Evaluation of tumor immune contexture among intrinsic molecular subtypes helps to predict outcome in early breast cancer

by Valentin Derangere, Quentin Klopfenstein, Marion Thibaudin, Laurent Arnould, Sylvain Ladoire
Published 2021-06-01

Cathepsin B Is Required for NLRP3 Inflammasome Activation in Macrophages, Through NLRP3 Interaction

by Angélique Chevriaux, Angélique Chevriaux, Thomas Pilot, Thomas Pilot, Valentin Derangère, Valentin Derangère, Valentin Derangère, Harmonie Simonin, Harmonie Simonin, Pierre Martine, Pierre Martine, Fanny Chalmin, François Ghiringhelli, François Ghiringhelli, François Ghiringhelli, Cédric Rébé, Cédric Rébé, Cédric Rébé
Published 2020-03-01

Nitric Oxide-Releasing Drug Glyceryl Trinitrate Targets JAK2/STAT3 Signaling, Migration and Invasion of Triple-Negative Breast Cancer Cells

by Sarra Bouaouiche, Silvia Ghione, Randa Sghaier, Olivier Burgy, Cindy Racoeur, Valentin Derangère, Ali Bettaieb, Stéphanie Plenchette
Published 2021-08-01

Radiotherapy Scheme Effect on PD-L1 Expression for Locally Advanced Rectal Cancer

by Jihane Boustani, Valentin Derangère, Aurélie Bertaut, Olivier Adotevi, Véronique Morgand, Céline Charon-Barra, François Ghiringhelli, Céline Mirjolet
Published 2020-09-01

Prognostic value of Thyroid Transcription Factor-1 expression in lung adenocarcinoma in patients treated with anti PD-1/PD-L1

by Loïck Galland, Anne Laure Le Page, Julie Lecuelle, Frederic Bibeau, Youssef Oulkhouir, Valentin Derangère, Caroline Truntzer, François Ghiringhelli
Published 2021-01-01

Tracking the evolution of circulating exosomal-PD-L1 to monitor melanoma patients

by Marine Cordonnier, Charlée Nardin, Gaëtan Chanteloup, Valentin Derangere, Marie-Paule Algros, Laurent Arnould, Carmen Garrido, François Aubin, Jessica Gobbo
Published 2020-01-01

RAS status and neoadjuvant chemotherapy impact CD8+ cells and tumor HLA class I expression in liver metastatic colorectal cancer

by Fanny Ledys, Quentin Klopfenstein, Caroline Truntzer, Laurent Arnould, Julie Vincent, Leila Bengrine, Romain Remark, Romain Boidot, Sylvain Ladoire, Francois Ghiringhelli, Valentin Derangere
Published 2018-11-01

Bleomycin exerts ambivalent antitumor immune effect by triggering both immunogenic cell death and proliferation of regulatory T cells.

by Hélène Bugaut, Mélanie Bruchard, Hélène Berger, Valentin Derangère, Ludivine Odoul, Romain Euvrard, Sylvain Ladoire, Fanny Chalmin, Frédérique Végran, Cédric Rébé, Lionel Apetoh, François Ghiringhelli, Grégoire Mignot
Published 2013-01-01

Fluorouracil and bevacizumab plus anakinra for patients with metastatic colorectal cancer refractory to standard therapies (IRAFU): a single-arm phase 2 study

by Nicolas Isambert, Alice Hervieu, Cedric Rébé, Audrey Hennequin, Christophe Borg, Sylvie Zanetta, Angélique Chevriaux, Corentin Richard, Valentin Derangère, Emeric Limagne, Julie Blanc, Aurélie Bertaut, François Ghiringhelli
Published 2018-09-01

TCR Clonality and Genomic Instability Signatures as Prognostic Biomarkers in High Grade Serous Ovarian Cancer

by Julie Lecuelle, Romain Boidot, Hugo Mananet, Valentin Derangère, Juliette Albuisson, Vincent Goussot, Laurent Arnould, Zoé Tharin, Isabelle Ray Coquard, François Ghiringhelli, Caroline Truntzer, Jean-David Fumet
Published 2021-08-01

Immune classifications with cytotoxic CD8+ and Th17 infiltrates are predictors of clinical prognosis in glioblastoma

by Rachid Madkouri, Coureche Guillaume Kaderbhai, Aurélie Bertaut, Caroline Truntzer, Julie Vincent, Marie Hélene Aubriot-Lorton, Walid Farah, Emeric Limagne, Sylvain Ladoire, Romain Boidot, Valentin Derangère, François Ghiringhelli
Published 2017-06-01

Lysophosphatidylcholine acyltransferase 2-mediated lipid droplet production supports colorectal cancer chemoresistance

by Alexia Karen Cotte, Virginie Aires, Maxime Fredon, Emeric Limagne, Valentin Derangère, Marion Thibaudin, Etienne Humblin, Alessandra Scagliarini, Jean-Paul Pais de Barros, Patrick Hillon, François Ghiringhelli, Dominique Delmas
Published 2018-01-01

Optimized fractionated radiotherapy with anti-PD-L1 and anti-TIGIT: a promising new combination

by Mathieu Grapin, Corentin Richard, Emeric Limagne, Romain Boidot, Véronique Morgand, Aurélie Bertaut, Valentin Derangere, Pierre-Antoine Laurent, Marion Thibaudin, Jean David Fumet, Gilles Crehange, François Ghiringhelli, Céline Mirjolet
Published 2019-06-01

Sirtuin-1 Activation Controls Tumor Growth by Impeding Th17 Differentiation via STAT3 Deacetylation

by Emeric Limagne, Marion Thibaudin, Romain Euvrard, Hélène Berger, Pauline Chalons, Frédérique Végan, Etienne Humblin, Romain Boidot, Cédric Rébé, Valentin Derangère, Sylvain Ladoire, Lionel Apetoh, Dominique Delmas, François Ghiringhelli
Published 2017-04-01

IRF8-dependent molecular complexes control the Th9 transcriptional program

by Etienne Humblin, Marion Thibaudin, Fanny Chalmin, Valentin Derangère, Emeric Limagne, Corentin Richard, Richard A. Flavell, Sandy Chevrier, Sylvain Ladoire, Hélène Berger, Romain Boidot, Lionel Apetoh, Frédérique Végran, François Ghiringhelli
Published 2017-12-01

Follicular helper-T cells restore CD8+-dependent antitumor immunity and anti-PD-L1/PD-1 efficacy

by Valentin Derangere, Marion Thibaudin, Fanny Chalmin, Cédric Rébé, Julie Niogret, Hélène Berger, Romain Mary, Elise Ballot, Christophe Hibos, Léa Hampe, David Rageot, Théo Accogli, Philippe Joubert, James Harker, Frederique Vegran
Published 2021-06-01

Interplay between Liver X Receptor and Hypoxia Inducible Factor 1α Potentiates Interleukin-1β Production in Human Macrophages

by Louise Ménégaut, Charles Thomas, Antoine Jalil, Jean Baptiste Julla, Charlène Magnani, Adam Ceroi, Louise Basmaciyan, Adélie Dumont, Wilfried Le Goff, Mano Joseph Mathew, Cédric Rébé, Valentin Dérangère, Aline Laubriet, Valentin Crespy, Jean-Paul Pais de Barros, Eric Steinmetz, Nicolas Venteclef, Philippe Saas, Laurent Lagrost, David Masson
Published 2020-05-01