Prenatal Alcohol Exposure: Profiling Developmental DNA Methylation Patterns in Central and Peripheral Tissues

by Alexandre A. Lussier, Alexandre A. Lussier, Tamara S. Bodnar, Matthew Mingay, Alexandre M. Morin, Martin Hirst, Martin Hirst, Michael S. Kobor, Michael S. Kobor, Joanne Weinberg
Published 2018-12-01

Dynamic remodeling of individual nucleosomes across a eukaryotic genome in response to transcriptional perturbation.

by Sushma Shivaswamy, Akshay Bhinge, Yongjun Zhao, Steven Jones, Martin Hirst, Vishwanath R Iyer
Published 2008-03-01

Butyrate Shapes Immune Cell Fate and Function in Allergic Asthma

by William Yip, William Yip, Michael R. Hughes, Michael R. Hughes, Yicong Li, Alissa Cait, Alissa Cait, Martin Hirst, Martin Hirst, William W. Mohn, William W. Mohn, Kelly M. McNagny, Kelly M. McNagny, Kelly M. McNagny
Published 2021-02-01

Megabase-scale methylation phasing using nanopore long reads and NanoMethPhase

by Vahid Akbari, Jean-Michel Garant, Kieran O’Neill, Pawan Pandoh, Richard Moore, Marco A. Marra, Martin Hirst, Steven J. M. Jones
Published 2021-02-01

Vitamin C induces specific demethylation of H3K9me2 in mouse embryonic stem cells via Kdm3a/b

by Kevin T. Ebata, Kathryn Mesh, Shichong Liu, Misha Bilenky, Alexander Fekete, Michael G. Acker, Martin Hirst, Benjamin A. Garcia, Miguel Ramalho-Santos
Published 2017-07-01

Distinct DNA methylation patterns associated with treatment resistance in metastatic castration resistant prostate cancer

by Madonna R. Peter, Misha Bilenky, Alastair Davies, Ruth Isserlin, Gary D. Bader, Neil E. Fleshner, Martin Hirst, Amina Zoubeidi, Bharati Bapat
Published 2021-03-01

The [PSI +] yeast prion does not wildly affect proteome composition whereas selective pressure exerted on [PSI +] cells can promote aneuploidy

by Patrick H. W. Chan, Lisa Lee, Erin Kim, Tony Hui, Nikolay Stoynov, Roy Nassar, Michelle Moksa, Dale M. Cameron, Martin Hirst, Joerg Gsponer, Thibault Mayor
Published 2017-08-01

Characterization of the contradictory chromatin signatures at the 3' exons of zinc finger genes.

by Kimberly R Blahnik, Lei Dou, Lorigail Echipare, Sushma Iyengar, Henriette O'Geen, Erica Sanchez, Yongjun Zhao, Marco A Marra, Martin Hirst, Joseph F Costello, Ian Korf, Peggy J Farnham
Published 2011-02-01

Retrotransposon-induced heterochromatin spreading in the mouse revealed by insertional polymorphisms.

by Rita Rebollo, Mohammad M Karimi, Misha Bilenky, Liane Gagnier, Katharine Miceli-Royer, Ying Zhang, Preeti Goyal, Thomas M Keane, Steven Jones, Martin Hirst, Matthew C Lorincz, Dixie L Mager
Published 2011-09-01

High-Resolution Single-Cell DNA Methylation Measurements Reveal Epigenetically Distinct Hematopoietic Stem Cell Subpopulations

by Tony Hui, Qi Cao, Joanna Wegrzyn-Woltosz, Kieran O'Neill, Colin A. Hammond, David J.H.F. Knapp, Emma Laks, Michelle Moksa, Samuel Aparicio, Connie J. Eaves, Aly Karsan, Martin Hirst
Published 2018-08-01

Atrophin controls developmental signaling pathways via interactions with Trithorax-like

by Kelvin Yeung, Ann Boija, Edvin Karlsson, Per-Henrik Holmqvist, Yonit Tsatskis, Ilaria Nisoli, Damian Yap, Alireza Lorzadeh, Michelle Moksa, Martin Hirst, Samuel Aparicio, Manolis Fanto, Per Stenberg, Mattias Mannervik, Helen McNeill
Published 2017-03-01

Human Illness from Avian Influenza H7N3, British Columbia

by S. Aleina Tweed, Danuta M. Skowronski, Samara T. David, Andrew Larder, Martin Petric, Wayne Lees, Yan Li, Jacqueline M. Katz, Mel Krajden, Raymond Tellier, Christine Halpert, Martin Hirst, Caroline Astell, David Lawrence, Annie Mak
Published 2004-12-01

Mutation discovery in regions of segmental cancer genome amplifications with CoNAn-SNV: a mixture model for next generation sequencing of tumors.

by Anamaria Crisan, Rodrigo Goya, Gavin Ha, Jiarui Ding, Leah M Prentice, Arusha Oloumi, Janine Senz, Thomas Zeng, Kane Tse, Allen Delaney, Marco A Marra, David G Huntsman, Martin Hirst, Sam Aparicio, Sohrab Shah
Published 2012-01-01

deFuse: an algorithm for gene fusion discovery in tumor RNA-Seq data.

by Andrew McPherson, Fereydoun Hormozdiari, Abdalnasser Zayed, Ryan Giuliany, Gavin Ha, Mark G F Sun, Malachi Griffith, Alireza Heravi Moussavi, Janine Senz, Nataliya Melnyk, Marina Pacheco, Marco A Marra, Martin Hirst, Torsten O Nielsen, S Cenk Sahinalp, David Huntsman, Sohrab P Shah
Published 2011-05-01

Epiclomal: Probabilistic clustering of sparse single-cell DNA methylation data.

by Camila P E de Souza, Mirela Andronescu, Tehmina Masud, Farhia Kabeer, Justina Biele, Emma Laks, Daniel Lai, Patricia Ye, Jazmine Brimhall, Beixi Wang, Edmund Su, Tony Hui, Qi Cao, Marcus Wong, Michelle Moksa, Richard A Moore, Martin Hirst, Samuel Aparicio, Sohrab P Shah
Published 2020-09-01

Autophagy Regulation of Metabolism Is Required for CD8+ T Cell Anti-tumor Immunity

by Lindsay DeVorkin, Nils Pavey, Gillian Carleton, Alexandra Comber, Cally Ho, Junghyun Lim, Erin McNamara, Haochu Huang, Paul Kim, Lauren G. Zacharias, Noboru Mizushima, Tatsuya Saitoh, Shizuo Akira, Wayne Beckham, Alireza Lorzadeh, Michelle Moksa, Qi Cao, Aditya Murthy, Martin Hirst, Ralph J. DeBerardinis, Julian J. Lum
Published 2019-04-01

Synthetic modeling reveals HOXB genes are critical for the initiation and maintenance of human leukemia

by Manabu Kusakabe, Ann Chong Sun, Kateryna Tyshchenko, Rachel Wong, Aastha Nanda, Claire Shanna, Samuel Gusscott, Elizabeth A. Chavez, Alireza Lorzadeh, Alice Zhu, Ainsleigh Hill, Stacy Hung, Scott Brown, Artem Babaian, Xuehai Wang, Robert A. Holt, Christian Steidl, Aly Karsan, R. Keith Humphries, Connie J. Eaves, Martin Hirst, Andrew P. Weng
Published 2019-07-01

Increasing quality, throughput and speed of sample preparation for strand-specific messenger RNA sequencing

by Simon Haile, Richard D. Corbett, Tina MacLeod, Steve Bilobram, Duane Smailus, Philip Tsao, Heather Kirk, Helen McDonald, Pawan Pandoh, Miruna Bala, Martin Hirst, Diane Miller, Richard A. Moore, Andrew J. Mungall, Jacquie Schein, Robin J. Coope, Yussanne Ma, Yongjun Zhao, Rob A. Holt, Steven J. Jones, Marco A. Marra
Published 2017-07-01

Automated high throughput nucleic acid purification from formalin-fixed paraffin-embedded tissue samples for next generation sequence analysis.

by Simon Haile, Pawan Pandoh, Helen McDonald, Richard D Corbett, Philip Tsao, Heather Kirk, Tina MacLeod, Martin Jones, Steve Bilobram, Denise Brooks, Duane Smailus, Christian Steidl, David W Scott, Miruna Bala, Martin Hirst, Diane Miller, Richard A Moore, Andrew J Mungall, Robin J Coope, Yussanne Ma, Yongjun Zhao, Rob A Holt, Steven J Jones, Marco A Marra
Published 2017-01-01

MeCP2-E1 isoform is a dynamically expressed, weakly DNA-bound protein with different protein and DNA interactions compared to MeCP2-E2

by Alexia Martínez de Paz, Leila Khajavi, Hélène Martin, Rafael Claveria-Gimeno, Susanne Tom Dieck, Manjinder S. Cheema, Jose V. Sanchez-Mut, Malgorzata M. Moksa, Annaick Carles, Nick I. Brodie, Taimoor I. Sheikh, Melissa E. Freeman, Evgeniy V. Petrotchenko, Christoph H. Borchers, Erin M. Schuman, Matthias Zytnicki, Adrian Velazquez-Campoy, Olga Abian, Martin Hirst, Manel Esteller, John B. Vincent, Cécile E. Malnou, Juan Ausió
Published 2019-10-01