Targeting Hidden Pathogens: Cell-Penetrating Enzybiotics Eradicate Intracellular Drug-Resistant Staphylococcus aureus

Targeting Hidden Pathogens: Cell-Penetrating Enzybiotics Eradicate Intracellular Drug-Resistant Staphylococcus aureus

The increasing prevalence of antibiotic-resistant bacteria is one of the most urgent problems of our time. Staphylococcus aureus is an important human pathogen that has acquired several mechanisms to evade antibiotic treatment. In addition, S. aureus is able to invade and persist within human cells,...

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Bibliographic Details
Main Authors: Christian Röhrig, Markus Huemer, Dominique Lorgé, Samuel Luterbacher, Preeda Phothaworn, Christopher Schefer, Anna M. Sobieraj, Léa V. Zinsli, Srikanth Mairpady Shambat, Nadja Leimer, Anja P. Keller, Fritz Eichenseher, Yang Shen, Sunee Korbsrisate, Annelies S. Zinkernagel, Martin J. Loessner, Mathias Schmelcher
Format: Article
Language:English
Published: American Society for Microbiology 2020-04-01
Series:mBio
Subjects:
endolysin
mrsa
staphylococcus aureus
antibiotic resistance
bacteriophages
cell-penetrating peptide
intracellular bacteria
peptidoglycan hydrolases
persister
protein therapeutic
small-colony variant
Online Access:https://doi.org/10.1128/mBio.00209-20

Internet

https://doi.org/10.1128/mBio.00209-20

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