The Innate Immune Playbook for Restricting West Nile Virus Infection

by Kendra M. Quicke, Mehul S. Suthar
Published 2013-10-01

Innate immune sensing of flaviviruses.

by Mehul S Suthar, Sebastian Aguirre, Ana Fernandez-Sesma
Published 2013-09-01

Induction of IFN-beta and the innate antiviral response in myeloid cells occurs through an IPS-1-dependent signal that does not require IRF-3 and IRF-7.

by Stephane Daffis, Mehul S Suthar, Kristy J Szretter, Michael Gale, Michael S Diamond
Published 2009-10-01

Rabies virus infection induces type I interferon production in an IPS-1 dependent manner while dendritic cell activation relies on IFNAR signaling.

by Elizabeth J Faul, Celestine N Wanjalla, Mehul S Suthar, Michael Gale, Christoph Wirblich, Matthias J Schnell
Published 2010-07-01

Interferon regulatory factor-1 (IRF-1) shapes both innate and CD8(+) T cell immune responses against West Nile virus infection.

by James D Brien, Stephane Daffis, Helen M Lazear, Hyelim Cho, Mehul S Suthar, Michael Gale, Michael S Diamond
Published 2011-09-01

Dendritic cell-associated MAVS is required to control West Nile virus replication and ensuing humoral immune responses.

by Kelsey Roe, Daniela Giordano, Lucy B Young, Kevin E Draves, Ursula Holder, Mehul S Suthar, Michael Gale, Edward A Clark
Published 2019-01-01

Acetaminophen Intoxication Rapidly Induces Apoptosis of Intestinal Crypt Stem Cells and Enhances Intestinal Permeability

by Daniel M. Chopyk, Johnasha D. Stuart, Matthew G. Zimmerman, Jing Wen, Sanjeev Gumber, Mehul S. Suthar, Manoj Thapa, Mark J. Czaja, Arash Grakoui
Published 2019-11-01

Pre-Existing Dengue Immunity Drives a DENV-Biased Plasmablast Response in ZIKV-Infected Patient

by Siddhartha K. Bhaumik, Lalita Priyamvada, Robert C. Kauffman, Lilin Lai, Muktha S. Natrajan, Alice Cho, Nadine Rouphael, Mehul S. Suthar, Mark J. Mulligan, Jens Wrammert
Published 2018-12-01

A systems biology approach reveals that tissue tropism to West Nile virus is regulated by antiviral genes and innate immune cellular processes.

by Mehul S Suthar, Margaret M Brassil, Gabriele Blahnik, Aimee McMillan, Hilario J Ramos, Sean C Proll, Sarah E Belisle, Michael G Katze, Michael Gale
Published 2013-02-01

Structural basis for potent neutralization of SARS-CoV-2 and role of antibody affinity maturation

by Nicholas K. Hurlburt, Emilie Seydoux, Yu-Hsin Wan, Venkata Viswanadh Edara, Andrew B. Stuart, Junli Feng, Mehul S. Suthar, Andrew T. McGuire, Leonidas Stamatatos, Marie Pancera
Published 2020-10-01

Deficient IFN signaling by myeloid cells leads to MAVS-dependent virus-induced sepsis.

by Amelia K Pinto, Hilario J Ramos, Xiaobo Wu, Shilpa Aggarwal, Bimmi Shrestha, Matthew Gorman, Kristin Y Kim, Mehul S Suthar, John P Atkinson, Michael Gale, Michael S Diamond
Published 2014-04-01

Zika Virus Antagonizes Type I Interferon Responses during Infection of Human Dendritic Cells.

by James R Bowen, Kendra M Quicke, Mohan S Maddur, Justin T O'Neal, Circe E McDonald, Nadia B Fedorova, Vinita Puri, Reed S Shabman, Bali Pulendran, Mehul S Suthar
Published 2017-02-01

IL-1β signaling promotes CNS-intrinsic immune control of West Nile virus infection.

by Hilario J Ramos, Marion C Lanteri, Gabriele Blahnik, Amina Negash, Mehul S Suthar, Margaret M Brassil, Khushbu Sodhi, Piper M Treuting, Michael P Busch, Philip J Norris, Michael Gale
Published 2012-01-01

IPS-1 is essential for the control of West Nile virus infection and immunity.

by Mehul S Suthar, Daphne Y Ma, Sunil Thomas, Jennifer M Lund, Nu Zhang, Stephane Daffis, Alexander Y Rudensky, Michael J Bevan, Edward A Clark, Murali-Krishna Kaja, Michael S Diamond, Michael Gale
Published 2010-02-01

SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity

by Lizhou Zhang, Cody B. Jackson, Huihui Mou, Amrita Ojha, Haiyong Peng, Brian D. Quinlan, Erumbi S. Rangarajan, Andi Pan, Abigail Vanderheiden, Mehul S. Suthar, Wenhui Li, Tina Izard, Christoph Rader, Michael Farzan, Hyeryun Choe
Published 2020-11-01

The amphibian peptide Yodha is virucidal for Zika and dengue viruses

by Song Hee Lee, Eui Ho Kim, Justin T. O’neal, Gordon Dale, David J. Holthausen, James R. Bowen, Kendra M. Quicke, Ioanna Skountzou, Shyla Gopal, Sanil George, Jens Wrammert, Mehul S. Suthar, Joshy Jacob
Published 2021-01-01

Correction: IRF-3, IRF-5, and IRF-7 Coordinately Regulate the Type I IFN Response in Myeloid Dendritic Cells Downstream of MAVS Signaling.

by Helen M. Lazear, Alissa Lancaster, Courtney Wilkins, Mehul S. Suthar, Albert Huang, Sarah C. Vick, Lisa Clepper, Larissa Thackray, Margaret M. Brassil, Herbert W. Virgin, Janko Nikolich-Zugich, Ashlee V. Moses, Michael Gale, Klaus Früh, Michael S. Diamond
Published 2013-05-01

IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling.

by Helen M Lazear, Alissa Lancaster, Courtney Wilkins, Mehul S Suthar, Albert Huang, Sarah C Vick, Lisa Clepper, Larissa Thackray, Margaret M Brassil, Herbert W Virgin, Janko Nikolich-Zugich, Ashlee V Moses, Michael Gale, Klaus Früh, Michael S Diamond
Published 2013-01-01

Long-term alterations in brain and behavior after postnatal Zika virus infection in infant macaques

by Jessica Raper, Zsofia Kovacs-Balint, Maud Mavigner, Sanjeev Gumber, Mark W. Burke, Jakob Habib, Cameron Mattingly, Damien Fair, Eric Earl, Eric Feczko, Martin Styner, Sherrie M. Jean, Joyce K. Cohen, Mehul S. Suthar, Mar M. Sanchez, Maria C. Alvarado, Ann Chahroudi
Published 2020-05-01

An intranasal vaccine durably protects against SARS-CoV-2 variants in mice

by Ahmed O. Hassan, Swathi Shrihari, Matthew J. Gorman, Baoling Ying, Dansu Yaun, Saravanan Raju, Rita E. Chen, Igor P. Dmitriev, Elena Kashentseva, Lucas J. Adams, Colin Mann, Meredith E. Davis-Gardner, Mehul S. Suthar, Pei-Yong Shi, Erica Ollmann Saphire, Daved H. Fremont, David T. Curiel, Galit Alter, Michael S. Diamond
Published 2021-07-01