RanBP3 Regulates Proliferation, Apoptosis and Chemosensitivity of Chronic Myeloid Leukemia Cells via Mediating SMAD2/3 and ERK1/2 Nuclear Transport

RanBP3 Regulates Proliferation, Apoptosis and Chemosensitivity of Chronic Myeloid Leukemia Cells via Mediating SMAD2/3 and ERK1/2 Nuclear Transport

Abnormal subcellular localization of proteins is an important cause of tumorigenesis and drug resistance. Chromosome region maintenance 1 (CRM1), the nuclear export regulator of most proteins, has been confirmed to be over-expressed in various malignancies and is regarded as an efficient target. But...

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Bibliographic Details
Main Authors: Qian Li, Zhenglan Huang, Yuhang Peng, Xin Wang, Guoyun Jiang, Teng Wang, Ke Mou, Wenli Feng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Oncology
Subjects:
RanBP3
nuclear export
CML
imatinib
ERK1/2
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.698410/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.698410/full

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