Selection on alleles affecting human longevity and late-life disease: the example of apolipoprotein E.

by Fotios Drenos, Thomas B L Kirkwood
Published 2010-04-01

Resolving the Enigma of the Clonal Expansion of mtDNA Deletions

by Axel Kowald, Thomas B.L. Kirkwood
Published 2018-02-01

Grip Strength Decline and Its Determinants in the Very Old: Longitudinal Findings from the Newcastle 85+ Study.

by Antoneta Granic, Karen Davies, Carol Jagger, Thomas B L Kirkwood, Holly E Syddall, Avan A Sayer
Published 2016-01-01

The contribution of diseases to the male-female disability-survival paradox in the very old: results from the Newcastle 85+ study.

by Andrew Kingston, Karen Davies, Joanna Collerton, Louise Robinson, Rachel Duncan, John Bond, Thomas B L Kirkwood, Carol Jagger
Published 2014-01-01

Deconstructing Complex Multimorbidity in the Very Old: Findings from the Newcastle 85+ Study

by Joanna Collerton, Carol Jagger, Mohammad E. Yadegarfar, Karen Davies, Stuart G. Parker, Louise Robinson, Thomas B. L. Kirkwood
Published 2016-01-01

Integrated Stochastic Model of DNA Damage Repair by Non-homologous End Joining and p53/p21-Mediated Early Senescence Signalling.

by David W P Dolan, Anze Zupanic, Glyn Nelson, Philip Hall, Satomi Miwa, Thomas B L Kirkwood, Daryl P Shanley
Published 2015-05-01

The personal and health service impact of falls in 85 year olds: cross-sectional findings from the Newcastle 85+ cohort study.

by Joanna Collerton, Andrew Kingston, John Bond, Karen Davies, Martin P Eccles, Carol Jagger, Thomas B L Kirkwood, Julia L Newton
Published 2012-01-01

Dynamic modelling of pathways to cellular senescence reveals strategies for targeted interventions.

by Piero Dalle Pezze, Glyn Nelson, Elsje G Otten, Viktor I Korolchuk, Thomas B L Kirkwood, Thomas von Zglinicki, Daryl P Shanley
Published 2014-08-01

Improving retention of very old participants in longitudinal research: experiences from the Newcastle 85+ study.

by Karen Davies, Andrew Kingston, Louise Robinson, Joan Hughes, Judith M Hunt, Sally A H Barker, June Edwards, Joanna Collerton, Carol Jagger, Thomas B L Kirkwood
Published 2014-01-01

Comparison of mitochondrial mutation spectra in ageing human colonic epithelium and disease: absence of evidence for purifying selection in somatic mitochondrial DNA point mutation...

by Laura C Greaves, Joanna L Elson, Marco Nooteboom, John P Grady, Geoffrey A Taylor, Robert W Taylor, John C Mathers, Thomas B L Kirkwood, Doug M Turnbull
Published 2012-01-01

Reactive oxygen species production and mitochondrial dysfunction in white blood cells are not valid biomarkers of ageing in the very old.

by Laura Wiley, Deepthi Ashok, Carmen Martin-Ruiz, Duncan C S Talbot, Joanna Collerton, Andrew Kingston, Karen Davies, Patrick F Chinnery, Michael Catt, Carol Jagger, Thomas B L Kirkwood, Thomas von Zglinicki
Published 2014-01-01

Predominant Asymmetrical Stem Cell Fate Outcome Limits the Rate of Niche Succession in Human Colonic Crypts

by Craig Stamp, Anze Zupanic, Ashwin Sachdeva, Elizabeth A. Stoll, Daryl P. Shanley, John C. Mathers, Thomas B.L. Kirkwood, Rakesh Heer, Benjamin D. Simons, Doug M. Turnbull, Laura C. Greaves
Published 2018-05-01

Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence.

by João F Passos, Gabriele Saretzki, Shaheda Ahmed, Glyn Nelson, Torsten Richter, Heiko Peters, Ilka Wappler, Matthew J Birket, Graham Harold, Karin Schaeuble, Mark A Birch-Machin, Thomas B L Kirkwood, Thomas von Zglinicki
Published 2007-05-01

Clonal expansion of early to mid-life mitochondrial DNA point mutations drives mitochondrial dysfunction during human ageing.

by Laura C Greaves, Marco Nooteboom, Joanna L Elson, Helen A L Tuppen, Geoffrey A Taylor, Daniel M Commane, Ramesh P Arasaradnam, Konstantin Khrapko, Robert W Taylor, Thomas B L Kirkwood, John C Mathers, Douglass M Turnbull
Published 2014-09-01

A meta-analysis of genome-wide association studies identifies multiple longevity genes

by Joris Deelen, Daniel S. Evans, Dan E. Arking, Niccolò Tesi, Marianne Nygaard, Xiaomin Liu, Mary K. Wojczynski, Mary L. Biggs, Ashley van der Spek, Gil Atzmon, Erin B. Ware, Chloé Sarnowski, Albert V. Smith, Ilkka Seppälä, Heather J. Cordell, Janina Dose, Najaf Amin, Alice M. Arnold, Kristin L. Ayers, Nir Barzilai, Elizabeth J. Becker, Marian Beekman, Hélène Blanché, Kaare Christensen, Lene Christiansen, Joanna C. Collerton, Sarah Cubaynes, Steven R. Cummings, Karen Davies, Birgit Debrabant, Jean-François Deleuze, Rachel Duncan, Jessica D. Faul, Claudio Franceschi, Pilar Galan, Vilmundur Gudnason, Tamara B. Harris, Martijn Huisman, Mikko A. Hurme, Carol Jagger, Iris Jansen, Marja Jylhä, Mika Kähönen, David Karasik, Sharon L. R. Kardia, Andrew Kingston, Thomas B. L. Kirkwood, Lenore J. Launer, Terho Lehtimäki, Wolfgang Lieb, Leo-Pekka Lyytikäinen, Carmen Martin-Ruiz, Junxia Min, Almut Nebel, Anne B. Newman, Chao Nie, Ellen A. Nohr, Eric S. Orwoll, Thomas T. Perls, Michael A. Province, Bruce M. Psaty, Olli T. Raitakari, Marcel J. T. Reinders, Jean-Marie Robine, Jerome I. Rotter, Paola Sebastiani, Jennifer Smith, Thorkild I. A. Sørensen, Kent D. Taylor, André G. Uitterlinden, Wiesje van der Flier, Sven J. van der Lee, Cornelia M. van Duijn, Diana van Heemst, James W. Vaupel, David Weir, Kenny Ye, Yi Zeng, Wanlin Zheng, Henne Holstege, Douglas P. Kiel, Kathryn L. Lunetta, P. Eline Slagboom, Joanne M. Murabito
Published 2019-08-01

Publisher Correction: A meta-analysis of genome-wide association studies identifies multiple longevity genes

by Joris Deelen, Daniel S. Evans, Dan E. Arking, Niccolò Tesi, Marianne Nygaard, Xiaomin Liu, Mary K. Wojczynski, Mary L. Biggs, Ashley van der Spek, Gil Atzmon, Erin B. Ware, Chloé Sarnowski, Albert V. Smith, Ilkka Seppälä, Heather J. Cordell, Janina Dose, Najaf Amin, Alice M. Arnold, Kristin L. Ayers, Nir Barzilai, Elizabeth J. Becker, Marian Beekman, Hélène Blanché, Kaare Christensen, Lene Christiansen, Joanna C. Collerton, Sarah Cubaynes, Steven R. Cummings, Karen Davies, Birgit Debrabant, Jean-François Deleuze, Rachel Duncan, Jessica D. Faul, Claudio Franceschi, Pilar Galan, Vilmundur Gudnason, Tamara B. Harris, Martijn Huisman, Mikko A. Hurme, Carol Jagger, Iris Jansen, Marja Jylhä, Mika Kähönen, David Karasik, Sharon L. R. Kardia, Andrew Kingston, Thomas B. L. Kirkwood, Lenore J. Launer, Terho Lehtimäki, Wolfgang Lieb, Leo-Pekka Lyytikäinen, Carmen Martin-Ruiz, Junxia Min, Almut Nebel, Anne B. Newman, Chao Nie, Ellen A. Nohr, Eric S. Orwoll, Thomas T. Perls, Michael A. Province, Bruce M. Psaty, Olli T. Raitakari, Marcel J. T. Reinders, Jean-Marie Robine, Jerome I. Rotter, Paola Sebastiani, Jennifer Smith, Thorkild I. A. Sørensen, Kent D. Taylor, André G. Uitterlinden, Wiesje van der Flier, Sven J. van der Lee, Cornelia M. van Duijn, Diana van Heemst, James W. Vaupel, David Weir, Kenny Ye, Yi Zeng, Wanlin Zheng, Henne Holstege, Douglas P. Kiel, Kathryn L. Lunetta, P. Eline Slagboom, Joanne M. Murabito
Published 2021-04-01