An Ash2L/RbBP5 heterodimer stimulates the MLL1 methyltransferase activity through coordinated substrate interactions with the MLL1 SET domain.

by Fang Cao, Yong Chen, Tomasz Cierpicki, Yifan Liu, Venkatesha Basrur, Ming Lei, Yali Dou
Published 2010-11-01

An evolution-based approach to De Novo protein design and case study on Mycobacterium tuberculosis.

by Pralay Mitra, David Shultis, Jeffrey R Brender, Jeff Czajka, David Marsh, Felicia Gray, Tomasz Cierpicki, Yang Zhang
Published 2013-10-01

BMI1 regulates PRC1 architecture and activity through homo- and hetero-oligomerization

by Felicia Gray, Hyo Je Cho, Shirish Shukla, Shihan He, Ashley Harris, Bohdan Boytsov, Łukasz Jaremko, Mariusz Jaremko, Borries Demeler, Elizabeth R. Lawlor, Jolanta Grembecka, Tomasz Cierpicki
Published 2016-11-01

Cytokine induced phenotypic and epigenetic signatures are key to establishing specific macrophage phenotypes.

by Nicolai A Kittan, Ronald M Allen, Abhay Dhaliwal, Karen A Cavassani, Matthew Schaller, Katherine A Gallagher, William F Carson, Sumanta Mukherjee, Jolanta Grembecka, Tomasz Cierpicki, Gabor Jarai, John Westwick, Steven L Kunkel, Cory M Hogaboam
Published 2013-01-01

Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity

by David S. Rogawski, Jing Deng, Hao Li, Hongzhi Miao, Dmitry Borkin, Trupta Purohit, Jiho Song, Jennifer Chase, Shuangjiang Li, Juliano Ndoj, Szymon Klossowski, EunGi Kim, Fengbiao Mao, Bo Zhou, James Ropa, Marta Z. Krotoska, Zhuang Jin, Patricia Ernst, Xiaomin Feng, Gang Huang, Kenichi Nishioka, Samantha Kelly, Miao He, Bo Wen, Duxin Sun, Andrew Muntean, Yali Dou, Ivan Maillard, Tomasz Cierpicki, Jolanta Grembecka
Published 2021-05-01