Jointly Modelling Single Nucleotide Polymorphisms With Longitudinal and Time-to-Event Trait: An Application to Type 2 Diabetes and Fasting Plasma Glucose

by Mickaël Canouil, Mickaël Canouil, Mickaël Canouil, Beverley Balkau, Beverley Balkau, Beverley Balkau, Ronan Roussel, Ronan Roussel, Ronan Roussel, Philippe Froguel, Philippe Froguel, Philippe Froguel, Philippe Froguel, Ghislain Rocheleau, Ghislain Rocheleau, Ghislain Rocheleau
Published 2018-06-01

Cofactors As Metabolic Sensors Driving Cell Adaptation in Physiology and Disease

by Nabil Rabhi, Nabil Rabhi, Nabil Rabhi, Sarah Anissa Hannou, Sarah Anissa Hannou, Sarah Anissa Hannou, Philippe Froguel, Philippe Froguel, Philippe Froguel, Philippe Froguel, Jean-Sébastien Annicotte, Jean-Sébastien Annicotte, Jean-Sébastien Annicotte
Published 2017-11-01

Role of the Unfolded Protein Response in β Cell Compensation and Failure during Diabetes

by Nabil Rabhi, Elisabet Salas, Philippe Froguel, Jean-Sébastien Annicotte
Published 2014-01-01

Comment on: Valette et al. Melanocortin-4 receptor mutations and polymorphisms do not affect weight loss after bariatric surgery. PLOS ONE 2012; 7(11):E48221.

by David Meyre, Philippe Froguel, Fritz F Horber, John G Kral
Published 2014-01-01

Role of Ink4a/Arf Locus in Beta Cell Mass Expansion under Physiological and Pathological Conditions

by Elisabet Salas, Nabil Rabhi, Philippe Froguel, Jean-Sébastien Annicotte
Published 2014-01-01

Emerging Roles for the <i>INK4a/ARF</i> (<i>CDKN2A</i>) Locus in Adipose Tissue: Implications for Obesity and Type 2 Diabetes

by Yasmina Kahoul, Frédérik Oger, Jessica Montaigne, Philippe Froguel, Christophe Breton, Jean-Sébastien Annicotte
Published 2020-09-01

Induction of TDO2 and IDO2 in Liver by High-Fat Feeding in Mice: Discrepancies with Human Obesity

by Odile Poulain-Godefroy, Elodie Eury, Audrey Leloire, Benjamin Hennart, Gilles J. Guillemin, Delphine Allorge, Philippe Froguel
Published 2013-01-01

Induction of TDO2 and IDO2 in Liver by High-Fat Feeding in Mice: Discrepancies with Human Obesity

by Odile Poulain-Godefroy, Elodie Eury, Audrey Leloire, Benjamin Hennart, Gilles J. Guillemin, Delphine Allorge, Philippe Froguel
Published 2013-07-01

Inflammatory Role of Toll-Like Receptors in Human and Murine Adipose Tissue

by Odile Poulain-Godefroy, Olivier Le Bacquer, Pauline Plancq, Cécile Lecœur, François Pattou, Gema Frühbeck, Philippe Froguel
Published 2010-01-01

Low-dose exposure to bisphenols A, F and S of human primary adipocyte impacts coding and non-coding RNA profiles.

by Marie Verbanck, Mickaël Canouil, Audrey Leloire, Véronique Dhennin, Xavier Coumoul, Loïc Yengo, Philippe Froguel, Odile Poulain-Godefroy
Published 2017-01-01

Circadian, Sleep and Caloric Intake Phenotyping in Type 2 Diabetes Patients With Rare Melatonin Receptor 2 Mutations and Controls: A Pilot Study

by Akram Imam, Eva C. Winnebeck, Nina Buchholz, Philippe Froguel, Philippe Froguel, Amélie Bonnefond, Amélie Bonnefond, Michele Solimena, Anna Ivanova, Michel Bouvier, Bianca Plouffe, Bianca Plouffe, Guillaume Charpentier, Angeliki Karamitri, Ralf Jockers, Till Roenneberg, Céline Vetter, Céline Vetter
Published 2020-10-01

Generation of an induced pluripotent stem cell (iPSC) line from a patient with maturity-onset diabetes of the young type 13 (MODY13) with a the potassium inwardly-rectifying channe...

by Frank Griscelli, Olivier Feraud, Tony Ernault, Noufissa Oudrihri, Ali G. Turhan, Amélie Bonnefond, Philippe Froguel, Annelise Bennaceur-Griscelli
Published 2017-08-01

Identification of a variable number of tandem repeats polymorphism and characterization of LEF-1 response elements in the promoter of the IDO1 gene.

by Marion Soichot, Benjamin Hennart, Alaa Al Saabi, Audrey Leloire, Philippe Froguel, Claire Levy-Marchal, Odile Poulain-Godefroy, Delphine Allorge
Published 2011-01-01

Signatures of TSPAN8 variants associated with human metabolic regulation and diseases

by Tisham De, Angela Goncalves, Doug Speed, Philippe Froguel, Daniel J. Gaffney, Michael R. Johnson, Marjo-Riitta Jarvelin, Lachlan JM. Coin
Published 2021-08-01

Meal frequencies modify the effect of common genetic variants on body mass index in adolescents of the northern Finland birth cohort 1986.

by Anne Jääskeläinen, Ursula Schwab, Marjukka Kolehmainen, Marika Kaakinen, Markku J Savolainen, Philippe Froguel, Stéphane Cauchi, Marjo-Riitta Järvelin, Jaana Laitinen
Published 2013-01-01

Generation of an induced pluripotent stem cell (iPSC) line from a patient with maturity-onset diabetes of the young type 3 (MODY3) carrying a hepatocyte nuclear factor 1-alpha (HNF...

by Frank Griscelli, Hélène Ezanno, Mathis Soubeyrand, Olivier Feraud, Noufissa Oudrhiri, Amélie Bonnefond, Ali G. Turhan, Philippe Froguel, Annelise Bennaceur-Griscelli
Published 2018-05-01

The interplay of variants near LEKR and CCNL1 and social stress in relation to birth size.

by Anokhi Ali Khan, Alina Rodriguez, Sylvain Sebert, Marika Kaakinen, Stéphane Cauchi, Philippe Froguel, Anna-Liisa Hartikainen, Anneli Pouta, Marjo-Riitta Järvelin
Published 2012-01-01

Impact of statistical models on the prediction of type 2 diabetes using non-targeted metabolomics profiling

by Loic Yengo, Abdelilah Arredouani, Michel Marre, Ronan Roussel, Martine Vaxillaire, Mario Falchi, Abdelali Haoudi, Jean Tichet, Beverley Balkau, Amélie Bonnefond, Philippe Froguel
Published 2016-10-01

A de novo synonymous variant in EFTUD2 disrupts normal splicing and causes mandibulofacial dysostosis with microcephaly: case report

by Arthur Jacob, Jennifer Pasquier, Raphael Carapito, Frédéric Auradé, Anne Molitor, Philippe Froguel, Khalid Fakhro, Najeeb Halabi, Géraldine Viot, Seiamak Bahram, Arash Rafii
Published 2020-09-01

Small deletion variants have stable breakpoints commonly associated with alu elements.

by Adam J de Smith, Robin G Walters, Lachlan J M Coin, Israel Steinfeld, Zohar Yakhini, Rob Sladek, Philippe Froguel, Alexandra I F Blakemore
Published 2008-08-01