A novel decarboxylating amidohydrolase involved in avoiding metabolic dead ends during cyanuric acid catabolism in Pseudomonas sp. strain ADP.

by Lygie Esquirol, Thomas S Peat, Matthew Wilding, Carol J Hartley, Janet Newman, Colin Scott
Published 2018-01-01

X-Ray Structure and Mutagenesis Studies of the N-Isopropylammelide Isopropylaminohydrolase, AtzC.

by Sahil Balotra, Andrew C Warden, Janet Newman, Lyndall J Briggs, Colin Scott, Thomas S Peat
Published 2015-01-01

Determination of the structure of the catabolic N-succinylornithine transaminase (AstC) from Escherichia coli.

by Janet Newman, Shane Seabrook, Regina Surjadi, Charlotte C Williams, Del Lucent, Matthew Wilding, Colin Scott, Thomas S Peat
Published 2013-01-01

Structural and biochemical characterization of the biuret hydrolase (BiuH) from the cyanuric acid catabolism pathway of Rhizobium leguminasorum bv. viciae 3841.

by Lygie Esquirol, Thomas S Peat, Matthew Wilding, Del Lucent, Nigel G French, Carol J Hartley, Janet Newman, Colin Scott
Published 2018-01-01

Exploring the chemical space around 8-mercaptoguanine as a route to new inhibitors of the folate biosynthesis enzyme HPPK.

by Sandeep Chhabra, Nicholas Barlow, Olan Dolezal, Meghan K Hattarki, Janet Newman, Thomas S Peat, Bim Graham, James D Swarbrick
Published 2013-01-01

Structure-guided selection of puromycin N-acetyltransferase mutants with enhanced selection stringency for deriving mammalian cell lines expressing recombinant proteins

by Alessandro T. Caputo, Oliver M. Eder, Hana Bereznakova, Heleen Pothuis, Albert Ardevol, Janet Newman, Stewart Nuttall, Thomas S. Peat, Timothy E. Adams
Published 2021-03-01

Structure of S. aureus HPPK and the discovery of a new substrate site inhibitor.

by Sandeep Chhabra, Olan Dolezal, Brett M Collins, Janet Newman, Jamie S Simpson, Ian G Macreadie, Ross Fernley, Thomas S Peat, James D Swarbrick
Published 2012-01-01

The Glitazone Class of Drugs as Carbonic Anhydrase Inhibitors—A Spin-Off Discovery from Fragment Screening

by Sarah L. Mueller, Panagiotis K. Chrysanthopoulos, Maria A. Halili, Caryn Hepburn, Tom Nebl, Claudiu T. Supuran, Alessio Nocentini, Thomas S. Peat, Sally-Ann Poulsen
Published 2021-05-01

Fragment screening for a protein-protein interaction inhibitor to WDR5

by Matthew L. Dennis, Benjamin J. Morrow, Olan Dolezal, Anthony N. Cuzzupe, Alexandra E. Stupple, Janet Newman, John Bentley, Meghan Hattarki, Stewart D. Nuttall, Richard C. Foitzik, Ian P. Street, Paul A. Stupple, Brendon J. Monahan, Thomas. S. Peat
Published 2019-11-01

T-dependent B cell responses to Plasmodium induce antibodies that form a high-avidity multivalent complex with the circumsporozoite protein.

by Camilla R Fisher, Henry J Sutton, Joe A Kaczmarski, Hayley A McNamara, Ben Clifton, Joshua Mitchell, Yeping Cai, Johanna N Dups, Nicholas J D'Arcy, Mandeep Singh, Aaron Chuah, Thomas S Peat, Colin J Jackson, Ian A Cockburn
Published 2017-07-01

Correction: Small Molecule Inhibitors of the LEDGF Site of Human Immunodeficiency Virus Integrase Identified by Fragment Screening and Structure Based Design

by Thomas S. Peat, David I. Rhodes, Nick Vandegraaff, Giang Le, Jessica A. Smith, Lisa J. Clark, Eric D. Jones, Jonathan A. V. Coates, Neeranat Thienthong, Janet Newman, Olan Dolezal, Roger Mulder, John H. Ryan, G. Paul Savage, Craig L. Francis, John J. Deadman
Published 2013-01-01

Correction: Small Molecule Inhibitors of the LEDGF Site of Human Immunodeficiency Virus Integrase Identified by Fragment Screening and Structure Based Design.

by Thomas S. Peat, David I. Rhodes, Nick Vandegraaff, Giang Le, Jessica A. Smith, Lisa J. Clark, Eric D. Jones, Jonathan A. V. Coates, Neeranat Thienthong, Janet Newman, Olan Dolezal, Roger Mulder, John H. Ryan, G. Paul Savage, Craig L. Francis, John J. Deadman
Published 2013-01-01

Small molecule inhibitors of the LEDGF site of human immunodeficiency virus integrase identified by fragment screening and structure based design.

by Thomas S Peat, David I Rhodes, Nick Vandegraaff, Giang Le, Jessica A Smith, Lisa J Clark, Eric D Jones, Jonathan A V Coates, Neeranat Thienthong, Janet Newman, Olan Dolezal, Roger Mulder, John H Ryan, G Paul Savage, Craig L Francis, John J Deadman
Published 2012-01-01