Affibody Molecules as Targeting Vectors for PET Imaging

by Vladimir Tolmachev, Anna Orlova
Published 2020-03-01

PET and SPECT Imaging of the EGFR Family (RTK Class I) in Oncology

by Sara S. Rinne, Anna Orlova, Vladimir Tolmachev
Published 2021-04-01

Imaging using radiolabelled targeted proteins: radioimmunodetection and beyond

by Javad Garousi, Anna Orlova, Fredrik Y. Frejd, Vladimir Tolmachev
Published 2020-06-01

66Ga-PET-imaging of GRPR-expression in prostate cancer: production and characterization of [66Ga]Ga-NOTA-PEG2-RM26

by Sara S. Rinne, Ayman Abouzayed, Katherine Gagnon, Vladimir Tolmachev, Anna Orlova
Published 2021-02-01

One-Dimensional Multi-Channel Photonic Crystal Resonators Based on Silicon-On-Insulator With High Quality Factor

by Joaquin Faneca, Joaquin Faneca, Tatiana S. Perova, Tatiana S. Perova, Vladimir Tolmachev, Anna Baldycheva
Published 2018-05-01

Preclinical Evaluation of ^99mTc-Labeled GRPR Antagonists maSSS/SES-PEG₂-RM26 for Imaging of Prostate Cancer

by Ayman Abouzayed, Sara S. Rinne, Hamideh Sabahnoo, Jens Sörensen, Vladimir Chernov, Vladimir Tolmachev, Anna Orlova
Published 2021-01-01

Drug Conjugates Based on a Monovalent Affibody Targeting Vector Can Efficiently Eradicate HER2 Positive Human Tumors in an Experimental Mouse Model

by Tianqi Xu, Haozhong Ding, Anzhelika Vorobyeva, Maryam Oroujeni, Anna Orlova, Vladimir Tolmachev, Torbjörn Gräslund
Published 2021-12-01

Incorporation of a Hydrophilic Spacer Reduces Hepatic Uptake of HER2-Targeting Affibody–DM1 Drug Conjugates

by Haozhong Ding, Mohamed Altai, Sara S. Rinne, Anzhelika Vorobyeva, Vladimir Tolmachev, Torbjörn Gräslund, Anna Orlova
Published 2019-08-01

Evaluation of Tumor-Targeting Properties of an Antagonistic Bombesin Analogue RM26 Conjugated with a Non-Residualizing Radioiodine Label Comparison with a Radiometal-Labelled Count...

by Maryam Oroujeni, Ayman Abouzayed, Fanny Lundmark, Bogdan Mitran, Anna Orlova, Vladimir Tolmachev, Ulrika Rosenström
Published 2019-08-01

Indirect Radioiodination of DARPin G3 Using N-succinimidyl-<i>Para</i>-Iodobenzoate Improves the Contrast of HER2 Molecular Imaging

by Anzhelika Vorobyeva, Alexey Schulga, Sara S. Rinne, Tyran Günther, Anna Orlova, Sergey Deyev, Vladimir Tolmachev
Published 2019-06-01

Preclinical Evaluation of [68Ga]Ga-DFO-ZEGFR:2377: A Promising Affibody-Based Probe for Noninvasive PET Imaging of EGFR Expression in Tumors

by Maryam Oroujeni, Javad Garousi, Ken G. Andersson, John Löfblom, Bogdan Mitran, Anna Orlova, Vladimir Tolmachev
Published 2018-09-01

High Contrast PET Imaging of GRPR Expression in Prostate Cancer Using Cobalt-Labeled Bombesin Antagonist RM26

by Bogdan Mitran, Helge Thisgaard, Ulrika Rosenström, Johan Hygum Dam, Mats Larhed, Vladimir Tolmachev, Anna Orlova
Published 2017-01-01

Influence of macrocyclic chelators on the targeting properties of (68)Ga-labeled synthetic affibody molecules: comparison with (111)In-labeled counterparts.

by Joanna Strand, Hadis Honarvar, Anna Perols, Anna Orlova, Ram Kumar Selvaraju, Amelie Eriksson Karlström, Vladimir Tolmachev
Published 2013-01-01

Position for Site-Specific Attachment of a DOTA Chelator to Synthetic Affibody Molecules Has a Different Influence on the Targeting Properties of Ga-Compared to In-Labeled Conjugat...

by Hadis Honarvar, Joanna Strand, Anna Perols, Anna Orlova, Ram Kumar Selvaraju, Amelie Eriksson Karlström, Vladimir Tolmachev
Published 2014-12-01

Affibody-Derived Drug Conjugates Targeting HER2: Effect of Drug Load on Cytotoxicity and Biodistribution

by Haozhong Ding, Tianqi Xu, Jie Zhang, Vladimir Tolmachev, Maryam Oroujeni, Anna Orlova, Torbjörn Gräslund, Anzhelika Vorobyeva
Published 2021-03-01

Kinetic analysis of HER2-binding ABY-025 Affibody molecule using dynamic PET in patients with metastatic breast cancer

by Ali Alhuseinalkhudhur, Mark Lubberink, Henrik Lindman, Vladimir Tolmachev, Fredrik Y. Frejd, Joachim Feldwisch, Irina Velikyan, Jens Sörensen
Published 2020-03-01

Influence of Residualizing Properties of the Radiolabel on Radionuclide Molecular Imaging of HER3 Using Affibody Molecules

by Sara S. Rinne, Tianqi Xu, Charles Dahlsson Leitao, Stefan Ståhl, John Löfblom, Anna Orlova, Vladimir Tolmachev, Anzhelika Vorobyeva
Published 2020-02-01

Synthesis and Preclinical Evaluation of Radio-Iodinated GRPR/PSMA Bispecific Heterodimers for the Theranostics Application in Prostate Cancer

by Ayman Abouzayed, Cheng-Bin Yim, Bogdan Mitran, Sara S. Rinne, Vladimir Tolmachev, Mats Larhed, Ulrika Rosenström, Anna Orlova
Published 2019-07-01

Heterodimeric Radiotracer Targeting PSMA and GRPR for Imaging of Prostate Cancer—Optimization of the Affinity towards PSMA by Linker Modification in Murine Model

by Fanny Lundmark, Ayman Abouzayed, Bogdan Mitran, Sara S. Rinne, Zohreh Varasteh, Mats Larhed, Vladimir Tolmachev, Ulrika Rosenström, Anna Orlova
Published 2020-07-01

Preclinical Evaluation of the Copper-64 Labeled GRPR-Antagonist RM26 in Comparison with the Cobalt-55 Labeled Counterpart for PET-Imaging of Prostate Cancer

by Christina Baun, Bogdan Mitran, Sara S. Rinne, Johan H. Dam, Birgitte B. Olsen, Vladimir Tolmachev, Anna Orlova, Helge Thisgaard
Published 2020-12-01