Transgenic overexpression of active calcineurin in beta-cells results in decreased beta-cell mass and hyperglycemia.

by Ernesto Bernal-Mizrachi, Corentin Cras-Méneur, Bo Ra Ye, James D Johnson, M Alan Permutt
Published 2010-08-01

Gene-gene interactions lead to higher risk for development of type 2 diabetes in an Ashkenazi Jewish population.

by Rosalind J Neuman, Jon Wasson, Gil Atzmon, Julio Wainstein, Yair Yerushalmi, Joseph Cohen, Nir Barzilai, Ilana Blech, Benjamin Glaser, M Alan Permutt
Published 2010-03-01

Early brain vulnerability in Wolfram syndrome.

by Tamara Hershey, Heather M Lugar, Joshua S Shimony, Jerrel Rutlin, Jonathan M Koller, Dana C Perantie, Alex R Paciorkowski, Sarah A Eisenstein, M Alan Permutt, Washington University Wolfram Study Group
Published 2012-01-01

Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance.

by Katsuya Tanabe, Zhonghao Liu, Satish Patel, Bradley W Doble, Lin Li, Corentin Cras-Méneur, Sara C Martinez, Cris M Welling, Morris F White, Ernesto Bernal-Mizrachi, James R Woodgett, M Alan Permutt
Published 2008-02-01

Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3β independent of JNK activation.

by Katsuya Tanabe, Yang Liu, Syed D Hasan, Sara C Martinez, Corentin Cras-Méneur, Cris M Welling, Ernesto Bernal-Mizrachi, Yukio Tanizawa, Christopher J Rhodes, Erik Zmuda, Tsonwin Hai, Nada A Abumrad, M Alan Permutt
Published 2011-04-01