Resistance Analyses of Integrase Strand Transfer Inhibitors within Phase 3 Clinical Trials of Treatment-Naive Patients

by Kirsten L. White, Francois Raffi, Michael D. Miller
Published 2014-07-01

Contribution of human immunodeficiency virus type 1 minority variants to reduced drug susceptibility in patients on an integrase strand transfer inhibitor-based therapy.

by Richard M Gibson, Jan Weber, Dane Winner, Michael D Miller, Miguel E Quiñones-Mateu
Published 2014-01-01

Development of elvitegravir resistance and linkage of integrase inhibitor mutations with protease and reverse transcriptase resistance mutations.

by Mark A Winters, Robert M Lloyd, Robert W Shafer, Michael J Kozal, Michael D Miller, Mark Holodniy
Published 2012-01-01

Emergent HIV-1 Drug Resistance Mutations Were Not Present at Low-Frequency at Baseline in Non-Nucleoside Reverse Transcriptase Inhibitor-Treated Subjects in the STaR Study

by Danielle P. Porter, Martin Daeumer, Alexander Thielen, Silvia Chang, Ross Martin, Cal Cohen, Michael D. Miller, Kirsten L. White
Published 2015-12-01

Lack of impact of pre-existing T97A HIV-1 integrase mutation on integrase strand transfer inhibitor resistance and treatment outcome.

by Michael E Abram, Renee R Ram, Nicolas A Margot, Tiffany L Barnes, Kirsten L White, Christian Callebaut, Michael D Miller
Published 2017-01-01

Resistance mutations outside the integrase coding region have an effect on human immunodeficiency virus replicative fitness but do not affect its susceptibility to integrase strand...

by Jan Weber, Justine D Rose, Ana C Vazquez, Dane Winner, Nicolas Margot, Damian J McColl, Michael D Miller, Miguel E Quiñones-Mateu
Published 2013-01-01

Mechanistic Study of Common Non-Nucleoside Reverse Transcriptase Inhibitor-Resistant Mutations with K103N and Y181C Substitutions

by Ming-Tain Lai, Vandna Munshi, Meiqing Lu, MeiZhen Feng, Renee Hrin-Solt, Philip M. McKenna, Daria J. Hazuda, Michael D. Miller
Published 2016-09-01

CD8+ lymphocytes control viral replication in SIVmac239-infected rhesus macaques without decreasing the lifespan of productively infected cells.

by Nichole R Klatt, Emi Shudo, Alex M Ortiz, Jessica C Engram, Mirko Paiardini, Benton Lawson, Michael D Miller, James Else, Ivona Pandrea, Jacob D Estes, Cristian Apetrei, Joern E Schmitz, Ruy M Ribeiro, Alan S Perelson, Guido Silvestri
Published 2010-01-01

A Novel Assay to Measure the Magnitude of the Inducible Viral Reservoir in HIV-infected Individuals

by Francesco Andrea Procopio, Rémi Fromentin, Deanna A. Kulpa, Jessica H. Brehm, Anne-Gaelle Bebin, Matthew C. Strain, Douglas D. Richman, Una O'Doherty, Sarah Palmer, Frederick M. Hecht, Rebecca Hoh, Richard J.O. Barnard, Michael D. Miller, Daria J. Hazuda, Steven G. Deeks, Rafick-Pierre Sékaly, Nicolas Chomont
Published 2015-08-01