Characterization and identification of candiduria due to Candida species in diabetic patients
Background and Purpose: The presence of Candida yeasts in urine, known as candiduria, is an indicator of infection or colonization of the urinary tract by Candida species. This condition in diabetic patients can be hazardous due to diminished immune system response. The objective of this study was t...
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doaj-0161ba1b36554ebcb77295078ea871112020-11-24T21:47:48ZengMazandaran University of Medical SciencesCurrent Medical Mycology2423-34392423-34202016-09-01231014Characterization and identification of candiduria due to Candida species in diabetic patientsMehraban Falahati0Shirin Farahyar1Lame Akhlaghi2Shahram Mahmoudi3Kamran Sabzian4Mohamad Yarahmadi5Reza Aslani6 Department of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Department of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Department of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran ???, Lorestan University of Medical Sciences, Khorramabad, Iran Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Department of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Background and Purpose: The presence of Candida yeasts in urine, known as candiduria, is an indicator of infection or colonization of the urinary tract by Candida species. This condition in diabetic patients can be hazardous due to diminished immune system response. The objective of this study was to investigate the incidence of candiduria in diabetic patients and to identify its causative agents. Furthermore, the demographic and laboratory (HbA1c, urine glucose and pH, urine culture colony count, and fasting blood sugar) data and their possible associations with candiduria were investigated. Materials and Methods: This cross-sectional, descriptive study was performed on 305 diabetic patients referred to the diabetes research center, Hamedan, Iran, during April 2015 to September 2015. Urine and blood specimens were collected and urine analysis, urine culture, FBS, and HbA1c tests were performed. Positive cases were subjected to colony count and the causative agents were subsequently identified through the routine identification tests, as well as colony color in CHROMagar Candida medium, and the assimilation patterns in API 20 C auxanographic method. Results: Among the 305 cases, 38 (%12.5) were positive for candiduria. Causative agents were identified as Candida glabrata (n=19, 50%), C. albicans (n=12, 31.6%), C. krusei (n=4, 10.5%), C. tropicalis (n=2, 5.3%), and C. kefyr (n=1, 2.6%). According to the results of the statistical analyses, there were significant association between candiduria and female gender, high FBS and urine glucose, uncontrolled diabetes (HbA1c ≥8), and acidic urine pH (P<0.05). Conclusion: Considering the high incidence rate of candiduria in diabetic patients, control of diabetes, predisposing factors, and causal relationships between diabetes and candiduria should be highlighted.http://cmm.mazums.ac.ir/browse.php?a_code=A-10-88-1&slc_lang=en&sid=1Candida Diabetes HbA1c Urinary tract infections |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mehraban Falahati Shirin Farahyar Lame Akhlaghi Shahram Mahmoudi Kamran Sabzian Mohamad Yarahmadi Reza Aslani |
spellingShingle |
Mehraban Falahati Shirin Farahyar Lame Akhlaghi Shahram Mahmoudi Kamran Sabzian Mohamad Yarahmadi Reza Aslani Characterization and identification of candiduria due to Candida species in diabetic patients Current Medical Mycology Candida Diabetes HbA1c Urinary tract infections |
author_facet |
Mehraban Falahati Shirin Farahyar Lame Akhlaghi Shahram Mahmoudi Kamran Sabzian Mohamad Yarahmadi Reza Aslani |
author_sort |
Mehraban Falahati |
title |
Characterization and identification of candiduria due to Candida species in
diabetic patients |
title_short |
Characterization and identification of candiduria due to Candida species in
diabetic patients |
title_full |
Characterization and identification of candiduria due to Candida species in
diabetic patients |
title_fullStr |
Characterization and identification of candiduria due to Candida species in
diabetic patients |
title_full_unstemmed |
Characterization and identification of candiduria due to Candida species in
diabetic patients |
title_sort |
characterization and identification of candiduria due to candida species in
diabetic patients |
publisher |
Mazandaran University of Medical Sciences |
series |
Current Medical Mycology |
issn |
2423-3439 2423-3420 |
publishDate |
2016-09-01 |
description |
Background and Purpose: The presence of Candida yeasts in urine, known as candiduria, is an indicator of infection or colonization of the urinary tract by Candida species. This condition in diabetic patients can be hazardous due to diminished immune system response. The objective of this study was to investigate the incidence of candiduria in diabetic patients and to identify its causative agents. Furthermore, the demographic and laboratory (HbA1c, urine glucose and pH, urine culture colony count, and fasting blood sugar) data and their possible associations with candiduria were investigated.
Materials and Methods: This cross-sectional, descriptive study was performed on 305 diabetic patients referred to
the diabetes research center, Hamedan, Iran, during April 2015 to September 2015. Urine and blood specimens were
collected and urine analysis, urine culture, FBS, and HbA1c tests were performed. Positive cases were subjected to
colony count and the causative agents were subsequently identified through the routine identification tests, as well as
colony color in CHROMagar Candida medium, and the assimilation patterns in API 20 C auxanographic method.
Results: Among the 305 cases, 38 (%12.5) were positive for candiduria. Causative agents were identified as
Candida glabrata (n=19, 50%), C. albicans (n=12, 31.6%), C. krusei (n=4, 10.5%), C. tropicalis (n=2, 5.3%), and
C. kefyr (n=1, 2.6%). According to the results of the statistical analyses, there were significant association between
candiduria and female gender, high FBS and urine glucose, uncontrolled diabetes (HbA1c ≥8), and acidic urine pH (P<0.05).
Conclusion: Considering the high incidence rate of candiduria in diabetic patients, control of diabetes, predisposing factors, and causal relationships between diabetes and candiduria should be highlighted. |
topic |
Candida Diabetes HbA1c Urinary tract infections |
url |
http://cmm.mazums.ac.ir/browse.php?a_code=A-10-88-1&slc_lang=en&sid=1 |
work_keys_str_mv |
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