Overcoming the Refractory Expression of Secreted Recombinant Proteins in Mammalian Cells through Modification of the Signal Peptide and Adjacent Amino Acids.

by Gülin Güler-Gane, Sara Kidd, Sudharsan Sridharan, Tristan J Vaughan, Trevor C I Wilkinson, Natalie J Tigue
Published 2016-01-01

Exosomal delivery of doxorubicin enables rapid cell entry and enhanced in vitro potency.

by Christina Schindler, Andie Collinson, Carl Matthews, Amy Pointon, Lesley Jenkinson, Ralph R Minter, Tristan J Vaughan, Natalie J Tigue
Published 2019-01-01

MEDI1873, a potent, stabilized hexameric agonist of human GITR with regulatory T-cell targeting potential

by Natalie J. Tigue, Lisa Bamber, John Andrews, Samantha Ireland, James Hair, Edward Carter, Sudharsan Sridharan, Jelena Jovanović, D. Gareth Rees, Jeremy S. Springall, Emilie Solier, Yi-Ming Li, Matthieu Chodorge, David Perez-Martinez, Daniel R. Higazi, Michael Oberst, Maureen Kennedy, Chelsea M. Black, Li Yan, Martin Schwickart, Shaun Maguire, Jennifer A. Cann, Lolke de Haan, Lesley L. Young, Tristan Vaughan, Robert W. Wilkinson, Ross Stewart
Published 2017-03-01