Modulating Enzyme Function via Dynamic Allostery within Biliverdin Reductase B

by Jasmina S. Redzic, Michael R. Duff, Ashley Blue, Todd M. Pitts, Pratul Agarwal, Elan Zohar Eisenmesser
Published 2021-05-01

Utilization of quantitative in vivo pharmacology approaches to assess combination effects of everolimus and irinotecan in mouse xenograft models of colorectal cancer.

by Erica L Bradshaw-Pierce, Todd M Pitts, Gillian Kulikowski, Heather Selby, Andrea L Merz, Daniel L Gustafson, Natalie J Serkova, S Gail Eckhardt, Colin D Weekes
Published 2013-01-01

Efficacy and Molecular Mechanisms of Differentiated Response to the Aurora and Angiogenic Kinase Inhibitor ENMD-2076 in Preclinical Models of p53-Mutated Triple-Negative Breast Can...

by Anastasia A. Ionkina, John J. Tentler, Jihye Kim, Anna Capasso, Todd M. Pitts, Karen A. Ryall, Rebekah R. Howison, Peter Kabos, Carol A. Sartorius, Aik Choon Tan, S. Gail Eckhardt, Jennifer R. Diamond
Published 2017-05-01

Wee1 Inhibition Enhances the Anti-Tumor Effects of Capecitabine in Preclinical Models of Triple-Negative Breast Cancer

by Todd M. Pitts, Dennis M. Simmons, Stacey M. Bagby, Sarah J. Hartman, Betelehem W. Yacob, Brian Gittleman, John J. Tentler, Diana Cittelly, D. Ryan Ormond, Wells A. Messersmith, S. Gail Eckhardt, Jennifer R. Diamond
Published 2020-03-01

Evaluation of the efficacy of dasatinib, a Src/Abl inhibitor, in colorectal cancer cell lines and explant mouse model.

by Aaron J Scott, Eun-Kee Song, Stacey Bagby, Alicia Purkey, Martin McCarter, Csaba Gajdos, Kevin S Quackenbush, Benjamin Cross, Todd M Pitts, Aik Choon Tan, S Gail Eckhardt, Hubert Fenton, John Arcaroli, Wells A Messersmith
Published 2017-01-01

Combined inhibition of MEK and Aurora A kinase in KRAS/PIK3CA double-mutant colorectal cancer models

by S. Lindsey eDavis, S. Lindsey eDavis, Kelli M. Robertson, Todd M. Pitts, Todd M. Pitts, John J. Tentler, John J. Tentler, Erica L. Bradshaw-Pierce, Erica L. Bradshaw-Pierce, Erica L. Bradshaw-Pierce, Peter J. Klauck, Stacey M. Bagby, Stephanie L. Hyatt, Heather M. Selby, Anna eSpreafico, Jeffrey A Ecsedy, John J. Arcaroli, John J. Arcaroli, Wells A. Messersmith, Wells A. Messersmith, Aik Choon eTan, Aik Choon eTan, S. Gail eEckhardt, S. Gail eEckhardt
Published 2015-06-01

WEE1 Inhibition in Combination With Targeted Agents and Standard Chemotherapy in Preclinical Models of Pancreatic Ductal Adenocarcinoma

by Sarah J. Hartman, Stacey M. Bagby, Betelehem W. Yacob, Dennis M. Simmons, Morgan MacBeth, Christopher H. Lieu, S. Lindsey Davis, Alexis D. Leal, John J. Tentler, Jennifer R. Diamond, S. Gail Eckhardt, Wells A. Messersmith, Todd M. Pitts
Published 2021-03-01

RX-5902, a novel β-catenin modulator, potentiates the efficacy of immune checkpoint inhibitors in preclinical models of triple-negative breast Cancer

by John J. Tentler, Julie Lang, Anna Capasso, Deog Joong Kim, Ely Benaim, Young B. Lee, Andrew Eisen, Stacey M. Bagby, Sarah J. Hartman, Betelehem W. Yacob, Brian Gittleman, Todd M. Pitts, Roberta Pelanda, S. Gail Eckhardt, Jennifer R. Diamond
Published 2020-11-01

Dual pharmacological targeting of the MAP kinase and PI3K/mTOR pathway in preclinical models of colorectal cancer.

by Todd M Pitts, Timothy P Newton, Erica L Bradshaw-Pierce, Rebecca Addison, John J Arcaroli, Peter J Klauck, Stacey M Bagby, Stephanie L Hyatt, Alicia Purkey, John J Tentler, Aik Choon Tan, Wells A Messersmith, S Gail Eckhardt, Stephen Leong
Published 2014-01-01

Antitumor activity of the polo-like kinase inhibitor, TAK-960, against preclinical models of colorectal cancer

by Peter J. Klauck, Stacey M. Bagby, Anna Capasso, Erica L. Bradshaw-Pierce, Heather M. Selby, Anna Spreafico, John J. Tentler, Aik Choon Tan, Jihye Kim, John J. Arcaroli, Alicia Purkey, Wells A. Messersmith, Keisuke Kuida, S. Gail Eckhardt, Todd M. Pitts
Published 2018-02-01

Tumor p-glycoprotein correlates with efficacy of PF-3758309 in in vitro and in vivo models of colorectal cancer.

by Erica Lynn Bradshaw-Pierce, Erica Lynn Bradshaw-Pierce, Todd M Pitts, Aik-Choon eTan, Kelly eMcPhillips, Mark eWest, Daniel L Gustafson, Charles eHalsey, Leslie eNguyen, Nathan V Lee, Julie LC Kan, Brion William Murray, S. Gail eEckhardt
Published 2013-03-01

A phase II clinical trial of the Aurora and angiogenic kinase inhibitor ENMD-2076 for previously treated, advanced, or metastatic triple-negative breast cancer

by Jennifer R. Diamond, S. G. Eckhardt, Todd M. Pitts, Adrie van Bokhoven, Dara Aisner, Daniel L. Gustafson, Anna Capasso, Sharon Sams, Peter Kabos, Kathryn Zolman, Tiffany Colvin, Anthony D. Elias, Anna M. Storniolo, Bryan P. Schneider, Dexiang Gao, John J. Tentler, Virginia F. Borges, Kathy D. Miller
Published 2018-08-01

Association of the Epithelial-to-Mesenchymal Transition (EMT) Phenotype with Responsiveness to the p21-Activated Kinase Inhibitor, PF-3758309, in Colon Cancer Models

by Todd M Pitts, Gillian N Kulikowski, Aik-Choon eTan, Brion William Murray, John J Arcaroli, John J Tentler, Anna eSpreafico, Heather M Selby, Maria I Kachaeva, Kelly L McPhillips, Blair C Britt, Erica Lynn Bradshaw-Pierce, Erica Lynn Bradshaw-Pierce, Wells A Messersmith, Marileila eVarella-Garcia, S. Gail eEckhardt
Published 2013-03-01

Testing Cancer Immunotherapy in a Human Immune System Mouse Model: Correlating Treatment Responses to Human Chimerism, Therapeutic Variables and Immune Cell Phenotypes

by Juan A. Marín-Jiménez, Anna Capasso, Matthew S. Lewis, Stacey M. Bagby, Sarah J. Hartman, Jeremy Shulman, Natalie M. Navarro, Hui Yu, Hui Yu, Chris J. Rivard, Chris J. Rivard, Xiaoguang Wang, Jessica C. Barkow, Degui Geng, Adwitiya Kar, Ashley Yingst, Dejene M. Tufa, James T. Dolan, Patrick J. Blatchford, Brian M. Freed, Brian M. Freed, Raul M. Torres, Raul M. Torres, Eduardo Davila, Eduardo Davila, Jill E. Slansky, Jill E. Slansky, Roberta Pelanda, Roberta Pelanda, S. Gail Eckhardt, Wells A. Messersmith, Wells A. Messersmith, Jennifer R. Diamond, Jennifer R. Diamond, Christopher H. Lieu, Michael R. Verneris, Jing H. Wang, Jing H. Wang, Katja Kiseljak-Vassiliades, Katja Kiseljak-Vassiliades, Todd M. Pitts, Todd M. Pitts, Julie Lang
Published 2021-03-01