Growth factors and new periodontology

• Main Authors: Paknejad M, Ranjbar R
• Format: Article
• Language: fas
• Published: Tehran University of Medical Sciences 1999-06-01
• Series: Journal of Dental Medicine
• Subjects: Growth factors; Regeneration of periodontal defects; Osseo integration
• Online Access: http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/5384.pdf&manuscript_id=5384

Growth factors are biological mediators that have a key roll in proliferation, chemotaxy and"ndifferentiation by acting on specific receptors on the surface of cells and regulating events in wound"nhealing.They can be considered hormones that are not released in to the blood stream but have one a"nlocal action. Some of these factors can regulate premature change in GO to Gl phase in cell devesion"ncycle and even may stimulate synthesis of DNA in suitable cells, Growth substances, primarily secreted"nby fibroblasts, endothelia! cells, macrophages and platelet, include platelet derived growth factor"n(PDGF), insulin like growth factor (IGF) transforming growth factor (TGF)a and (3 and bone"nmorphogenetic proteins BMPs that approximately are the most important of them. (BMP)s could be"nused to control events during periodontal, craniofacial and implant wound healing through favoring bone"nformation"nAccording toLynch, combination of PGDF and IGF1 would be effective in promoting growth of all the"ncomponents of the periodontium."nThe aim of this study was to characterize growth factor and review the literature to determine the"nmechanism of their function, classification and application in implant and periodontal treatment.