Rate-of-Kill (RoK) assays to triage large compound sets for Chagas disease drug discovery: Application to GSK Chagas Box.

by Juan Cantizani, Pablo Gamallo, Ignacio Cotillo, Raquel Alvarez-Velilla, Julio Martin
Published 2021-07-01

Target-based vs. phenotypic screenings in Leishmania drug discovery: A marriage of convenience or a dialogue of the deaf?

by Rosa M. Reguera, Estefanía Calvo-Álvarez, Raquel Álvarez-Velilla, Rafael Balaña-Fouce
Published 2014-12-01

Trypanosomatids topoisomerase re-visited. New structural findings and role in drug discovery

by Rafael Balaña-Fouce, Raquel Álvarez-Velilla, Christopher Fernández-Prada, Carlos García-Estrada, Rosa M. Reguera
Published 2014-12-01

Synthesis of Marine α-Methoxylated Fatty Acid Analogs that Effectively Inhibit the Topoisomerase IB from Leishmania donovani with a Mechanism Different from that of Camptothecin

by Rosa M. Reguera, Christopher F. Prada, Raquel Alvarez-Velilla, Nashbly Montano, Néstor M. Carballeira, Rafael Balaña-Fouce
Published 2013-09-01

Identification and characterization of the regions involved in the nuclear translocation of the heterodimeric leishmanial DNA topoisomerase IB.

by Christopher F Prada, Raquel Álvarez-Velilla, Rosario Díaz-Gozález, Yolanda Pérez-Pertejo, Rafael Balaña-Fouce, Rosa M Reguera
Published 2013-01-01

Correction: First Evidence of Intraclonal Genetic Exchange in Trypanosomatids Using Two Leishmania infantum Fluorescent Transgenic Clones.

by Estefanía Calvo-Álvarez, Raquel Álvarez-Velilla, Maribel Jiménez, Ricardo Molina, Yolanda Pérez-Pertejo, Rafael Balaña-Fouce, Rosa M Reguera
Published 2016-05-01

First evidence of intraclonal genetic exchange in trypanosomatids using two Leishmania infantum fluorescent transgenic clones.

by Estefanía Calvo-Álvarez, Raquel Álvarez-Velilla, Maribel Jiménez, Ricardo Molina, Yolanda Pérez-Pertejo, Rafael Balaña-Fouce, Rosa M Reguera
Published 2014-09-01

Antiparasitic effect of synthetic aromathecins on Leishmania infantum

by Rosa M. Reguera, Raquel Álvarez-Velilla, Bárbara Domínguez-Asenjo, Camino Gutiérrez-Corbo, Rafael Balaña-Fouce, Mark Cushman, Yolanda Pérez-Pertejo
Published 2019-11-01

Topoisomerase IB poisons induce histone H2A phosphorylation as a response to DNA damage in Leishmania infantum

by Camino Gutiérrez-Corbo, Raquel Álvarez-Velilla, Rosa M. Reguera, Carlos García-Estrada, Mark Cushman, Rafael Balaña-Fouce, Yolanda Pérez-Pertejo
Published 2019-12-01

A chronic bioluminescent model of experimental visceral leishmaniasis for accelerating drug discovery.

by Raquel Álvarez-Velilla, Maria Del Camino Gutiérrez-Corbo, Carmen Punzón, Maria Yolanda Pérez-Pertejo, Rafael Balaña-Fouce, Manuel Fresno, Rosa María Reguera
Published 2019-02-01

Infrared fluorescent imaging as a potent tool for in vitro, ex vivo and in vivo models of visceral leishmaniasis.

by Estefanía Calvo-Álvarez, Kostantinos Stamatakis, Carmen Punzón, Raquel Álvarez-Velilla, Ana Tejería, José Miguel Escudero-Martínez, Yolanda Pérez-Pertejo, Manuel Fresno, Rafael Balaña-Fouce, Rosa M Reguera
Published 2015-03-01

Appraisal of a Leishmania major strain stably expressing mCherry fluorescent protein for both in vitro and in vivo studies of potential drugs and vaccine against cutaneous leishman...

by Estefania Calvo-Álvarez, Nestor Adrian Guerrero, Raquel Alvarez-Velilla, Christopher Fernández Prada, Jose María Requena, Carmen Punzón, Miguel Ángel Llamas, Francisco J Arévalo, Luis Rivas, Manuel Fresno, Yolanda Pérez-Pertejo, Rafael Balaña-Fouce, Rosa M Reguera
Published 2012-01-01