Concerted EP2 and EP4 Receptor Signaling Stimulates Autocrine Prostaglandin E<sub>2</sub> Activation in Human Podocytes

Concerted EP2 and EP4 Receptor Signaling Stimulates Autocrine Prostaglandin E<sub>2</sub> Activation in Human Podocytes

Glomerular hyperfiltration is an important mechanism in the development of albuminuria. During hyperfiltration, podocytes are exposed to increased fluid flow shear stress (FFSS) in Bowman’s space. Elevated Prostaglandin E2 (PGE<sub>2</sub>) synthesis and upregulated cyclooxygenase 2 (Cox...

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Bibliographic Details
Main Authors: Eva Mangelsen, Michael Rothe, Angela Schulz, Aikaterini Kourpa, Daniela Panáková, Reinhold Kreutz, Juliane Bolbrinker
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cells
Subjects:
podocyte
hyperfiltration
chronic kidney disease
prostaglandin E2
COX2
EP2
Online Access:https://www.mdpi.com/2073-4409/9/5/1256

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https://www.mdpi.com/2073-4409/9/5/1256

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