β-Catenin Directs Nuclear Factor-κB p65 Output via CREB-Binding Protein/p300 in Human Airway Smooth Muscle

by Tim Koopmans, Tim Koopmans, Roos Eilers, Roos Eilers, Mark Menzen, Mark Menzen, Andrew Halayko, Reinoud Gosens, Reinoud Gosens
Published 2017-09-01

Mechanistic overlap between chronic lung injury and cancer: ERS Lung Science Conference 2017 report

by Reinoud Gosens, Adam Giangreco, Erik Sahai, Rachel C. Chambers
Published 2017-06-01

Human pluripotent stem cells for the modelling and treatment of respiratory diseases

by Pien A. Goldsteen, Christina Yoseif, Amalia M. Dolga, Reinoud Gosens
Published 2021-08-01

The Enhanced Adhesion of Eosinophils Is Associated with Their Prolonged Viability and Pro-Proliferative Effect in Asthma

by Andrius Januskevicius, Ieva Janulaityte, Virginija Kalinauskaite-Zukauske, Reinoud Gosens, Kestutis Malakauskas
Published 2019-08-01

Wnt-5A/B Signaling in Hematopoiesis throughout Life

by Marina Mastelaro de Rezende, Giselle Zenker Justo, Edgar Julian Paredes-Gamero, Reinoud Gosens
Published 2020-07-01

Pharmacological Rationale for Targeting IL-17 in Asthma

by Siti Farah Rahmawati, Siti Farah Rahmawati, Siti Farah Rahmawati, Maurice te Velde, Maurice te Velde, Huib A. M. Kerstjens, Huib A. M. Kerstjens, Alexander S. S. Dömling, Matthew Robert Groves, Reinoud Gosens, Reinoud Gosens
Published 2021-08-01

TGF-β-activated kinase 1 (TAK1) signaling regulates TGF-β-induced WNT-5A expression in airway smooth muscle cells via Sp1 and β-catenin.

by Kuldeep Kumawat, Mark H Menzen, Ralph M Slegtenhorst, Andrew J Halayko, Martina Schmidt, Reinoud Gosens
Published 2014-01-01

Bronchoconstriction Induces TGF-β Release and Airway Remodelling in Guinea Pig Lung Slices.

by Tjitske A Oenema, Harm Maarsingh, Marieke Smit, Geny M M Groothuis, Herman Meurs, Reinoud Gosens
Published 2013-01-01

How to get the most out of the ERS International Congress 2021 and an overview of the Early Career Member session

by Amy Farr, Niki Ubags, Christopher Brightling, Marc Miravitlles, Miriam Barrecheguren, Pierantonio Laveneziana, Reinoud Gosens, Richard Costello, Joana Cruz
Published 2021-06-01

Rho-Kinase 1/2 Inhibition Prevents Transforming Growth Factor-β-Induced Effects on Pulmonary Remodeling and Repair

by Xinhui Wu, Xinhui Wu, Vicky Verschut, Manon E. Woest, Manon E. Woest, Manon E. Woest, John-Poul Ng-Blichfeldt, John-Poul Ng-Blichfeldt, Ana Matias, Ana Matias, Gino Villetti, Alessandro Accetta, Fabrizio Facchinetti, Reinoud Gosens, Reinoud Gosens, Loes E. M. Kistemaker, Loes E. M. Kistemaker, Loes E. M. Kistemaker
Published 2021-01-01

Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiationResearch in context

by John-Poul Ng-Blichfeldt, Anneke Schrik, Rosa K. Kortekaas, Jacobien A. Noordhoek, Irene H. Heijink, Pieter S. Hiemstra, Jan Stolk, Melanie Königshoff, Reinoud Gosens
Published 2018-10-01

Mesenchymal WNT-5A/5B Signaling Represses Lung Alveolar Epithelial Progenitors

by Xinhui Wu, Eline M. van Dijk, John-Poul Ng-Blichfeldt, I. Sophie T. Bos, Chiara Ciminieri, Melanie Königshoff, Loes E.M. Kistemaker, Reinoud Gosens
Published 2019-09-01

Bronchial smooth muscle cells of asthmatics promote angiogenesis through elevated secretion of CXC-chemokines (ENA-78, GRO-α, and IL-8).

by Laura Keglowich, Michael Roth, Maria Philippova, Thérèse Resink, Gavin Tjin, Brian Oliver, Didier Lardinois, Sophie Dessus-Babus, Reinoud Gosens, Katrin Hostettler Haack, Michael Tamm, Peter Borger
Published 2013-01-01

A Novel, Pan-PDE Inhibitor Exerts Anti-Fibrotic Effects in Human Lung Fibroblasts via Inhibition of TGF-β Signaling and Activation of cAMP/PKA Signaling

by Katarzyna Wójcik-Pszczoła, Grażyna Chłoń-Rzepa, Agnieszka Jankowska, Marietta Ślusarczyk, Paweł E Ferdek, Agnieszka A Kusiak, Artur Świerczek, Krzysztof Pociecha, Paulina Koczurkiewicz-Adamczyk, Elżbieta Wyska, Elżbieta Pękala, Reinoud Gosens
Published 2020-06-01

Activation of WNT/β-catenin signaling in pulmonary fibroblasts by TGF-β₁ is increased in chronic obstructive pulmonary disease.

by Hoeke A Baarsma, Anita I R Spanjer, Gertruud Haitsma, Lilian H J M Engelbertink, Herman Meurs, Marnix R Jonker, Wim Timens, Dirkje S Postma, Huib A M Kerstjens, Reinoud Gosens
Published 2011-01-01

The novel TRPA1 antagonist BI01305834 inhibits ovalbumin-induced bronchoconstriction in guinea pigs

by Mariska P. M. van den Berg, Susan Nijboer-Brinksma, I. Sophie T. Bos, Maarten van den Berge, David Lamb, Martijn van Faassen, Ido P. Kema, Reinoud Gosens, Loes E. M. Kistemaker
Published 2021-02-01

Airway and parenchymal strains during bronchoconstriction in the precision cut lung slice

by Jonathan E Hiorns, Cecile M Bidan, Cecile M Bidan, Cecile M Bidan, Oliver E. Jensen, Reinoud Gosens, Jeffrey J Fredberg, Loes E.M. Kistemaker, Jim P Butler, Ramaswamy Krishnan, Bindi S Brook
Published 2016-07-01

D-dopachrome tautomerase contributes to lung epithelial repair via atypical chemokine receptor 3-dependent Akt signaling

by Shanshan Song, Bin Liu, Habibie Habibie, Jelle van den Bor, Martine J. Smit, Reinoud Gosens, Xinhui Wu, Corry-Anke Brandsma, Robbert H. Cool, Hidde J. Haisma, Gerrit J. Poelarends, Barbro N. Melgert
Published 2021-06-01

Research highlights from the 2017 ERS International Congress: airway diseases in focus

by Cecilia Andersson, Sara J. Bonvini, Peter Horvath, Eduardo Marquez, Imran Satia, Paul Kirkham, Florence Schleich, Marco Idzko, Reinoud Gosens, Jose Luis Lopez-Campos, Apostolos Bossios, Omar Usmani, Antonio Spanevello, Ian M. Adcock, Alexander G. Mathioudakis
Published 2018-03-01