Selective Induction of Cancer Cell Death by Targeted Granzyme B

by Robert A. Jabulowsky, Pranav Oberoi, Winfried S. Wels
Published 2013-02-01

Chimeric Antigen Receptor-Engineered NK-92 Cells: An Off-the-Shelf Cellular Therapeutic for Targeted Elimination of Cancer Cells and Induction of Protective Antitumor Immunity

by Congcong Zhang, Congcong Zhang, Congcong Zhang, Pranav Oberoi, Sarah Oelsner, Anja Waldmann, Aline Lindner, Torsten Tonn, Torsten Tonn, Torsten Tonn, Torsten Tonn, Winfried S. Wels, Winfried S. Wels, Winfried S. Wels
Published 2017-05-01

EGFR-targeted granzyme B expressed in NK cells enhances natural cytotoxicity and mediates specific killing of tumor cells.

by Pranav Oberoi, Robert A Jabulowsky, Hayat Bähr-Mahmud, Winfried S Wels
Published 2013-01-01

Maltose-binding protein enhances secretion of recombinant human granzyme B accompanied by in vivo processing of a precursor MBP fusion protein.

by Benjamin Dälken, Robert A Jabulowsky, Pranav Oberoi, Itai Benhar, Winfried S Wels
Published 2010-12-01

Directed Differentiation of Mobilized Hematopoietic Stem and Progenitor Cells into Functional NK Cells with Enhanced Antitumor Activity

by Pranav Oberoi, Kathrina Kamenjarin, Jose Francisco Villena Ossa, Barbara Uherek, Halvard Bönig, Winfried S. Wels
Published 2020-03-01

ERBB2-CAR-Engineered Cytokine-Induced Killer Cells Exhibit Both CAR-Mediated and Innate Immunity Against High-Risk Rhabdomyosarcoma

by Michael Merker, Michael Merker, Michael Merker, Juliane Wagner, Hermann Kreyenberg, Catrin Heim, Laura M. Moser, Winfried S. Wels, Winfried S. Wels, Winfried S. Wels, Halvard Bonig, Halvard Bonig, Zoltán Ivics, Evelyn Ullrich, Evelyn Ullrich, Evelyn Ullrich, Thomas Klingebiel, Thomas Klingebiel, Thomas Klingebiel, Peter Bader, Peter Bader, Peter Bader, Eva Rettinger, Eva Rettinger, Eva Rettinger
Published 2020-10-01

High Cytotoxic Efficiency of Lentivirally and Alpharetrovirally Engineered CD19-Specific Chimeric Antigen Receptor Natural Killer Cells Against Acute Lymphoblastic Leukemia

by Stephan Müller, Stephan Müller, Tobias Bexte, Tobias Bexte, Tobias Bexte, Veronika Gebel, Veronika Gebel, Franziska Kalensee, Franziska Kalensee, Eva Stolzenberg, Eva Stolzenberg, Jessica Hartmann, Ulrike Koehl, Ulrike Koehl, Ulrike Koehl, Axel Schambach, Axel Schambach, Winfried S. Wels, Winfried S. Wels, Winfried S. Wels, Ute Modlich, Evelyn Ullrich, Evelyn Ullrich, Evelyn Ullrich, Evelyn Ullrich
Published 2020-01-01

CAR-Engineered NK Cells for the Treatment of Glioblastoma: Turning Innate Effectors Into Precision Tools for Cancer Immunotherapy

by Michael C. Burger, Michael C. Burger, Michael C. Burger, Michael C. Burger, Congcong Zhang, Congcong Zhang, Congcong Zhang, Patrick N. Harter, Patrick N. Harter, Patrick N. Harter, Patrick N. Harter, Annette Romanski, Florian Strassheimer, Florian Strassheimer, Christian Senft, Christian Senft, Christian Senft, Torsten Tonn, Torsten Tonn, Torsten Tonn, Torsten Tonn, Joachim P. Steinbach, Joachim P. Steinbach, Joachim P. Steinbach, Joachim P. Steinbach, Winfried S. Wels, Winfried S. Wels, Winfried S. Wels, Winfried S. Wels
Published 2019-11-01

Vaccination directed against the human endogenous retrovirus-K envelope protein inhibits tumor growth in a murine model system.

by Benjamin Kraus, Katrin Fischer, Sarah M Büchner, Winfried S Wels, Roswitha Löwer, Katja Sliva, Barbara S Schnierle
Published 2013-01-01

A Two-Phase Expansion Protocol Combining Interleukin (IL)-15 and IL-21 Improves Natural Killer Cell Proliferation and Cytotoxicity against Rhabdomyosarcoma

by Juliane Wagner, Juliane Wagner, Juliane Wagner, Viktoria Pfannenstiel, Viktoria Pfannenstiel, Viktoria Pfannenstiel, Anja Waldmann, Judith W. J. Bergs, Judith W. J. Bergs, Judith W. J. Bergs, Boris Brill, Sabine Huenecke, Sabine Huenecke, Thomas Klingebiel, Franz Rödel, Franz Rödel, Franz Rödel, Christian J. Buchholz, Christian J. Buchholz, Christian J. Buchholz, Winfried S. Wels, Winfried S. Wels, Winfried S. Wels, Peter Bader, Peter Bader, Evelyn Ullrich, Evelyn Ullrich, Evelyn Ullrich
Published 2017-06-01

Expression of Potential Targets for Cell-Based Therapies on Melanoma Cells

by Sophia B. Strobel, Devayani Machiraju, Ingrid Hülsmeyer, Jürgen C. Becker, Annette Paschen, Dirk Jäger, Winfried S. Wels, Michael Bachmann, Jessica C. Hassel
Published 2021-03-01

Retargeting of NK-92 Cells against High-Risk Rhabdomyosarcomas by Means of an ERBB2 (HER2/Neu)-Specific Chimeric Antigen Receptor

by Leonie D. H. Gossel, Catrin Heim, Lisa-Marie Pfeffermann, Laura M. Moser, Halvard B. Bönig, Thomas E. Klingebiel, Peter Bader, Winfried S. Wels, Michael Merker, Eva Rettinger
Published 2021-03-01

In vivo generation of human CD19‐CAR T cells results in B‐cell depletion and signs of cytokine release syndrome

by Anett Pfeiffer, Frederic B Thalheimer, Sylvia Hartmann, Annika M Frank, Ruben R Bender, Simon Danisch, Caroline Costa, Winfried S Wels, Ute Modlich, Renata Stripecke, Els Verhoeyen, Christian J Buchholz
Published 2018-11-01

Optical Imaging of Cellular Immunotherapy against Prostate Cancer

by Sidhartha Tavri, Priyanka Jha, Reinhard Meier, Tobias D. Henning, Tina Müller, Daniel Hostetter, Christiane Knopp, Magnus Johansson, Verena Reinhart, Sophie Boddington, Akhilesh Sista, Winfried S. Wels, Heike E. Daldrup-Link
Published 2009-01-01

Advantages and Applications of CAR-Expressing Natural Killer Cells

by Wolfgang eGlienke, Ruth eEsser, Christoph ePriesner, Julia eSuerth, Axel eSchambach, Winfried eWels, Manuel eGrez, Stephan eKloess, Lubomir eArseniev, Ulrike eKoehl
Published 2015-02-01

TanCAR: A Novel Bispecific Chimeric Antigen Receptor for Cancer Immunotherapy

by Zakaria Grada, Meenakshi Hegde, Tiara Byrd, Donald R Shaffer, Alexia Ghazi, Vita S Brawley, Amanda Corder, Kurt Schönfeld, Joachim Koch, Gianpietro Dotti, Helen E Heslop, Stephen Gottschalk, Winfried S Wels, Matthew L Baker, Nabil Ahmed
Published 2013-01-01

Cytotoxic capacity of IL-15-stimulated cytokine-induced killer cells against human acute myeloid leukemia and rhabdomyosarcoma in humanized preclinical mouse models

by Eva eRettinger, Vida eMeyer, Hermann eKreyenberg, Andreas eVolk, Selim eKuci, Andre eWillasch, Ewa eKoscielniak, Simone eFulda, Winfried eWels, Halvard eBoenig, Thomas eKlingebiel, Peter eBader
Published 2012-04-01

Tailoring cells for clinical needs: Meeting report from the Advanced Therapy in Healthcare symposium (October 28–29 2017, Doha, Qatar)

by Sara Deola, Bella S. Guerrouahen, Heba Sidahmed, Anjud Al-Mohannadi, Muhammad Elnaggar, Ramaz Elsadig, Essam M. Abdelalim, Goran Petrovski, Massimo Gadina, Adrian Thrasher, Winfried S. Wels, Stephen P. Hunger, Ena Wang, Francesco M. Marincola, ATH Consortium, Cristina Maccalli, Chiara Cugno
Published 2018-10-01

Tumor response and endogenous immune reactivity after administration of HER2 CAR T cells in a child with metastatic rhabdomyosarcoma

by Meenakshi Hegde, Sujith K. Joseph, Farzana Pashankar, Christopher DeRenzo, Khaled Sanber, Shoba Navai, Tiara T. Byrd, John Hicks, Mina L. Xu, Claudia Gerken, Mamta Kalra, Catherine Robertson, Huimin Zhang, Ankita Shree, Birju Mehta, Olga Dakhova, Vita S. Salsman, Bambi Grilley, Adrian Gee, Gianpietro Dotti, Helen E. Heslop, Malcolm K. Brenner, Winfried S. Wels, Stephen Gottschalk, Nabil Ahmed
Published 2020-07-01