvia Teixidó Trujillo, Natalia Armas Capote, Lucilia Saraiva, Ana María Díaz-Lanza, Noélia Duarte, Patrícia Rijo
Published 2021-04-01

Activity to Breast Cancer Cell Lines of Different Malignancy and Predicted Interaction with Protein Kinase C Isoforms of Royleanones

by Vera M. S. Isca, Milan Sencanski, Nenad Filipovic, Daniel J. V. A. Dos Santos, Ana Čipak Gašparović, Lucília Saraíva, Carlos A. M. Afonso, Patrícia Rijo, Alfonso T. García-Sosa
Published 2020-05-01

Design and synthesis of new inhibitors of p53–MDM2 interaction with a chalcone scaffold

by Daniela Pereira, Raquel T. Lima, Andreia Palmeira, Hugo Seca, Joana Soares, Sara Gomes, Liliana Raimundo, Claudia Maciel, Madalena Pinto, Emília Sousa, M. Helena Vasconcelos, Lucília Saraiva, Honorina Cidade
Published 2019-12-01