CRISPR-Mediated Base Conversion Allows Discriminatory Depletion of Endogenous T Cell Receptors for Enhanced Synthetic Immunity

CRISPR-Mediated Base Conversion Allows Discriminatory Depletion of Endogenous T Cell Receptors for Enhanced Synthetic Immunity

Emerging base editing technology exploits CRISPR RNA-guided DNA modification effects for highly specific C > T conversion, which has been used to efficiently disrupt gene expression. These tools can enhance synthetic T cell immunity by restricting specificity, addressing histocompatibility leukoc...

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Bibliographic Details
Main Authors: Roland Preece, Andrea Pavesi, Soragia Athina Gkazi, Kerstin A. Stegmann, Christos Georgiadis, Zhi Ming Tan, Jia Ying Joey Aw, Mala K. Maini, Antonio Bertoletti, Waseem Qasim
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
CRISPR/Cas9Base editing
Recombinant TCR
Gene therapy
Cell therapy
Hepatocellular carcinoma (HCC)
Hepatitis B virus (HBV)
Online Access:http://www.sciencedirect.com/science/article/pii/S232905012030187X

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http://www.sciencedirect.com/science/article/pii/S232905012030187X

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